Brief Profile

Diss Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
203-632-7
CAS no.:
108-95-2
Index number:
604-001-00-2
Molecular formula:
C6H6O
SMILES:
OC1=CC=CC=C1
InChI:
InChI=1S/C6H6O/c7-6-4-2-1-3-5-6/h1-5,7H
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
28
Of which contain:
9 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Danger! According to the harmonised classification and labelling (CLP00) approved by the European Union, this substance is toxic if swallowed, is toxic in contact with skin, causes severe skin burns and eye damage, is toxic if inhaled, is suspected of causing genetic defects and may cause damage to organs through prolonged or repeated exposure.

Additionally, the classification provided by companies to ECHA in REACH registrations identifies that this substance is toxic to aquatic life with long lasting effects.

Additionally, the classification provided by companies to ECHA in CLP notifications identifies that this substance causes serious eye damage.

Breakdown of all 4198 C&L notifications submitted to ECHA

Acute Tox. 3 H311 Harmonised Classification
Acute Tox. 3 H301 Harmonised Classification
Acute Tox. 3 H331 Harmonised Classification
Skin Corr. 1B H314 Harmonised Classification
STOT RE 2 H373 Harmonised Classification
Muta. 2 H341 Harmonised Classification
Eye Dam. 1 H318
Aquatic Chronic 2 H411
STOT SE 1 H370
STOT SE 2 H371
Eye Irrit. 2 H319
STOT RE 1 H372
Skin Corr. 1 H314
Aquatic Chronic 1 H410
Acute Tox. 1 H330
https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/more.png 0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

  • M
Suspected to be Mutagenic (Harmonised C&L).

Regulatory context

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 106 active registrations under REACH, 2 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Registration dossiers submitted to ECHA for this substance have been evaluated under REACH.
Substance Evaluation:
Substance included in the Community Rolling Action Plan (CoRAP).
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Persistent Organic Pollutants Regulation (POPs)

List of substances subject to the POPs Regulation:
List of substances proposed as POPs:

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Seveso Annex I:
Industrial accident prevention and reporting requirements have been established for this substance.
Notified C&L:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 1 000 000 to < 10 000 000 tonnes per annum.

This substance is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

This substance is used in the following activities or processes at workplace: the low energy manipulation of substances bound in materials or articles and closed processes with no likelihood of exposure.

Other release to the environment of this substance is likely to occur from: outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials) and indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment).

This substance can be found in complex articles, with no release intended: machinery, mechanical appliances, electrical/electronic products not covered by Waste Electrical and Electronic Equipment (WEEE) directive (e.g. large-scale stationary industrial tools) and machinery, mechanical appliances and electrical/electronic products (e.g. computers, cameras, lamps, refrigerators, washing machines). This substance can be found in products with material based on: leather (e.g. gloves, shoes, purses, furniture).

This substance is used in the following products: fertilisers and polymers.

This substance is used in the following areas: scientific research and development. This substance is used for the manufacture of: chemicals and plastic products.

This substance is used in the following activities or processes at workplace: transfer of chemicals, roller or brushing applications, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure and mixing in open batch processes.

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed batch processing in synthesis or formulation, transfer of substance into small containers, production of mixtures or articles by tabletting, compression, extrusion or pelletisation, closed processes with no likelihood of exposure and treatment of articles by dipping and pouring.

Release to the environment of this substance can occur from industrial use: formulation of mixtures, in processing aids at industrial sites, formulation in materials and in the production of articles.

This substance is used in the following products: polymers.

This substance is used in the following areas: scientific research and development. This substance is used for the manufacture of: chemicals, plastic products and rubber products.

This substance is used in the following activities or processes at workplace: transfer of chemicals, mixing in open batch processes, roller or brushing applications, treatment of articles by dipping and pouring and manual maintenance (cleaning and repair) of machinery.

Release to the environment of this substance can occur from industrial use: as an intermediate step in further manufacturing of another substance (use of intermediates), in processing aids at industrial sites, for thermoplastic manufacture, as processing aid and in the production of articles.

This substance is used in the following activities or processes at workplace: transfer of chemicals, batch processing in synthesis or formulation with opportunity for exposure, closed batch processing in synthesis or formulation and mixing in open batch processes.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: do not get in eyes, on skin, or on clothing; use personal protective equipment as required.; avoid release to the environment.

Response statements

In case of incident: If exposed or you feel unwell: call a poison center or doctor/physician. If in eyes: rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing. If on skin: wash with soap and water.

Storage statements

Store this substance locked up.

Disposal statements

The substance must be disposed in accordance with local/regional/national/international regulation.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • 3M Belgium BVBA/SPRL, Hermeslaan 7 1831 Diegem Belgium
  • 3M France SAS, 1 Parvis de l'Innovation CS 20203 95006 Cergy-Pontoise Cedex France
  • A V Pound & Co. Ltd, Goolds Hill House Old Cork Road Ireland Mallow Co. Cork Ireland
  • AdvanSix Resins & Chemicals (Ireland) Limited, 13-18 City Quay D02 ED70 Dublin Ireland Ireland
  • Afton Chemical S.R.L. (Woluwe), Alma Court Lenneke Marelaan, 8 B-1932 St-Stevens-Woluwe Belgium
  • Allnex Belgium NV/SA OR1, Anderlechtstraat 33 1620 Drogenbos Belgium
  • ALTIS INTERNATIONAL BELGIUM BV , Desguinlei 88A 2018 Antwerpen Belgium
  • Arcerion GmbH, Gabrielenstr. 15 80636 München Germany
  • Archroma Germany GmbH, Kasteler Str. 45 65203 Wiesbaden Germany
  • ARCHROMA IBÉRICA, S.L., ZAL-Prat c/Cal Coracero, 46-56 08820 El Prat de Llobregat Spain
  • BCS Only Representative Services Ltd, Pembroke House 30 Upper Pembroke Street Dublin 2 Dublin Ireland
  • Blue Cube Germany Assets GmbH & Co. KG, Buetzflether Sand 2 21683 Stade Germany
  • Blue Cube Netherlands B.V., Axelsedam 3a 4531HH Terneuzen Netherlands
  • Blue Cube Netherlands B.V. – OR1, Axelsedam 3a 4531HH Terneuzen Netherlands
  • Borealis AG, Wagramerstrasse 17-19 1220 Wien Austria
  • Borealis Polymers Oy, P.O. Box 330 06101 Porvoo Finland
  • Cambridge Environmental Assessments part of RSK ADAS Europe (Ireland) Ltd, Office Suite B, Bluebell Business Centre Old Naas road D12XV7K Dublin Ireland
  • Caplinq Europe BV, De Trompet 1126 1967 DA Heemskerk - Netherlands
  • Caplinq Europe BV, Industrieweg 15E 1566JN Assendelft - Netherlands
  • Cardolite Specialty Chemicals Europe NV (OR for IXE), Wijmenstraat 21 K bus 2 B-9030 Mariakerke (Gent) Belgium
  • CCD (Germany) GmbH, Berliner Allee 55 40212 Düsseldorf Germany
  • CEPSA Química, S.A., Torre CEPSA Paseo de Castellana 259A 28046 Madrid Spain
  • Chemservice GmbH - (7AYP), Herrnsheimer Hauptstrasse 1b 67550 Worms Germany
  • Chevron Oronite SA - OR - CVX Japan Ltd, Le Corosa 1, rue Eugène et Armand Peugeot CS10022 92508 Rueil-Malmaison Cedex France
  • Chevron Oronite SA M/I, Le Corosa 1, rue Eugène et Armand Peugeot CS10022 92508 Rueil-Malmaison Cedex France
  • COVANCE CLINICAL DEVELOPMENT SA 087, Parque Empresarial Las Tablas, Edificio 1 Calle Federico Mompou, 5 – 5 Planta 28050 Madrid Spain
  • Covestro Deutschland AG, Kaiser-Wilhelm-Allee 60 51373 Leverkusen Germany
  • Covestro NV, Haven 507 Scheldelaan 420 2040 Antwerpen Belgium
  • Covestro Procurement Services GmbH & Co. KG, Kaiser-Wilhelm-Allee 60 51373 Leverkusen Germany
  • Cytec Engineered Materials GmbH in its legal capacity as OR of Cytec Industries Inc., Industriestraße 3 76684 Östringen Germany
  • DEZA a.s., Masarykova 753 75701 Valasske Mezirici Czech Republic
  • DOMO Caproleuna GmbH, Am Haupttor Bau 3101 06237 Leuna Germany
  • DuPont Specialty Products GmbH & Co. KG, Hugenottenallee 175 63263 Neu-Isenburg Hesse Germany
  • ExponentOR11I, Block 1, Blanchardstown Corporate Park Ballycoolen Road, Blanchardstown D15 AKK1 Dublin Ireland
  • Global Product Compliance (Europe) AB, IDEON, Beta 5, Scheelevägen 17 22363 Lund Sweden
  • Global Product Compliance (Europe) AB, IDEON, Beta 5, Scheelevägen 17 223 63 Lund Sweden
  • Henkel Global Supply Chain B.V., Gustav Mahlerlaan 2970 1081 LA Amsterdam Netherlands
  • Hexion B.V., Seattleweg 17, building 4 3195 ND Pernis-Rotterdam Netherlands
  • Hexion GmbH, Gennaer Strasse 2-4 D-58642 Iserlohn North Rhine-Westphalia Germany
  • Hexion Italia S.r.l., Via Mazzini, 104 21058 Solbiate Olona, VA Italy
  • Huntsman Advanced Materials (Europe) BV, Everslaan 45 B-3078 Everberg Belgium
  • INEOS Composites Hispania S.L. (0341), Partida Povet, 37 ES-12580 Benicarlo Castellón de la Plana Spain
  • INEOS Phenol Belgium N.V., Haven 1930, Geslecht 1 9130 Beveren Belgium
  • INEOS Phenol GmbH, Dechenstrasse 3 45966 Gladbeck Germany
  • Lanxess Deutschland GmbH, Kennedyplatz 1 50569 Köln Germany
  • LANXESS Sales Netherlands B.V., Groot Egtenrayseweg 23 5928 PA Venlo Netherlands
  • LG Chem Europe GmbH, Alfred Herrhausen Allee 3 5 D-65760 Eschborn Germany
  • Lubrizol France SAS, 25 Quai de France 76100 ROUEN France
  • Luxcontrol S.A. (OR 60), 1, Avenue des Terres Rouges 4331 Esch-sur-Alzette Luxembourg
  • M-Chemicals s.r.o., Dvořákovo nábrežie 4A 81102 Bratislava Slovakia
  • Mitsui and Co. Deutschland G.M.B.H. Head Office (Düsseldorf), Herzogstrasse 15 D-40217 Düsseldorf Germany
  • Monument Chemical, Haven 1972 Ketenislaan 3 9130 Kallo Belgium
  • NOVAPEX, 21 chemin de la Sauvegarde « 21 Ecully Parc » CS 33167 69134 ECULLY Cedex France
  • NWL FRANCE SERVICES, 122 avenue du Général Leclerc 92100 Boulogne Billancourt France France
  • Only representative (No publishable name), null
  • Polski Koncern Naftowy ORLEN SA, ul. Chemików 7 09-411 Płock Poland
  • PPG Europe B.V. - OR1, Amsterdamseweg 14 1422 AD Uithoorn Netherlands
  • PPG Europe B.V. in its legal capacity as Only Representative of PRC DeSoto International Inc. - OR5, Amsterdamseweg 14 1422 AD Uithoorn Netherlands
  • Prefere Resins Finland Oy, Öljysatamantie 16 49401 Hamina Finland
  • Prefere Resins France, 10, Rue Comtesse F-62117 Brebieres France
  • Prefere Resins Germany GmbH, Dr.-Hans-Lebach-Straße 7 D-15537 Erkner Germany
  • Rain Carbon Germany GmbH, Kekulestr. 30 44579 Castrop-Rauxel Germany
  • Ramboll Deutschland GmbH, Werinherstraße 79 Gebäude 32a 81541 München Bayern Germany
  • Reach Only Representative (Ireland) Ltd (Macres), VPR House Main Street F12 FC64 Swinford County Mayo Ireland
  • REACH24H CONSULTING GROUP, Suite 1E, Paramount Court, Corrig Road, Sandyford Dublin 18 Dublin Ireland
  • REACH24H CONSULTING GROUP, Paramount Court, Corrig Road, Sandyford Dublin18 Dublin Ireland
  • REACH24H CONSULTING GROUP, Suite 1E, Paramount Court, Corrig Road, Sandyford, Dublin 18, Ireland Dublin 18 Dublin Ireland
  • REACHLaw Ltd, Vänrikinkuja 3 JK 21 02600 Espoo Finland
  • REACHLaw Ltd., Vänrikinkuja 3 JK 21 02600 Espoo Finland
  • REACHLaw Ltd., Vänrikinkuja 3 JK 21 FI-02600 Espoo Finland
  • Red Orchid Consulting Oy Ltd, Viherkallionkuja 3 I 59 02710 Espoo Finland
  • REGARTIS s.r.o., Rubeška 393/7 19000 Prague Czech Republic
  • RHODIA OPERATIONS - 1, 52 rue de la Haie Coq 93300 Aubervilliers France
  • SABIC Innovative Plastics BV, Plasticslaan 1 4612 PX Bergen op Zoom Netherlands Netherlands
  • SABIC Petrochemicals B.V., Europaboulevard 1 6135 LD Sittard Limburg Netherlands
  • Sasol Chemie GmbH & Co. KG, Anckelmannsplatz 1 20537 Hamburg Germany
  • SCAS Europe S.A./N.V., Leonardo Da Vincilaan 19 B-1831 Diegem Belgium
  • Shell Chemicals Europe B.V., Weena 70 3012 CM Rotterdam Netherlands
  • SHPP B.V., Plasticslaan 1 4612PX Bergen op Zoom Netherlands
  • SI Group-Béthune S.A.S., 1111 Avenue George Washington Boite Postale 237 62404 Cedex Béthune France
  • SIGMA-ALDRICH CHEMIE GMBH, Riedstrasse 2 89555 Steinheim Germany
  • SIGMA-ALDRICH CHIMIE SARL, 80 Rue de Luzais BP 701 38297 Saint Quentin Fallavier France
  • Silvachimica s.r.l., Via torre 7 12080 San Michele Mondovì Cuneo Italy
  • Stahl Europe B.V., Sluisweg 10 5145PE Waalwijk Noord Brabant Netherlands
  • Sumitomo Deutschland GmbH, Schwannstraße 10 40476 Düsseldorf Germany
  • TFL Ledertechnik GmbH, Peter-Krauseneck-Strasse 16 79618 Rheinfelden Germany
  • TsafeE GmbH, Landwehrplatz 6 66111 Saarbruecken Germany
  • TÜV SÜD Iberia S.A.U. (003), Ronda Can Fatjó 13 08290 Cerdanyola del Vallès Barcelona Spain
  • TÜV SÜD Iberia S.A.U. (054), Ronda Can Fatjó 13 08290 Cerdanyola del Vallès Barcelona Spain
  • Valspar b.v., Zuiveringweg 89 8243 PE Lelystad Netherlands
  • Valtris Enterprises France (OR-UK), ZI Baleycourt 55103 Verdun France
  • versalis S.p.A., P.zza Boldrini 1 20097 San Donato Milanese MILANO Italy
  • Vyncolit NV (OR SBNA), Wiedauwkaai 6 9000 Gent Belgium
  • [Confidential], [Confidential]
  • BASF SE, Carl-Bosch-Str. 38 67056 Ludwigshafen am Rhein Rheinland-Pfalz Germany
  • Dow Silicones Belgium SPRL OR-2, PSRC - rue Jules Bordet Parc industriel C 7180 Seneffe Belgium
  • Envigo Research Limited 212, Shardlow Business Park London Road DE72 2GD Shardlow Derbyshire United Kingdom
  • Henkel Electronic Materials (Belgium) N.V., Nijverheidsstraat 7 2260 Westerlo Belgium
  • Henkel Italia Operations S.r.L., Via Amoretti 78 20157 Mailand Italy
  • SABIC Innovative Plastics Espana ScpA, Ctra. Cartagena-Alhama de Murcia km. 13. La Aljorra 30390 Cartagena Spain Spain
  • SLOVNAFT, a.s., Vlcie hrdlo 1 824 12 Bratislava Slovakia

Substance names and other identifiers

carbolic acid
C&L Inventory
monohydroxybenzene
C&L Inventory
Phenol
EC Inventory, C&L Inventory, REACH pre-registration, Other, Cosmetic Products Regulation, Annex II - Prohibited Substances, Occupational Exposure Limits - 3rd list - Indicative OELVs, FCM and Articles Regulation, Annex I - Authorised Substances, FCMs Recycled Plastic & Articles Regulation - Annex I - Authorised Use, Toy Safety Directive - Substances Restricted in Toys
Phenol
C&L Inventory, Substance Evaluation - CoRAP, REACH pre-registration, Other, Cosmetic Products Regulation, Annex II - Prohibited Substances, Occupational Exposure Limits - 3rd list - Indicative OELVs, FCM and Articles Regulation, Annex I - Authorised Substances, FCMs Recycled Plastic & Articles Regulation - Annex I - Authorised Use, Toy Safety Directive - Substances Restricted in Toys
PHENOL SOLUTION
Inland Transport of Dangerous Goods Directive, Annex III - ADN, Inland Transport of Dangerous Goods Directive, Annex I - ADR, Inland Transport of Dangerous Goods Directive, Annex II - RID
PHENOL, MOLTEN
Inland Transport of Dangerous Goods Directive, Annex III - ADN, Inland Transport of Dangerous Goods Directive, Annex I - ADR, Inland Transport of Dangerous Goods Directive, Annex II - RID
PHENOL, SOLID
Inland Transport of Dangerous Goods Directive, Annex III - ADN, Inland Transport of Dangerous Goods Directive, Annex I - ADR, Inland Transport of Dangerous Goods Directive, Annex II - RID
phenol; carbolic acid; monohydroxybenzene; phenylalcohol
FCM Active and Intelligent Materials - CMRs not allowed for use, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, End-of-Life Vehicles Directive - Hazardous Substances, Active Implantable Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, Protection of Pregnant and Breastfeeding Workers Directive, Annex I+II, Pressure Equipment Directive - Group 1 Fluids Hazardous Substances, General Product Safety Directive - Hazardous Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Carc and Muta Directive, Annex I - Substances, Mixtures & Processes, Physical, Biological and Chemical Agents & Processes and Work
phenylalcohol
C&L Inventory
acid carbolic (ro)
C&L Inventory
fenil-alkohol (hr)
C&L Inventory
fenilalcohol (es)
C&L Inventory
fenilalcool (ro)
C&L Inventory
fenilalkohol (hu)
C&L Inventory
fenilalkohol (sl)
C&L Inventory
fenilalkoholis (lt)
C&L Inventory
fenilspirts (lv)
C&L Inventory
fenol (cs)
C&L Inventory
fenol (da)
C&L Inventory
fenol (es)
C&L Inventory
fenol (hr)
C&L Inventory
fenol (hu)
C&L Inventory
fenol (nl)
C&L Inventory
fenol (no)
C&L Inventory
Fenol (pl)
C&L Inventory
fenol (pt)
C&L Inventory
fenol (ro)
C&L Inventory
fenol (sk)
C&L Inventory
fenol (sl)
C&L Inventory
fenol (sv)
C&L Inventory
Fenoli (fi)
C&L Inventory
fenolis (lt)
C&L Inventory
fenolo (it)
C&L Inventory
fenols (lv)
C&L Inventory
fenool (et)
C&L Inventory
fenylalkohol (sk)
C&L Inventory
fenylalkohol (sv)
C&L Inventory
fenüülalkohol (et)
C&L Inventory
hidroxibenceno (es)
C&L Inventory
Hydroksybenzen (pl)
C&L Inventory
karbolhape (et)
C&L Inventory
karbolio rūgštis (lt)
C&L Inventory
karbolna kiselina (hr)
C&L Inventory
karbolna kislina (sl)
C&L Inventory
karbolová kyselina (cs)
C&L Inventory
karbolsav (hu)
C&L Inventory
karbolskābe (lv)
C&L Inventory
Karbolsäure (de)
C&L Inventory
kyselina karbolová (sk)
C&L Inventory
monohidroksibenzen (hr)
C&L Inventory
monohidroksibenzen (sl)
C&L Inventory
monohidroksibenzenas (lt)
C&L Inventory
monohidroksibenzols (lv)
C&L Inventory
monohidroxibenzen (ro)
C&L Inventory
monohidroxibenzeno (pt)
C&L Inventory
monohidroxibenzol (hu)
C&L Inventory
Monohydroxybenzene (de)
C&L Inventory
monohydroxybenzén (sk)
C&L Inventory
monohüdroksübenseen (et)
C&L Inventory
phenol (da)
C&L Inventory
Phenol (de)
C&L Inventory
Phenylalcohol (de)
C&L Inventory
phénol; acide carbolique; monohydroxybenzène; phényléthanol (fr)
C&L Inventory
ácido carbólico (es)
C&L Inventory
ácido carbólico (pt)
C&L Inventory
álcool fenílico (pt)
C&L Inventory
φαινόλh (el)
C&L Inventory
карболова киселина (bg)
C&L Inventory
монохидроксибензен (bg)
C&L Inventory
фенилалкохол (bg)
C&L Inventory
фенол (bg)
C&L Inventory
Phenol
Other
acide carbolique
C&L Inventory
Benzenol
C&L Inventory
carbolic acid
C&L Inventory
fenolo
C&L Inventory
Hydroxybenzene
C&L Inventory
Hydroxybenzene, Carbolic acid
Registration dossier
Monohydroxybenzene
C&L Inventory
PHENOL
C&L Inventory, Registration dossier, Other
Phenol
C&L Inventory, Registration dossier, Other
Phenol - ML0107B
Registration dossier
phenol carbolic acid monohydroxybenzene phenylalcohol
C&L Inventory
Phenol, pure
C&L Inventory
phenolphenol
C&L Inventory
phenylalcohol
C&L Inventory
Public name for Phenol Pur F900B is phenol; public name for Phenol Tech F900A is diacetone alcohol
Registration dossier
(Mono)hydroxybenzene
Registration dossier
ACIDO CARBOLICO
Registration dossier
Acido fenico
Registration dossier
Acido fenico - Idrossibenzene
Registration dossier
Benzenol
Registration dossier
Benzyl Alcohol
Registration dossier
Carbolic acid
Registration dossier
Carbolsaeure
Registration dossier
Carbolsäure, Karbolsäure, Monohydroxybenzol,
Registration dossier
Carbolsäure, Karbolsäure, Monohydroxybenzol, Phenylalkohol, Benzophenol
Registration dossier
CARBOLZUUR HYDROXY BENZEEN
Registration dossier
CARBONATE OLIGOMER OF TETRABROMOBISPHENOL A
Registration dossier
fenol
Registration dossier
fenolo
Registration dossier
HIDROXIBENCENO
Registration dossier
hydrate; phenylic acid; Fenolo (Italian)
Registration dossier
Hydroxybenzene
Registration dossier
Hydroxybenzene; oxybenzene; phenic acid; phenyl
Registration dossier
Hydroxybenzene; oxybenzene; phenic acid; phenyl hydrate; phenylic acid; Fenolo (Italian)
Registration dossier
Hydroxybenzol,Benzophenol,Karbolsäure
Registration dossier
Idrossido di fenile
Registration dossier
Karbolsaeure
Registration dossier
MONOHIDROXIBENCENO
Registration dossier
Monohydroxybenzene
Registration dossier
Monohydroxybenzol
Registration dossier
Monoidrossibenzene
Registration dossier
Oxybenzene
Registration dossier
Phenic acid
Registration dossier
phenic acid, carbolic acid, phenyl hydroxide,
Registration dossier
phenic acid, carbolic acid, phenyl hydroxide, hydroxybenzene
Registration dossier
PHENOL
Registration dossier
Phenol Pur F900A
Registration dossier
Phenol Pur F900B
Registration dossier
phenol synthetic, technical
Registration dossier
Phenol Synthetical Technical, A type
Registration dossier
PHENOL,CARBOLIC ACID, PHENYL HYDROXIDE
Registration dossier
phenyl hydrate
Registration dossier
phenyl hydroxide
Registration dossier
Phenylalcohol
Registration dossier
Phenylalkohol, Benzophenol
Registration dossier
Phenylhydroxide
Registration dossier
phenylic acid
Registration dossier
phenylic alcohol
Registration dossier
Phenylsaeure
Registration dossier
PhOH
Registration dossier
108-95-2
CAS number
EC Inventory, C&L Inventory, Substance Evaluation - CoRAP, Registration dossier, REACH pre-registration, Other, FCM Active and Intelligent Materials - CMRs not allowed for use, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, Cosmetic Products Regulation, Annex II - Prohibited Substances, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, End-of-Life Vehicles Directive - Hazardous Substances, Active Implantable Medical Devices Directive - Hazardous Substances, Inland Transport of Dangerous Goods Directive, Annex III - ADN, Inland Transport of Dangerous Goods Directive, Annex I - ADR, Inland Transport of Dangerous Goods Directive, Annex II - RID, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, Occupational Exposure Limits - 3rd list - Indicative OELVs, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, FCM and Articles Regulation, Annex I - Authorised Substances, Protection of Pregnant and Breastfeeding Workers Directive, Annex I+II, Pressure Equipment Directive - Group 1 Fluids Hazardous Substances, General Product Safety Directive - Hazardous Substances, FCMs Recycled Plastic & Articles Regulation - Annex I - Authorised Use, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Toy Safety Directive - Substances Restricted in Toys, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Carc and Muta Directive, Annex I - Substances, Mixtures & Processes, Physical, Biological and Chemical Agents & Processes and Work
14534-23-7
CAS number
Other
14534-23-7
Deleted CAS number
Other
50356-25-7
CAS number
Other
50356-25-7
Deleted CAS number
Other
604-001-00-2
Index number
C&L Inventory
8002-07-1
CAS number
Other
8002-07-1
Deleted CAS number
Other

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 1 study submitted
  • 1 study processed
C Physical state at 20°C and 1013 hPa
Solid (100%) [1]
C Form
Crystalline (100%) [1]
C Odour
Characteristic of aromatic compounds (100%) [1]
C Substance type
Organic (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Physical state at 20°C and 1013 hPa
Solid (100%)

Melting/freezing point

Study results
  • 6 studies submitted
  • 3 studies processed
R Melting / freezing point
40.9 °C @ 101.3 kPa [3]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 3
Other 3
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Melting / freezing point at 101 325 Pa
40.9 °C

Boiling point

Study results
  • 5 studies submitted
  • 2 studies processed
R Boiling point
181.8 - 181.9 °C @ 101.3 kPa [2]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 2
Other 3
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Boiling point at 101 325 Pa
181.8 °C

Density

Study results
  • 5 studies submitted
  • 2 studies processed
R Density
1.07 - 1.13 g/cm³ @ 20 - 25 °C [2]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 2
Other 3
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Vapour pressure

Study results
  • 5 studies submitted
  • 1 study processed
R Vapour pressure
20 - 100 Pa @ 20 - 36.1 °C [2]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 4
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Vapour pressure
20 Pa @ 20 °C

Partition coefficient

Study results
  • 2 studies submitted
  • 1 study processed
R Log Pow
1.47 @ 30 °C and pH 3 - 8 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Log Kow (Log Pow)
1.47 @ 30 °C

Water solubility

Study results
  • 6 studies submitted
  • 2 studies processed
R Water solubility (mass/vol.)
69 - 97.8 g/L @ 2.6 - 40 °C [6]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 2
Other 4
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Water solubility
84 g/L @ 20 °C

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Surface tension at 20 °C
71.3 mN/m @ 1 260 mg/L

Flash point

Study results
  • 6 studies submitted
  • 1 study processed
R Flash point
81 °C @ 101.3 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 5
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Flash point at 101 325 Pa
81 °C

Auto flammability

Study results
  • 7 studies submitted
  • 1 study processed
R Autoflammability / self-ignition
715 °C @ 101.3 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 6
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Autoflammability / self-ignition at 101 325 Pa
715 °C

Flammability

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Flammability
Non flammable (100%)

Explosiveness

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 3
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
C Summaries
  • 1 summary submitted
  • 1 summary processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
C Summaries
  • 1 summary submitted
  • 1 summary processed
Oxidising
No (100%)

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 1 study submitted
  • 1 study processed
C Dissociating properties
Yes (100%) [1]
R Dissociation constant
9.89 @ 20 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
pKa at 20 °C
9.9

Viscosity

Study results
  • 1 study submitted
  • 1 study processed
R dynamic viscosity (in mPa s)
1.784 - 3.437 [2]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 5 studies submitted
  • 1 study processed
R Dissipation half life (DT50)
11 - 14 h [2]

Type of Study provided
Studies with data
Key study 1
Supporting study 1 1
Weight of evidence
Other 1 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half life in air
14 h

Hydrolysis

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in water

Study results
  • 12 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 10 1
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in soil

Study results
  • 0 studies submitted
  • 0 studies processed

No data available

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in water - screening tests

Study results
  • 8 studies submitted
  • 1 study processed
C Interpretation of results
Readily biodegradable (100%) [1]

Type of Study provided
Studies with data
Key study 3
Supporting study 3 1
Weight of evidence
Other 1
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Biodegradation in water
Readily biodegradable (100%)

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in soil

Study results
  • 7 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 3 3
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: aquatic / sediment

Study results
  • 16 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study 3 1
Weight of evidence
Other 10 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Bioaccumulation Factor (BCF) - dimensionless
17.5

Bioaccumulation: terrestrial

Study results
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Adsorption/desorption

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other 1 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Koc at 20°C
82.8

Henrys law constant (H)

Study results
  • 2 studies submitted
  • 1 study processed
R H - (pressure) m³/mol
0.022 Pa m³/mol @ 20 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Henry's law constant
0.022 Pa.m³.mol-1 @ 20 °C

Distribution modelling

Study results
  • 2 studies submitted
  • 1 study processed
% Distribution in Media:
R Air 0.8 % [1]
R Water 98.8 % [1]
R Soil 0.2 % [1]
R Sediment 0.2 % [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers

No summary exists for this scientific endpoint

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 1 summary submitted
  • 1 summary processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 7.7 µg/L (1)
Intermittent releases (freshwater) 31 µg/L (1)
Marine water 770 ng/L (1)
Intermittent releases (marine water) -
Sewage treatment plant (STP) 2.1 mg/L (1)
Sediment (freshwater) 91.5 µg/kg sediment dw (1)
Sediment (marine water) 9.15 µg/kg sediment dw (1)
Hazard for Air
Air No hazard identified (1)
Hazard for Terrestrial Organism
Soil 136 µg/kg soil dw (1)
Hazard for Predators
Secondary poisoning No potential for bioaccumulation (1)

Short–term toxicity to fish

Study results
  • 30 studies submitted
  • 3 studies processed
P/RResults
LC50 (14 days) 21.93 mg/L [1]
LC50 (4 days) 8.9 - 67.5 mg/L [3]
LC100 (14 days) 16 mg/L [1]
NOEC (14 days) 4 mg/L [1]

Type of Study provided
Studies with data
Key study 3
Supporting study 1
Weight of evidence
Other 25 1
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to fish

Study results
  • 11 studies submitted
  • 1 study processed
P/RResults
NOEC (60 days) 77 µg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 9
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Short–term toxicity to aquatic invertebrates

Study results
  • 23 studies submitted
  • 1 study processed
P/RResults
EC50 (48 h) 3.1 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other 18 2
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 7 studies submitted
  • 1 study processed
P/RResults
NOEC (16 days) 160 µg/L [1]
EC10 (16 days) 460 µg/L [1]
EC50 (16 days) 10 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other 4
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic algae and cyanobacteria

Study results
  • 16 studies submitted
  • 1 study processed
P/RResults
EC50 (4 days) 61.1 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other 13
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for freshwater algae
61.1 mg/L
EC50 for marine water algae
76 mg/L

Toxicity to aquatic plants other than algae

Study results
  • 4 studies submitted
  • 2 studies processed
P/RResults
EC50 (7 days) 61.82 - 1 981.8 mg/L [16]
EC10 (7 days) 5.92 - 37.1 mg/L [3]

Type of Study provided
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for freshwater plants
61.82 mg/L
EC10 or NOEC for freshwater plants
5 mg/L

Toxicity to microorganisms

Study results
  • 15 studies submitted
  • 1 study processed
P/RResults
IC50 (24 h) 21 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other 11 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for microorganisms
21 mg/L

Sediment toxicity

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 3 studies submitted
  • 1 study processed
P/RResults
LC50 (14 days) 401 mg/kg soil dw [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
R Summaries
  • 1 summary submitted
  • 1 summary processed
Short-term EC50 / LC50
401 mg/kg soil dw

Toxicity to terrestrial arthropods

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial plants

Study results
  • 7 studies submitted
  • 1 study processed
P/RResults
EC50 (14 days) 79 mg/kg soil dw [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 5
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
R Summaries
  • 1 summary submitted
  • 1 summary processed
Short-term EC50 / LC50
79 mg/kg soil dw

Toxicity to soil microorganisms

Study results
  • 2 studies submitted
  • 1 study processed
P/RResults
EC10 (14 days) 100 mg/kg soil dw [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to birds

Study results
  • 2 studies submitted
  • 1 study processed
P/RResults
LD50 (18 h) 113 mg/kg bw [1]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 1
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 1 summary submitted
  • 1 summary processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 8 mg/m³ -
Acute /short term: Medium hazard (no threshold derived)
Local Effects
Long-term: Low hazard (no threshold derived)
Acute /short term: (DNEL) 16 mg/m³ -
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 1.23 mg/kg bw/day -
Acute /short term: Medium hazard (no threshold derived)
Local Effects
Long-term: Medium hazard (no threshold derived)
Acute /short term: High hazard (no threshold derived)
EYE Exposure
High hazard (no threshold derived)
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 452 µg/m³ -
Acute /short term: - -
Local Effects
Long-term: Hazard unknown (no further information necessary as no exposure expected)
Acute /short term: - -
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 500 µg/kg bw/day -
Acute /short term: - -
Local Effects
Long-term: High hazard (no threshold derived)
Acute /short term: - -
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 500 µg/kg bw/day -
Acute /short term: - -
EYE Exposure
High hazard (no threshold derived)

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 12 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 3
Supporting study
Weight of evidence
Other 9
Data waiving
no waivers
Study data: dermal absorption
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Acute toxicity

Study results
oral
  • 7 studies submitted
  • 2 studies processed
P/RResults
LD50 340 - 650 mg/kg bw (rat) [4]

Type of Study provided
oral
Studies with data
Key study
Supporting study
Weight of evidence 2
Other 5
Data waiving
no waivers
inhalation
  • 4 studies submitted
  • 1 study processed
P/RResults
LC0 (8 h) 900 mg/m³ air (rat) [1]

inhalation
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 3
Data waiving
no waivers
dermal
  • 4 studies submitted
  • 1 study processed
P/RResults
LD50 0.625 mL/kg bw (rat) [1]

dermal
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 2
Data waiving
no waivers
other routes
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other 3
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Irritation / corrosion

Study results
Study data: skin
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study
Supporting study 2
Weight of evidence 2
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: eye
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 1
Supporting study
Weight of evidence 1
Other 3
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin
Adverse effect observed (corrosive)
Eye
Adverse effect observed (irritating)

Sensitisation

Study results
Study data: skin
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study
Supporting study
Weight of evidence 2
Other 2
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin sensitisation
No adverse effect observed (not sensitising)

Repeated dose toxicity

Study results
Study data: oral
  • 9 studies submitted
  • 4 studies processed
P/RResults
NOAEL (rat): 1 000 - 5 000 ppm [3]
NOAEL (mouse): 5 000 ppm [1]
LOAEL (rat): 5 000 ppm [1]
NOEL (rat): 200 ppm [1]
LOEL (rat): 2 500 - 5 000 ppm [2]

Type of Study provided
Study data: oral
Studies with data
Key study
Supporting study
Weight of evidence 4
Other 2 3
Data waiving
no waivers
Study data: inhalation
  • 4 studies submitted
  • 2 studies processed
P/RResults
NOAEC (rat): 25 ppm [1]
NOAEC (monkey): 5 ppm [1]

Study data: inhalation
Studies with data
Key study
Supporting study 1
Weight of evidence 2
Other 1
Data waiving
no waivers
Study data: dermal
  • 2 studies submitted
  • 1 study processed
P/RResults
NOAEL (rabbit): 130 mg/kg bw/day [1]
LOAEL (rabbit): 260 mg/kg bw/day [1]

Study data: dermal
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Genetic toxicity

Study results
Study data: in vitro
  • 48 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 2
Supporting study 4
Weight of evidence 5
Other 1 36
Data waiving
no waivers
Study data: in vivo
  • 28 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study
Supporting study 2
Weight of evidence 4
Other 22
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Carcinogenicity

Study results
  • 7 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 2
Supporting study 2
Weight of evidence
Other 1 2
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to reproduction

Study results
Study data: reproduction
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
Study data: developmental
  • 8 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 2
Supporting study 2
Weight of evidence
Other 1 3
Data waiving
no waivers
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Neurotoxicity

Study results
  • 8 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 7
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant