Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

  • EC / List name:
  • IUPAC name: 1'-[3-(dimethylamino)propyl]-5'-(2-{3-[2-(4-{2-[3-(2-{1'-[3-(dimethylamino)propyl]-6'-hydroxy-4'-methyl-2'-oxo-1',2'-dihydro-1lambda5-[1,3'-bipyridin]-1-ylium-5'-yl}diazen-1-yl)phenyl]diazen-1-yl}-2,6-dihydroxyphenyl)diazen-1-yl]phenyl}diazen-1-yl)-6'-hydroxy-4'-methyl-2'-oxo-1',2'-dihydro-1lambda5-[1,3'-bipyridin]-1-ylium 1'-[3-(dimethylamino)propyl]-5'-(2-{4-[2-(4-{2-[4-(2-{1'-[3-(dimethylamino)propyl]-6'-hydroxy-4'-methyl-2'-oxo-1',2'-dihydro-1lambda5-[1,3'-bipyridin]-1-ylium-5'-yl}diazen-1-yl)phenyl]diazen-1-yl}-2,6-dihydroxyphenyl)diazen-1-yl]phenyl}diazen-1-yl)-6'-hydroxy-4'-methyl-2'-oxo-1',2'-dihydro-1lambda5-[1,3'-bipyridin]-1-ylium tetrahydrochloride tetrachloride
  • Substance names and other identifiers
EC / List no.:
404-540-1
CAS no.:
-
Index number:
Molecular formula:
C100H112Cl8N28O12
SMILES:
Cl.Cl.Cl.Cl.[Cl-].[Cl-].[Cl-].[Cl-].CN(C)CCCN1C(O)=C(N=NC2=CC=C(C=C2)N=NC2=CC(O)=C(N=NC3=CC=C(C=C3)N=NC3=C(O)N(CCCN(C)C)C(=O)C(=C3C)[N+]3=CC=CC=C3)C(O)=C2)C(C)=C(C1=O)[N+]1=CC=CC=C1.CN(C)CCCN1C(O)=C(N=NC2=CC=CC(=C2)N=NC2=CC(O)=C(N=NC3=CC(=CC=C3)N=NC3=C(O)N(CCCN(C)C)C(=O)C(=C3C)[N+]3=CC=CC=C3)C(O)=C2)C(C)=C(C1=O)[N+]1=CC=CC=C1
InChI:
InChI=1S/2C50H52N14O6.8ClH/c1-33-42(47(67)63(29-13-23-59(3)4)49(69)45(33)61-25-9-7-10-26-61)56-52-36-17-15-35(16-18-36)51-55-39-31-40(65)44(41(66)32-39)58-54-38-21-19-37(20-22-38)53-57-43-34(2)46(62-27-11-8-12-28-62)50(70)64(48(43)68)30-14-24-60(5)6;1-33-42(47(67)63(27-15-21-59(3)4)49(69)45(33)61-23-9-7-10-24-61)56-52-36-18-13-17-35(29-36)51-55-39-31-40(65)44(41(66)32-39)58-54-38-20-14-19-37(30-38)53-57-43-34(2)46(62-25-11-8-12-26-62)50(70)64(48(43)68)28-16-22-60(5)6;;;;;;;;/h7-12,15-22,25-28,31-32H,13-14,23-24,29-30H2,1-6H3,(H2-2,51,52,53,54,55,56,57,58,65,66,67,68,69,70);7-14,17-20,23-26,29-32H,15-16,21-22,27-28H2,1-6H3,(H2-2,52,53,54,65,66,67,68,69,70);8*1H
Type of substance:
Multi constituent substance
Origin:
Organic
Registered compositions:
3
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
ELINCS (European LIst of Notified Chemical Substances) List

Hazard classification & labelling

Warning! According to the harmonised classification and labelling (CLP00) approved by the European Union, this substance may cause an allergic skin reaction.

Breakdown of all 58 C&L notifications submitted to ECHA

Skin Sens. 1 H317 Harmonised Classification
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

  • Ss
Officially recognised in the EU as Skin sensitising ( Harmonised C&L).
  • Ss
There is no overall agreement among data submitters, but a minority indicate they consider this substance as Skin sensitising (33.33% of REACH registrations).

Regulatory activities

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 6 active registrations under REACH, 1 Joint Submission(s) and 1 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Registration dossiers submitted to ECHA for this substance have been evaluated under REACH.
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Notification:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is manufactured and/or imported in the European Economic Area in 100+ tonnes per year.

This substance is used in articles, in formulation or re-packing, at industrial sites and in manufacturing.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

This substance is used in the following activities or processes at workplace: the low energy manipulation of substances bound in materials or articles.

Release to the environment of this substance can occur from industrial use: industrial abrasion processing with low release rate (e.g. cutting of textile, cutting, machining or grinding of metal). Other release to the environment of this substance is likely to occur from: outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials) and indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment).

This substance can be found in products with material based on: paper (e.g. tissues, feminine hygiene products, nappies, books, magazines, wallpaper).

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

ECHA has no public registered data on the types of manufacture using this substance.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

This substance is used in the following activities or processes at workplace: closed batch processing in synthesis or formulation, mixing in open batch processes, transfer of chemicals at dedicated facilities and transfer of substance into small containers.

Release to the environment of this substance can occur from industrial use: formulation of mixtures.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

This substance is used for the manufacture of: wood and wood products and pulp, paper and paper products.

This substance is used in the following activities or processes at workplace: transfer of chemicals at dedicated facilities, mixing in open batch processes, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation and transfer of substance into small containers.

Release to the environment of this substance can occur from industrial use: in the production of articles.

This substance is used in the following activities or processes at workplace: closed batch processing in synthesis or formulation, mixing in open batch processes, transfer of chemicals at dedicated facilities and transfer of substance into small containers.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: contaminated work clothing should not be allowed out of the workplace; wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier.

Response statements

In case of incident: Wash contaminated clothing before reuse. If skin irritation or a rash occurs: get medical advice/attention. If on skin: wash with soap and water.

Disposal statements

The substance must be disposed in accordance with local/regional/national/international regulation.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • Archroma Germany GmbH, Kasteler Str. 45 65203 Wiesbaden Germany
  • ARCHROMA IBÉRICA, S.L., ZAL-Prat c/Cal Coracero, 46-56 08820 El Prat de Llobregat Spain
  • Archroma UK, Ltd, Bowling Old Lane BD5 7JL Bradford United Kingdom
  • Archroma Italy, S.r.l., Via Manzoni 37 20030 Palazzolo Milanese Italy

Substance names and other identifiers

A mixture of isomers of: 1,1'-[(3,5(or 2,4 or 4,6 or 2,6)-dihydroxy-o(or m or p)-phenylene)bis(azo-meta-phenyleneazo{1-[3-(dimethylamino)propyl]-1,2-dihydro-6-hydroxy-4-methyl-2-oxopyridine-5,3-diyl})]dipyridinium-dichloride-dihydrochloride; 1-(1-[3-(dimethylamino)propyl]-5-{3-[x-(4-{1-[3-(dimethylamino)propyl]-1,6-dihydro-2-hydroxy-4-methyl-6-oxo-5-pyridinio-3-pyridylazo}phenylazo)-2,4(or 2,6 or 3,5 or 4,6)-dihydroxyphenylazo]phenylazo}-1,2-dihydro-6-hydroxy-4-methyl-2-oxo-3-pyridyl)pyridinium-dichloride-dihydrochloride (where x is variable)
EC Inventory, REACH pre-registration
reaction mass of 1,1'-((dihydroxyphenylene)bis(azo-3,1-phenylenazo(1-(3-dimethylaminopropyl)-1,2-dihydro-6-hydroxy-4-methyl-2-oxopyridine-5,3-diyl)))dipyridinium dichloride dihydrochloride, mixed isomers and 1-(1-(3-dimethylaminopropyl)-5-(3-((4-(1-(3-dimethylaminopropyl)-1,6-dihydro-2-hydroxy-4-methyl-6-oxo-5-pyridinio-3-pyridylazo)phenylazo)-2,4(or2,6 or3,5)-dihydroxyphenylazo)phenylazo)-1,2-dihydro-6-hydroxy-4-methyl-2-oxo-3-pyridyl)pyridinium dichloride
C&L Inventory
1,1'-((dihidroksifenilēn)-bis-(azo-3,1-fenilēnazo(1-(3-(dimetilamino)propil)-1,2-dihidro-6-hidroksi-4-metil-2-oksopiridīn-5,3-diil)))dipiridīnija dihlorīda un dihidrohlorīda izomēru maisījuma un 1-(1-(3-dimetilaminopropil)-5-(3-((4-(1-(3-dimetilaminopropil)-1,6-dihidro-2-hidroksi-4-metil-6-okso-5-piridinio-3-piridilazo)fenilazo)-2,4 (vai 2,6 vai 3,5)-dihidroksifenilazo)fenilazo)-1,2-dihidro-6-hidroksi-4-metil-2-okso-3-piridil)piridīnija dihlorīda maisījums (lv)
C&L Inventory
1,1'-[(dihidroksifenilen)bis[azo-3,1-fenilenazo[1-[3-(dimetilamino)propil]-1,2-dihidro-6-hidroksi-4-metil-2-oksopiridin-5,3-diil]]]dipiridinio dichlorido ir rūgščiojo dichlorido mišinys ir 1-[1-(3-dimetilaminopropil)-5-[3-[[4-[1-(3-dimetilaminopropil)-1,6-dihidro-2-hidroksi-4-metil-6-okso-5-piridinio-3-piridilazo]fenilazo]-2,4(arba 2,6 arba 3,5)-dihidroksifenilazo]-fenilazo]-1,2-dihidro-6-hidroksi-4-metil-2-okso-3-piridil]piridinio dichlorido izomerų mišinys (lt)
C&L Inventory
1,1'-[(dihydroxifenylen)bis[azo-3,1-fenylenazo[1-[3-(dimetylamino)propyl]-1,2-dihydro-6-hydroxi-4-metyl-2-oxopyridin-5,3-diyl]]]dipyridiniumdiklorid, dihydroklorid, isomerblandning och 1-[1-(3-dimetylaminopropyl)-5-[3-[[4-[1-(3-dimetylaminopropyl)- (sv)
C&L Inventory
1,1`-((Dihydroksifenyleeni)bis(atso-3,1-fenyleeniatso(1-(3-dimetyyliaminopropyyli)-1,2-dihydro-6-hydroksi-4-metyyli-2-oksopyridiini-5,3-diyyli)))dipyridiinidiklorididihydrokloridi, isomeerien seos (fi)
C&L Inventory
1,1´- (m- dihydroxybenzendiylbis{azo- 1,3- fenylenazo[1- (3- dimethylaminopropyl) - 2- hydroxy- 4- methyl- 6(1H) - oxopyridin- 3,5- diyl]} ) di(pyridinium) - dichlorid- dihydrochlorid (reakční směs isomerů) (cs)
C&L Inventory
1,1’-[(dihidroxifenilén)bisz(azo-3,1-fenilénazo(1-(3-dimetilaminopropil)-1,2-dihidro-6-hidroxi-4-metil-2-oxopiridin-5,3-diil)))dipiridinium-diklorid-dihidroklorid izomerkeverék és 1-(1-(3-dimetilaminopropil)-5-(3-((4-(1-(3-dimetilaminopropil)-1,6-dihidro-2-hidroxi-4-metil-6-oxo-5-piridinio-3-piridilazo)fenilazo)-2,4(vagy 2,6 vagy3,5)-dihidroxifenilazo)fenilazo)-1,2-dihidro-6-hidroxi-4-metil-2-oxo-3-piridil)piridinium-diklorid keveréke (hu)
C&L Inventory
Blanding af 1-(1-(3-dimethylaminopropyl)-5-(3-((4-(1-(3-dimethylaminopropyl)-1,6-dihydro-2-hydroxy-4-methyl-6-oxo-5-pyridinio-3-pyridylazo)phenylazo)-2,4(eller2,6 eller3,5)-dihydroxyphenylazo)phenylazo)-1,2-dihydro-6-hydroxy-4-methyl-2-oxo-3-pyridyl)pyridiniumdichlo og 1,1'-((dihydroxyphenylen)bis(azo-3,1-phenylenazo(1-(3-(dimethylamino)propyl)-1,2-dihydro-6-hydroxy-4-methyl-2-oxopyridin-5,3-diyl)))dipyridiniumdichlorid, dihydrochlorid, blanding af isomerer (da)
C&L Inventory
blanding av: 1,1'-((dihydroksyfenylen)bis(azo-3,1-fenylenazo(1-(3-dimetylaminopropyl)-1,2-dihydro-6-hydroksy-4-metyl-2-oksopyridin-5,3-diyl)))dipyridiniumdikloriddihydroklorid, isomerblanding og 1-(1-(3-dimetylaminopropyl)-5-(3-((4-(1-(3-dimetylaminopropyl)-1,6-dihydro-2-hydroksy-4-metyl-6-okso-5-pyridino-3-pyridylazo)fenylazo)-2,4(eller 2,6 eller 3,5)-dihydroksyfenylazo)fenylazo)-1,2-dihydro-6-hydroksy-4-metyl-2-okso-3-pyridyl)pyridiniumdikloriddihydroklorid, isomerblanding (no)
C&L Inventory
masa de reactie a 1,1'-((dihidroxifenilen)bis(azo-3,1-fenilenazo(1-(3-dimetilaminopropil)-1,2-dihidro-6-hidroxi-4-metil-2-oxopiridine-5,3-diil)))dipiridiniu diclorura dihidroclorate, amestec de izomeri si 1-(1-(3-dimetilaminopropil)-5-(3-((4-(1-(3-dimetilaminopropil)-1,6-dihidro-2-hidroxi-4-metil-6-oxo-5-piridinio-3-piridilazo)fenilazo)-2,4(sau 2,6 sau 3,5)-dihidroxifenilazo)fenilazo)-1,2-dihidro-6-hidroxi-4-metil-2-oxo-3-piridil)piridiniu diclorura (ro)
C&L Inventory
Mengsel van 1,1'-((dihydroxyfenyleen)bis(azo-3,1-fenilenazo(1-(3-(dimethylamino)propyl)-1,2-dihydro-6-hydroxy-4-methyl-2-oxopyridine-5,3-diyl)))dipyridiniumdichloride, dihydrochloride, mengsel van isomeren en 1-(1-(3-dimethylaminopropyl)-5-(3-((4-(1-(3-dimethylaminopropyl)-1,6-dihydro-2-hydroxy-4-methyl-6-oxo-5-pyridinio-3-pyridylazo)fenylazo)-2,4(of2,6 of3,5)-dihydroxyfenylazo)fenylazo)-1,2-dihydro-6-hydroxy-4-methyl-2-oxo-3-pyridyl)pyridiniumdichloridedihyd (nl)
C&L Inventory
Mezcla de dicloruro de 1,1'-((dihidroxifenilen)bis(azo-3,1-fenilenazo(1-(3-(dimetilamino)propil)-1,2-dihidro-6-hidroxi-4-metil-2-oxopiridina-5,3-diil)))dipiridinio, diclorhidrato, mezcla de isomeros y dicloruro de 1-(1-(3-dimetilaminopropil)-5-(3-((4-(1-(3-dimetilaminopropil)-1,6-dihidro-2-hidroxi-4-metil-6-oxo-5-piridinio-3-piridilazo)fenilazo)-2,4(o2,6 o3,5)-dihidroxifenilazo)fenilazo)-1,2-dihidro-6-hidroxi-4-metil-2-oxo-3-piridil)piridinio, diclor (es)
C&L Inventory
mieszanina: dichlorku dichlorowodorku 1,1'-[(dihydroksyfenyleno)bis{azo-3,1-fenylenoazo[1-(3-dimetyloamino-propylo)-6-hydroksy-4-metylo-2-okso--1,2-dihydropirydyn-5,3-diylo]}dipirydynium (mieszanina izomerów) i dichlorku 1-[1-(3-dimetyloaminopropylo)-5-(3-{[4-(1-{3-dimetyloaminopropylo}-2-hydroksy-4-metylo-6-okso-5-pirydynio-1,6-dihydro-3-pirydyloazo)-fenyloazo]-2,4(lub 2,6 lub 3,5)-dihydroksyfenyloazo}fenyloazo)-6-hydroksy-4-metylo-2-okso-1,2-dihydro-3-pirydylo]-pirydynium (pl)
C&L Inventory
Miscela di dicloruro di 1,1'-((dihidroxifenilen)bis(azo-3,1-fenilenazo(1-(3-(dimetilammino)propil)-1,2-diidro-6-idrossi-4-metil-2-ossopiridin-5,3-diil)))dipiridinio, dicloridrato, miscela di isomeri e dicloruro di 1-(1-(3-dimetilamminopropil)-5-(3-((4-(1-(3-dimetilamminopropil)-1,6-diidro-2-idrossi-4-metil-6-osso-5-piridinio-3-piridilazo)fenilazo)-2,4(o2,6 o3,5)-diidrossifenilazo)fenilazo)-1,2-diidro-6-idrossi-4-metil-2-osso-3-piridil)piridinio, diclo (it)
C&L Inventory
Mistura de dicloreto de 1-(1-(3-dimetilaminopropil)-5-(3-((4-(1-(3-dimetilaminopropil)-1,6-dihidro-2-hidroxi-4-metil-6-oxo-5-piridinio-3-piridilazo)fenilazo)-2,4(ou2,6 ou3,5)-dihidroxifenilazo)fenilazo)-1,2-dihidro-6-hidroxi-4-metil-2-oxo-3-piridil)piridinio, diclo e dicloreto de 1,1'-((dihidroxifenileno)bis(azo-3,1-fenilenazo(1-(3-(dimetilamino)propil)-1,2-dihidro-6-hidroxi-4-metil-2-oxopiridina-5,3-diil)))dipiridinio, dicloridrato, mistura de isomeros (pt)
C&L Inventory
Mélange de dichlorure de 1-(1-(3-diméthylaminopropyl)-5-(3-((4-(1-(3-diméthylaminopropyl)-1,6-dihydro-2-hydroxy-4-méthyl-6-oxo-5-pyridinio-3-pyridylazo)phénylazo)-2,4(ou2,6 ou3,5)-dihydroxyphénylazo)phénylazo)-1,2-dihydro-6-hydroxy-4-méthyl-2-oxo-3-pyridyl)pyridini et dichlorure de 1,1'-((dihydroxyphénylne)bis(azo-3,1-phénylnazo(1-(3-(diméthylamino)propyl)-1,2-dihydro-6-hydroxy-4-méthyl-2-oxopyridine-5,3-diyl)))dipyridinium, dichlorhydrate, mélange d'isomères (fr)
C&L Inventory
Reaction mass aus 1,1'-((Dihydroxyphenylen)bis(azo-3,1-phenylenazo(1-(3-(dimethylamino)propyl)-1,2-dihydro-6-hydroxy-4-methyl-2-oxopyridin-5,3-diyl)))dipyridiniumdichlorid, dihydrochlorid, Reaction mass aus Isomeren und 1-(1-(3-Dimethylaminopropyl)-5-(3-((4-(1-(3-dimethylaminopropyl)-1,6-dihydro-2-hydroxy-4-methyl-6-oxo-5-pyridinio-3-pyridylazo)phenylazo)-2,4(oder2,6 oder3,5)-dihydroxyphenylazo)phenylazo)-1,2-dihydro-6-hydroxy-4-methyl-2-oxo-3-pyridyl)pyridiniumdiclorid (de)
C&L Inventory
reakcijska smjesa 1,1'-((dihidroksifenilen)bis(azo-3,1-fenilenazo(1-(3-dimetilaminopropil)-1,2-dihidro-6-hidroksi-4-metil-2-oksopiridin-5,3-diil)))dipiridinij diklorid dihidroklorida, smjese izomera i 1-(1-(3-dimetilaminopropil)-5-(3-((4-(1-(3-dimetilaminopropil)-1,6-dihidro-2-hidroksi-4-metil-6-okso-5-piridinio-3-piridilazo)fenilazo)-2,4(ili 2,6 ili 3,5)-dihidroksifenilazo)fenilazo)-1,2-dihidro-6-hidroksi-4-metil-2-okso-3-piridil)piridinij diklorida (hr)
C&L Inventory
reakčná zmes zložená zo zmesi izomérov 1,1'-[(dihydroxyfenylén)bis(diazéndiyl-3,1-fenyléndiazéndiyl{1-[3-(dimetylamónio)propyl]-6-hydroxy-4-metyl-2-oxo-1,2-dihydropyridín-5,3-diyl})]dipyridínium-tetrachloridu a 1-{1-[3-(dimetylamónio)propyl]-5-[3-(4-{1-[3-(dimetylamónio)propyl]-2-hydroxy-4-metyl-6-oxo-5-pyridínio-1,6-dihydro-3-pyridyldiazenyl]fenyldiazenyl}-2,4(alebo 2,6 alebo 3,5)-dihydroxyfenyldiazenyl)fenyldiazenyl]-6-hydroxy-4-metyl-2-oxo-1,2-dihydro-3-pyridyl}pyridínium-tetrachloridu (sk)
C&L Inventory
Segu: 1,1'-((Dihüdroksüfenüleen)bis(aso-3,1-fenüleen-aso(1-(3- dimetüülaminopropüül)-1,2-dihüdro-6-hüdroksü-4- metüül-2-oksopüridiin-5,3-diüül)))di-püridiindikloriiddihüdrokloriid, isomeeride segu ja 1-(1-(3-dimetülaminopropüül)-5-(3-((4-(1-(3-dimetüülaminopropüül)-1,6-dihüdro-2-hüdroksü-4-metüül-6-okso-5-püridiin-3-püridüülaso)fenüülaso)-2,4( või 2,6 või 3,5)-dihüdroksüfenüülaso)fenüülaso)-1,2-dihüdro-6-hüdroksü-4-metüül-2-okso-3-püridüül)püridiindikloriid (et)
C&L Inventory
zmes 1,1'-((dihidroksifenilen)bis{azo-3,1-fenilazo[1-(3-dimetilaminopropil)-1,2-dihidro-6-hidroksi-4-metil-2-oksopiridin-5,3-diil]})dipiridinijevega diklorida dihidroklorida in 1-[1-(3-dimetilaminopropil)-1,6-dihidro-2-hidroksi-4-metil-6-okso-5-piridino-3-piridilazo]fenilazo)-2,4(ali 2,6 ali 3,5)dihidroksifenilazo)fenilazo)-1,2-dihidro-6-hidroksi-4-metil-2-okso-3-piridil)piridinijevega diklorida (sl)
C&L Inventory
διχλωρίδιo τoυ 1,1'-((διυδρoξυφαινυλενo)δις(αζω-3,1-φαινυλεναζω(1-(3-(διμεθυλαμινo)πρoπυλo)-1,2-διυδρo-6-υδρoξυ-4-μεθυλo-2-oξoπυριδινo-5,3-διυλo)))διπυριδινίoυ, διυδρoχλωρικBo, μείγμα ισoμερών διχλωρ΄ιδιο του 1-(1-(3-διμεθυλαμινοπροπυλο)-5-(3-((4-(1-(3-διμεθυλαμινοπροπυλο)-1,6-διυδρο-2-υδροξυ-4-μεθυλ-6-οξο-5-πυριδινιο-3-πυριδυλαζω)φαινυλαζω)-2,4(η2,6 η3,5)-διυδροξυφαινυλαζω)φαινυλαζω)-1,2-διυδρο-6-υδροξυ-4-μεθυλ-2-οξο-3-πυριδυλο)πυριδιν΄ιου διυδροχλωρικ΄ (el)
C&L Inventory
реакционна маса от 1,1'-((дихидроксифенилен)бис(aзо-3,1-фениленазо(1-(3-(диметиламинопропил)-1,2-дихидро-6-хидрокси-4-метил-2-oксопиридин-5,3-диил)))дипиридин дихлорид дихидрохлорид, изомерна смес и 1-(1-(3-диметиламинопропил)-5-(3-((4-(1-(3-диметиламинопропил)-1,6-дихидро-2-хидрокси-4-метил-6-оксо-5-пиридино-3-пиридилазо)фенилазо)-2,4(или2,6 или 3,5)-дихидроксифенилазо)фенилазо)-1,2-дихидро-6-хидрокси-4-метил-2-оксо-3-пиридил)пиридин дихлорид (bg)
C&L Inventory
1,3'-Bipyridinium, 5',5'''-[(dihydroxyphenylene)bis(azo-3,1-phenyleneazo)]bis[1'-[3-(dimethylamino)propyl]-1',2'-dihydro-6'-hydroxy-4'-methyl-2'-oxo-, dichloride, dihydrochloride
Other
1'-[3-(dimethylamino)propyl]-5'-(2-{3-[2-(4-{2-[3-(2-{1'-[3-(dimethylamino)propyl]-6'-hydroxy-4'-methyl-2'-oxo-1',2'-dihydro-1lambda5-[1,3'-bipyridin]-1-ylium-5'-yl}diazen-1-yl)phenyl]diazen-1-yl}-2,6-dihydroxyphenyl)diazen-1-yl]phenyl}diazen-1-yl)-6'-hydroxy-4'-methyl-2'-oxo-1',2'-dihydro-1lambda5-[1,3'-bipyridin]-1-ylium 1'-[3-(dimethylamino)propyl]-5'-(2-{4-[2-(4-{2-[4-(2-{1'-[3-(dimethylamino)propyl]-6'-hydroxy-4'-methyl-2'-oxo-1',2'-dihydro-1lambda5-[1,3'-bipyridin]-1-ylium-5'-yl}diazen-1-yl)phenyl]diazen-1-yl}-2,6-dihydroxyphenyl)diazen-1-yl]phenyl}diazen-1-yl)-6'-hydroxy-4'-methyl-2'-oxo-1',2'-dihydro-1lambda5-[1,3'-bipyridin]-1-ylium tetrahydrochloride tetrachloride
Other
BROWN HM 2763
Registration dossier
Not applicable
Registration dossier
159405-95-5
CAS number
Other
611-016-00-8
Index number
C&L Inventory

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 1 study submitted
  • 1 study processed
C Physical state at 20°C and 1013 hPa
Solid (100%) [1]
C Form
Powder (100%) [1]
C Odour
Other (100%) [1]
C Substance type
Organic (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Physical state at 20°C and 1013 hPa
Liquid (100%)

Melting/freezing point

Study results
  • 1 study submitted
  • 1 study processed
R Melting / freezing point
299.85 - 300 °C @ 101.325 kPa [2]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Melting / freezing point at 101 325 Pa
300 °C

Boiling point

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Density

Study results
  • 1 study submitted
  • 1 study processed
R Relative density
1.11 @ 20 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Relative density at 20°C
1.112

Vapour pressure

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
R Summaries
  • 1 summary submitted
  • 1 summary processed
Vapour pressure
0 Pa @ 20 °C

Partition coefficient

Study results
  • 1 study submitted
  • 1 study processed
R Pow
1 @ 28 °C and pH 0 - 14 [1]
R Log Pow
0 @ 28 °C and pH 0 - 14 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Log Kow (Log Pow)
-1 @ 20 °C

Water solubility

Study results
  • 1 study submitted
  • 1 study processed
R Water solubility (mass/vol.)
500 g/L @ 20 °C and pH 4.8 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Water solubility
1 000 g/L @ 20 °C

Solubility in organic solvents / fat solubility

Study results
  • 1 study submitted
  • 1 study processed
R Standard fat
1.4 mg/L @ 37 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Surface tension

Study results
  • 1 study submitted
  • 1 study processed
R Surface tension
73.2 mN/m @ 528 mg/L and 22 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Surface tension at 20 °C
73.2 mN/m @ 528 mg/L

Flash point

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Auto flammability

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Flammability

Study results
  • 1 study submitted
  • 1 study processed
C Interpretation of results
Non flammable (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Flammability
Non flammable (100%)

Explosiveness

Study results
  • 1 study submitted
  • 1 study processed
C Interpretation of results
Non-explosive (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Oxidising
No (100%)

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Viscosity

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Data not provided by the registrant

Hydrolysis

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in water

Data not provided by the registrant

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 2 studies submitted
  • 2 studies processed
C Interpretation of results
Not inherently biodegradable (50%), Under test conditions no biodegradation observed (50%) [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Biodegradation in water
Under test conditions no biodegradation observed (100%)

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in soil

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: aquatic / sediment

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Henrys law constant (H)

Data not provided by the registrant

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 1 summary submitted
  • 1 summary processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater No hazard identified (1)
Intermittent releases (freshwater) No hazard identified (1)
Marine water No hazard identified (1)
Intermittent releases (marine water) No hazard identified (1)
Sewage treatment plant (STP) No hazard identified (1)
Sediment (freshwater) No hazard identified (1)
Sediment (marine water) No hazard identified (1)
Hazard for Air
Air No hazard identified (1)
Hazard for Terrestrial Organism
Soil No hazard identified (1)
Hazard for Predators
Secondary poisoning Insufficient hazard data available (further information necessary) (1)

Short–term toxicity to fish

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
LC50 (4 days) 115 - 143 mg/L [2]
LC0 (4 days) 44.8 - 56 mg/L [2]
LC100 (4 days) 256 - 320 mg/L [2]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
LC50 for freshwater fish
115 mg/L

Long–term toxicity to fish

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Short–term toxicity to aquatic invertebrates

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
EC50 (48 h) 156.8 mg/L [1]
EC100 (48 h) 320 mg/L [1]
NOEC (48 h) 32 mg/L [2]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 / LC50 for freshwater invertebrates
156.8 mg/L

Long–term toxicity to aquatic invertebrates

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to aquatic algae and cyanobacteria

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to aquatic plants other than algae

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
EC50 (7 days) 4.8 - 105 mg/L [5]
NOEC (7 days) 35 - 105 000 µg/L [5]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to microorganisms

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
IC50 (3 h) 100 mg/L [1]
NOEC (3 h) 100 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Sediment toxicity

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
LC50 (14 days) 1 g/kg soil dw [1]
LC0 (14 days) 1 g/kg soil dw [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial arthropods

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial plants

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to soil microorganisms

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to birds

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 1 summary submitted
  • 1 summary processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 11.75 mg/m³ repeated dose toxicity
Acute /short term: (DNEL) 58.75 mg/m³ repeated dose toxicity
Local Effects
Long-term: Medium hazard (no threshold derived)
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 3.33 mg/kg bw/day repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: High hazard (no threshold derived)
Acute /short term: No hazard identified
EYE Exposure
No hazard identified
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 2.9 mg/m³ repeated dose toxicity
Acute /short term: (DNEL) 14.5 mg/m³ repeated dose toxicity
Local Effects
Long-term: Medium hazard (no threshold derived)
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 1.67 mg/kg bw/day repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: High hazard (no threshold derived)
Acute /short term: No hazard identified
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 1.67 mg/kg bw/day repeated dose toxicity
Acute /short term: (DNEL) 5 mg/kg bw/day repeated dose toxicity
EYE Exposure
No hazard identified

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal absorption
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Bioaccumulation potential:
Low bioaccumulation potential

Acute toxicity

Study results
oral
  • 1 study submitted
  • 1 study processed
P/RResults
LD50 5 000 mg/kg bw (rat) [1]
M/CInterpretations of results
Study cannot be used for classification [1]

Type of Study provided
oral
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
inhalation
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

inhalation
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
dermal
  • 1 study submitted
  • 1 study processed
P/RResults
LD50 2 000 mg/kg bw (rat) [1]
M/CInterpretations of results
Study cannot be used for classification [1]

dermal
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Irritation / corrosion

Study results
Study data: skin
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: eye
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin
No adverse effect observed (not irritating)
Eye
No adverse effect observed (not irritating)
Respiratory
No study available

Sensitisation

Study results
Study data: skin
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin sensitisation
Adverse effect observed (sensitising)

Repeated dose toxicity

Study results
Study data: oral
  • 2 studies submitted
  • 1 study processed
P/RResults
NOAEL (rat): 1 000 mg/kg bw/day [1]
NOEL (rat): 200 mg/kg bw/day [1]

Type of Study provided
Study data: oral
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Study data: inhalation
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Study data: inhalation
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: dermal
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route - systemic effects:
No adverse effect observed NOAEL 1 000 mg/kg bw/day (subacute, rat)

Genetic toxicity

Study results
Study data: in vitro
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Study data: in vivo
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Carcinogenicity

Data not provided by the registrant

Toxicity to reproduction

Study results
Study data: reproduction
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Study data: developmental
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Effect on developmental toxicity
Oral route:
No adverse effect observed NOAEL 1 000 mg/kg bw/day (subacute, rat)

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant