Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
232-104-9
CAS no.:
7786-81-4
Index number:
Molecular formula:
NiO4S
SMILES:
[Ni++].[O-]S([O-])(=O)=O
InChI:
InChI=1S/Ni.H2O4S/c;1-5(2,3)4/h;(H2,1,2,3,4)/q+2;/p-2
Type of substance:
Mono constituent substance
Origin:
Inorganic
Registered compositions:
39
Of which contain:
29 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Danger! According to the harmonised classification and labelling (ATP01corr) approved by the European Union, this substance may cause cancer by inhalation, may damage the unborn child, causes damage to organs through prolonged or repeated exposure, is very toxic to aquatic life, is very toxic to aquatic life with long lasting effects, is harmful if swallowed, is harmful if inhaled, is suspected of causing genetic defects, causes skin irritation, may cause an allergic skin reaction and may cause allergy or asthma symptoms or breathing difficulties if inhaled.

Additionally, the classification provided by companies to ECHA in REACH registrations identifies that this substance may cause cancer, may damage fertility or the unborn child and causes serious eye irritation.

Breakdown of all 2454 C&L notifications submitted to ECHA

Acute Tox. 4 H302 Harmonised Classification
Skin Sens. 1 H317 Harmonised Classification
Resp. Sens. 1 H334 Harmonised Classification
Aquatic Acute 1 H400 Harmonised Classification
Repr. 1B H360D Harmonised Classification
STOT RE 1 H372 Harmonised Classification
Aquatic Chronic 1 H410 Harmonised Classification
Skin Irrit. 2 H315 Harmonised Classification
Acute Tox. 4 H332 Harmonised Classification
Muta. 2 H341 Harmonised Classification
Carc. 1B H350
Carc. 1A H350i Harmonised Classification
Eye Irrit. 2 H319
Carc. 2 H351
Muta. 2 H340
https://echa.europa.eu/diss-blank-theme/images/cnl/graph/more.png 0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

At least one notifier has indicated that an impurity or an additive present in the substance impacts the notified classification.

Properties of concern

  • C
Officially recognised in the EU as Carcinogenic (Harmonised C&L).
  • C
There is broad agreement in that a majority of data submitters agree this substance is Carcinogenic (100% of REACH registrations).
  • M
Suspected to be Mutagenic (Harmonised C&L).
  • R
Officially recognised in the EU as Toxic to Reproduction (Harmonised C&L).
  • R
There is broad agreement in that a majority of data submitters agree this substance is Toxic to Reproduction (100% of REACH registrations).
  • Ss
Officially recognised in the EU as Skin sensitising ( Harmonised C&L).
  • Ss
There is broad agreement in that a majority of data submitters agree this substance is Skin sensitising (100% of REACH registrations).
  • Sr
Officially recognised in the EU as Respiratory sensitising ( Harmonised C&L).
  • Sr
There is broad agreement in that a majority of data submitters agree this substance is Respiratory sensitising (100% of REACH registrations).

Regulatory activities

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 25 active registrations under REACH, 2 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Notification:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is manufactured and/or imported in the European Economic Area in 10 000 - 100 000 tonnes per year.

This substance is used in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

This substance is used in the following activities or processes at workplace: production of mixtures or articles by tabletting, compression, extrusion or pelletisation, potentially closed industrial processing with minerals/metals at elevated temperature (e.g. smelters, furnaces, refineries, coke ovens) and high energy work-up of substances bound in materials or articles (e.g. hot rolling/forming, grinding, mechanical cutting, drilling or sanding).

Release to the environment of this substance can occur from industrial use: as an intermediate step in further manufacturing of another substance (use of intermediates), manufacturing of the substance, formulation of mixtures and in the production of articles.

This substance can be found in complex articles, with no release intended: electrical batteries and accumulators.

This substance is used in the following products: metal surface treatment products and fertilisers.

This substance is used in the following areas: agriculture, forestry and fishing. This substance is used for the manufacture of: electrical, electronic and optical equipment and machinery and vehicles.

This substance is used in the following activities or processes at workplace: transfer of chemicals, the low energy manipulation of substances bound in materials or articles, closed, continuous processes with occasional controlled exposure, treatment of articles by dipping and pouring, batch processing in synthesis or formulation with opportunity for exposure, mixing in open batch processes, transfer of substance into small containers and roller or brushing applications.

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners).

This substance is used in the following products: metal surface treatment products and fertilisers.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed batch processing in synthesis or formulation, transfer of substance into small containers, manual maintenance (cleaning and repair) of machinery, batch processing in synthesis or formulation with opportunity for exposure, mixing in open batch processes, handling of solid inorganic substances (e.g. ores and raw metal oxides, packaging/mixing/blending and weighing of metal powders), closed processes with no likelihood of exposure and laboratory work.

Release to the environment of this substance can occur from industrial use: formulation of mixtures.

This substance is used in the following products: metal surface treatment products. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following areas: agriculture, forestry and fishing. This substance is used for the manufacture of: machinery and vehicles, chemicals, electrical, electronic and optical equipment and fabricated metal products.

This substance is used in the following activities or processes at workplace: manual maintenance (cleaning and repair) of machinery, transfer of chemicals, handling of solid inorganic substances (e.g. ores and raw metal oxides, packaging/mixing/blending and weighing of metal powders), transfer of substance into small containers, batch processing in synthesis or formulation with opportunity for exposure and closed, continuous processes with occasional controlled exposure.

Release to the environment of this substance can occur from industrial use: in the production of articles and as an intermediate step in further manufacturing of another substance (use of intermediates).

This substance is used in the following activities or processes at workplace: closed, continuous processes with occasional controlled exposure, transfer of chemicals, transfer of substance into small containers, batch processing in synthesis or formulation with opportunity for exposure, handling of solid inorganic substances (e.g. ores and raw metal oxides, packaging/mixing/blending and weighing of metal powders), potentially closed industrial processing with minerals/metals at elevated temperature (e.g. smelters, furnaces, refineries, coke ovens) and closed processes with no likelihood of exposure.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance.

ECHA has no data from registration dossiers on the precautionary measures for using this substance. Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • A.M.P.E.R.E. Deutschland GmbH, Emil-von-Behring Strasse 7-9 63128 DIETZENBACH Germany
  • A.M.P.E.R.E. INDUSTRIE, 5-7 Rue de Bretagne P.A. des Béthunes 95310 SAINT-OUEN-L'AUMONE VAL D'OISE France
  • Aurubis AG, Hovestrasse 50 20539 Hamburg Hamburg Germany
  • Aurubis Bulgaria, Industrial Zone 2070 Pirdop Bulgaria
  • Bochemie a.s., Lidicka 326 735 81 Bohumin Czech Republic
  • Boliden Harjavalta Oy, Teollisuuskatu 1 29200 Harjavalta Finland
  • Boliden Mineral AB, Rönnskärsverken 93281 Skelleftehamn Sweden
  • Brokermet SL, San Bernardo 82 28015 Madrid Spain
  • CENTRUM METAL ODCZYNNIKI CHEMICZNE - MIDAS INVESTMENT SPÓŁKA Z OGRANICZONĄ ODPOWIEDZIALNOŚCIĄ SP.K., ul. Opackiego 46A/11 05-090 Falenty Warszawa Poland
  • Glencore Nikkelverk AS, Vesterveien 31 4606 Kristiansand Norway
  • Hainan, S.L., Pol. Ind. “La Timba”, Ctra. N-260, Km. 41,2 17742 Avinyonet de Puigventós Figueres, Catalunya Spain
  • HALMA Handels GmbH, Reichstratsstrasse 11/3 1010 Wien Austria
  • ITALCHIMICI S.p.a., Via M. D'Azeglio, 62 25065 Lumezzane S.A. Brescia Italy
  • KGHM Polska Miedz S.A., ul. M. Skłodowskiej-Curie 48 59-301 Lubin Poland
  • Königswarter & Ebell, Chemische Fabrik GmbH, Im Ennepetal 19-21 58135 Hagen Germany
  • Montanwerke Brixlegg AG, Werkstraße 1 6230 Brixlegg Tirol Austria
  • Nickelhütte Aue GmbH, Rudolf-Breitscheid-Straße 65-75 D-08280 Aue Germany
  • Norilsk Nickel Harjavalta Oy, Teollisuuskatu 1 FI-29200 Harjavalta Finland
  • SAFT AB, Jungnergatan - Box 709 572 28 OSKARSHAMN Sweden
  • Specialty Metals Resources SA, Rue Tenbosch 42 A B 1050 Brussels Belgium
  • TODINI AND CO. SPA, Corso Milano 46 B 20900 MONZA ITALIA Italy
  • Umicore Finland Oy, Kobolttiaukio 1 67900 KOKKOLA Finland
  • UMICORE Galvanotechnik GmbH, 53-79 Klarenbergstrasse 73525 Schwäbisch Gmünd Germany
  • Umicore NV/SA, Rue du Marais 31 1000 Brussels Belgium
  • Vale Europe Limited, Acton Refinery Bashley Road NW10 6SN London GB United Kingdom
  • Arcerion GmbH, Gabrielenstr. 15 80636 Muenchen Germany
  • Siegfried Jacob Metallwerke GMBH & CO KG, Jacobstrasse 41- 45 58256 Ennepetal Germany

Substance names and other identifiers

Nickel sulfate
C&L Inventory, Other, EU. Worker Protection-Hazardous (98/24), EU. Dangerous Substances - Eco-Labels, EU. Pregnant Women Protection (92/85), EU. Workplace Signs, EU. Hazardous Waste Properties: Annex III (2008/98/EC), EU. Carcinogens/Mutagens Directive (2004/37), EU. Young People at Work (94/33)
Nickel sulfate (NiSO4)
Other
Nickel sulfate (VAN)
Other
Nickel sulfate(1:1)
Other
Nickel sulphate
EC Inventory, REACH pre-registration, Other, EU. Cosmetics Regulation, Annex II, Prohibited Substances
Nickel(2+) sulfate
Other
Nickel(2+) sulfate (1:1)
Other
Nickel(II) sulfate
Other
Nickel(II) sulfate (1:1)
Other
Nickelous sulfate
Other
Sulfuric acid nickel(2+) salt
Other
Sulfuric acid, nickel(2+) salt (1:1)
Other
Sulphuric acid, nickel(II) salt
Other
Nickelsulfat (de)
C&L Inventory
nikelio sulfatas (lt)
C&L Inventory
nikkel-szulfát (hu)
C&L Inventory
Nikkelisulfaatti (fi)
C&L Inventory
nikkelsulfaat (et)
C&L Inventory
nikkelsulfat (da)
C&L Inventory
nikljev sulfat (sl)
C&L Inventory
niklov sulfat (hr)
C&L Inventory
niķeļa sulfāts (lv)
C&L Inventory
siarczan (VI) niklu (II);siarczan niklawy (pl)
C&L Inventory
solfato di nichel (it)
C&L Inventory
sulfat de nichel (mt)
C&L Inventory
sulfate de nickel (fr)
C&L Inventory
sulfato de níquel (es)
C&L Inventory
síran nikelnatý (cs)
C&L Inventory
θειϊκό νικέλιο (el)
C&L Inventory
никелов сулфат (bg)
C&L Inventory
GFU NIckel sulphate C_L
C&L Inventory
Nickel (2+) Sulfate
C&L Inventory
Nickel (ii) sulphate
C&L Inventory
Nickel Sulphate (slime)
Registration dossier
Nickel sulphate hexahydrate
C&L Inventory
nickel(2+) ion sulfate
Registration dossier
nickel(2+);sulfate
Registration dossier
Nickel(II) sulfate heptahydrate
C&L Inventory
nickel(II) sulphate
C&L Inventory
Coarse discharge
Registration dossier
Conc. 1
Registration dossier
DER
Registration dossier
Intermediate nickel containing product
Registration dossier
nickel sulfate solution
Registration dossier
Nickel sulphate EN
Registration dossier
Nickel sulphate heptahydrate
Registration dossier
Nickel sulphate solution
Registration dossier
Nickel sulphate Std
Registration dossier
Reaction mass containing nickel sulphate
Registration dossier
Reduced sinter
Registration dossier
Roh-Nickelsulfat HK (Nickel sulphate, crude, HK)
Registration dossier
Rohnickelsulfat (Nickel sulphate, crude)
Registration dossier
SULFATE NICKEL EG
Registration dossier
SULFATE NICKEL ELECTROMONDE
Registration dossier
SULFATE NICKEL PG
Registration dossier
028-009-00-5
Index number
C&L Inventory
10101-97-0
CAS number
C&L Inventory
10101-98-1
CAS number
C&L Inventory
139939-67-6
CAS number
Other
1820866-61-2
CAS number
Other
7786-81-4
CAS number
EC Inventory, C&L Inventory, Registration dossier, REACH pre-registration, Other, EU. Worker Protection-Hazardous (98/24), EU. Cosmetics Regulation, Annex II, Prohibited Substances, EU. Dangerous Substances - Eco-Labels, EU. Pregnant Women Protection (92/85), EU. Workplace Signs, EU. Hazardous Waste Properties: Annex III (2008/98/EC), EU. Carcinogens/Mutagens Directive (2004/37), EU. Young People at Work (94/33)

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 1 study submitted
  • 1 study processed
C Physical state at 20°C and 1013 hPa
Solid (100%) [1]
C Form
Crystalline (100%) [1]
C Odour
Other (100%) [1]
C Substance type
Inorganic (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Melting/freezing point

Study results
  • 1 study submitted
  • 1 study processed
R Melting / freezing point
53 - 840 °C [3]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Boiling point

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Density

Study results
  • 1 study submitted
  • 1 study processed
R Density
1.95 - 3.68 g/cm³ @ 20 °C [3]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Vapour pressure

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Partition coefficient

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Water solubility

Study results
  • 1 study submitted
  • 1 study processed
R Water solubility (mass/vol.)
625 g/L @ 0 °C and pH 6 - 8 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Flash point

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Auto flammability

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Flammability

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Flammability
Non flammable (100%)

Explosiveness

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Oxidising

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Viscosity

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Hydrolysis

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in water

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in soil

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in water - screening tests

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in soil

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: aquatic / sediment

Study results
  • 135 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 45 1
Supporting study 52
Weight of evidence
Other 28 9
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: terrestrial

Study results
  • 54 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 11
Supporting study 26 1 3
Weight of evidence
Other 13
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Adsorption/desorption

Study results
  • 40 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 19 7 1
Supporting study 3
Weight of evidence
Other 10
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Henrys law constant (H)

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 1 summary submitted
  • 1 summary processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 7.1 µg/L (1)
Intermittent releases (freshwater) 0 ng/L (1)
Marine water 8.6 µg/L (1)
Intermittent releases (marine water) 0 ng/L (1)
Sewage treatment plant (STP) 330 µg/L (1)
Sediment (freshwater) 109 mg/kg sediment dw (1)
Sediment (marine water) 109 mg/kg sediment dw (1)
Hazard for Air
Air No hazard identified (1)
Hazard for Terrestrial Organism
Soil 29.9 mg/kg soil dw (1)
Hazard for Predators
Secondary poisoning 120 µg/kg food (1)

Short–term toxicity to fish

Study results
  • 125 studies submitted
  • 1 study processed
P/RResults
LC50 (4 days) 15.3 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 61 1
Weight of evidence
Other 9 53
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to fish

Study results
  • 30 studies submitted
  • 6 studies processed
P/RResults
NOEC (32 days) 35 - 431 000 µg/L [11]
NOEC (30 days) 108.9 µg/L [1]
NOEC (8 days) 40 - 80 µg/L [2]
LOEC (32 days) 35 - 3 730 µg/L [11]
LOEC (30 days) 433.5 µg/L [1]

Type of Study provided
Studies with data
Key study 7
Supporting study 6 1
Weight of evidence
Other 11 5
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Short–term toxicity to aquatic invertebrates

Study results
  • 160 studies submitted
  • 4 studies processed
P/RResults
LC50 (48 h) 13 - 276 µg/L [17]

Type of Study provided
Studies with data
Key study 4
Supporting study 77 10
Weight of evidence
Other 25 44
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 83 studies submitted
  • 24 studies processed
P/RResults
NOEC (8 months) 66 µg/L [1]
NOEC (4.233 months) 713 µg/L [1]
NOEC (56 days) 40 - 120 µg/L [2]
NOEC (42 days) 40 µg/L [2]
NOEC (36 days) 61 µg/L [1]

Type of Study provided
Studies with data
Key study 21 4
Supporting study 35
Weight of evidence
Other 17 6
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic algae and cyanobacteria

Study results
  • 86 studies submitted
  • 16 studies processed
P/RResults
EC50 (72 h) 40.7 - 1 430 µg/L [26]
IC50 (48 h) 456 - 4 400 µg/L [3]
NOEC (72 h) 3.5 - 5 476.8 µg/L [26]
NOEC (48 h) 10 - 110.5 µg/L [2]
LOEC (72 h) 6.2 - 11 551.3 µg/L [26]

Type of Study provided
Studies with data
Key study 5 11
Supporting study 22 2
Weight of evidence
Other 19 27
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic plants other than algae

Study results
  • 30 studies submitted
  • 1 study processed
P/RResults
EC50 (7 days) 87 - 1 377 µg/L [6]
EC10 (7 days) 3.9 - 435.3 µg/L [6]

Type of Study provided
Studies with data
Key study 1 1
Supporting study 7
Weight of evidence
Other 3 18
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to microorganisms

Study results
  • 59 studies submitted
  • 1 study processed
P/RResults
EC50 (30 min) 33 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 19
Weight of evidence
Other 3 36
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Sediment toxicity

Study results
  • 50 studies submitted
  • 25 studies processed
P/RResults
NOEC (4 days) 900 µg/L [1]
LOEC (4 days) 1.8 mg/L [1]
EC10 (56 days) 762 - 1 625 mg/kg sediment dw [2]
EC10 (49 days) 210 - 339 mg/kg sediment dw [3]
EC10 (42 days) 160 - 3 307 mg/kg sediment dw [4]

Type of Study provided
Studies with data
Key study 12
Supporting study 6
Weight of evidence 17
Other 12 3
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 39 studies submitted
  • 6 studies processed
P/RResults
NOEC (42 days) 20 - 180 mg/kg soil dw [4]
NOEC (28 days) 100 - 700 mg/kg soil dw [3]
NOEC (21 days) 180 - 800 mg/kg soil dw [4]
LOEC (42 days) 320 mg/kg soil dw [1]
LOEC (28 days) 300 - 1 000 mg/kg soil dw [3]

Type of Study provided
Studies with data
Key study 6
Supporting study 10 2 1
Weight of evidence
Other 15 5
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial arthropods

Study results
  • 18 studies submitted
  • 3 studies processed
P/RResults
NOEC (28 days) 36.4 - 1 140 mg/kg soil dw [2]
LOEC (28 days) 560 mg/kg soil dw [1]
EC50 (28 days) 476 mg/kg soil dw [1]
LC50 (8.167 months) 8 351 mg/kg diet [1]
LC50 (28 days) 1 g/kg soil dw [1]

Type of Study provided
Studies with data
Key study 3
Supporting study 3
Weight of evidence
Other 7 5
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial plants

Study results
  • 224 studies submitted
  • 14 studies processed
P/RResults
NOEC (63 days) 29 - 355 mg/kg soil dw [4]
NOEC (60 days) 88 - 187 mg/kg soil dw [2]
NOEC (56 days) 17 - 69 mg/kg soil dw [3]
NOEC (40 days) 67 mg/kg soil dw [1]
NOEC (30 days) 13 - 187 mg/kg soil dw [4]

Type of Study provided
Studies with data
Key study 14
Supporting study 41
Weight of evidence
Other 81 88
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to soil microorganisms

Study results
  • 37 studies submitted
  • 23 studies processed
P/RResults
NOEC (8.975 years) 86 mg/kg soil dw [2]
NOEC (1.381 years) 59 - 94 mg/kg soil dw [3]
NOEC (28 days) 41 mg/kg soil dw [1]
NOEC (7 days) 30 - 770 mg/kg soil dw [13]
EC10 (1.573 years) 295 mg/kg soil dw [1]

Type of Study provided
Studies with data
Key study 23
Supporting study 4
Weight of evidence
Other 6 4
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to birds

Study results
  • 9 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 3
Supporting study 2
Weight of evidence
Other 1 3
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 1 summary submitted
  • 1 summary processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 50 µg/m³ developmental toxicity / teratogenicity
Acute /short term: (DNEL) 104 mg/m³ acute toxicity
Local Effects
Long-term: (DNEL) 50 µg/m³ repeated dose toxicity
Acute /short term: (DNEL) 1.6 mg/m³ repeated dose toxicity
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
Local Effects
Long-term: (DNEL) 440 ng/cm² sensitisation (skin)
Acute /short term: No hazard identified
EYE Exposure
No hazard identified
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 60 ng/m³ developmental toxicity / teratogenicity
Acute /short term: (DNEL) 8.8 mg/m³ acute toxicity
Local Effects
Long-term: (DNEL) 60 ng/m³ repeated dose toxicity
Acute /short term: (DNEL) 100 µg/m³ repeated dose toxicity
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 11 µg/kg bw/day developmental toxicity / teratogenicity
Acute /short term: (DNEL) 370 µg/kg bw/day acute toxicity
EYE Exposure
No hazard identified

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 10 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 3
Supporting study 4
Weight of evidence
Other 1 2
Data waiving
no waivers
Study data: dermal absorption
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Acute toxicity

Study results
oral
  • 4 studies submitted
  • 2 studies processed
P/RResults
LD50 281 - 361.9 mg/kg bw (rat) [4]

Type of Study provided
oral
Studies with data
Key study
Supporting study 1
Weight of evidence 2
Other 1
Data waiving
no waivers
inhalation
  • 5 studies submitted
  • 1 study processed
P/RResults
LC50 (4 h) 2.48 mg/L air (rat) [1]

inhalation
Studies with data
Key study 1
Supporting study 2 1
Weight of evidence
Other 1
Data waiving
no waivers
dermal
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Irritation / corrosion

Study results
Study data: skin
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1 1
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: eye
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin
Adverse effect observed (irritating)
Eye
No adverse effect observed (not irritating)

Sensitisation

Study results
Study data: skin
  • 22 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study 12 1
Weight of evidence
Other 5 2
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: respiratory
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin sensitisation
Adverse effect observed (sensitising)

Repeated dose toxicity

Study results
Study data: oral
  • 14 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Study data: oral
Studies with data
Key study 1
Supporting study 4 1
Weight of evidence
Other 6 2
Data waiving
no waivers
Study data: inhalation
  • 14 studies submitted
  • 0 studies processed

No automatically processable data submitted

Study data: inhalation
Studies with data
Key study 2
Supporting study 5 2
Weight of evidence
Other 3 2
Data waiving
no waivers
Study data: dermal
  • 5 studies submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence 1
Other 4
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Genetic toxicity

Study results
Study data: in vitro
  • 37 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 2
Supporting study 10
Weight of evidence 4
Other 19 2
Data waiving
no waivers
Study data: in vivo
  • 9 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 1
Supporting study 3
Weight of evidence 3
Other 2
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Carcinogenicity

Study results
  • 16 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 3
Supporting study 2 2
Weight of evidence 1
Other 4 4
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to reproduction

Study results
Study data: reproduction
  • 15 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 2
Supporting study 3 2
Weight of evidence
Other 5 1 2
Data waiving
no waivers
Study data: developmental
  • 8 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 2
Supporting study 1 2
Weight of evidence 1
Other 1 1
Data waiving
no waivers
Study data: other studies
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1 1
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Neurotoxicity

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Immunotoxicity

Study results
  • 7 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study 2
Weight of evidence 1
Other 4
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant