Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

  • EC / List name: Maleic anhydride
  • IUPAC name: 2,5-dihydrofuran-2,5-dione
  • Other names
EC / List no.:
203-571-6
CAS no.:
108-31-6
Index number:
607-096-00-9
Molecular formula:
C4H2O3
SMILES:
O=C1OC(=O)C=C1
InChI:
InChI=1S/C4H2O3/c5-3-1-2-4(6)7-3/h1-2H
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
36
Of which contain:
3 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Danger! According to the harmonised classification and labelling (ATP13) approved by the European Union, this substance causes severe skin burns and eye damage, causes damage to organs through prolonged or repeated exposure, is harmful if swallowed, causes serious eye damage, may cause an allergic skin reaction and may cause allergy or asthma symptoms or breathing difficulties if inhaled.

Breakdown of all 2706 C&L notifications submitted to ECHA

Acute Tox. 4 H302 Harmonised Classification
Resp. Sens. 1 H334 Harmonised Classification
Skin Corr. 1B H314 Harmonised Classification
Skin Sens. 1 H317
STOT RE 1 H372 Harmonised Classification
Eye Dam. 1 H318 Harmonised Classification
Skin Sens. 1A H317 Harmonised Classification
STOT RE 2 H373
Skin Sens. 1B H317
Acute Tox. 1 H330
Acute Tox. 3 H311
STOT SE 1 H370
STOT SE 2 H371
Skin Corr. 1A H314
Flam. Liq. 3 H226
https://echa.europa.eu/diss-blank-theme/images/cnl/graph/more.png 0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

At least one notifier has indicated that an impurity or an additive present in the substance impacts the notified classification.

Properties of concern

  • Ss
  • Sr

Regulatory activities

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 123 active registrations under REACH, 1 Joint Submission(s) and 3 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Substance Evaluation:
Substance included in the Community Rolling Action Plan (CoRAP).
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Notification:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

About this substance

This substance is manufactured and/or imported in the European Economic Area in 100 000 - 1 000 000 tonnes per year.

This substance is used by consumers, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is used in the following products: adhesives and sealants, fertilisers, washing & cleaning products and water treatment chemicals.

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use as processing aid.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

This substance is used in the following products: adhesives and sealants, fertilisers, pH regulators and water treatment products, laboratory chemicals, washing & cleaning products and water treatment chemicals.

This substance is used in the following areas: health services, agriculture, forestry and fishing and scientific research and development.

This substance is used in the following activities or processes at workplace: closed batch processing in synthesis or formulation, mixing in open batch processes, transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, batch processing in synthesis or formulation with opportunity for exposure, transfer of substance into small containers, laboratory work and open transfer and processing with minerals/metals at elevated temperature.

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use as processing aid.

This substance is used in the following products: polymers, water treatment chemicals, coating products, fertilisers, textile treatment products and dyes, washing & cleaning products and oil and gas exploration or production products.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed batch processing in synthesis or formulation, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, mixing in open batch processes and transfer of substance into small containers.

Release to the environment of this substance can occur from industrial use: formulation of mixtures.

This substance is used in the following products: polymers and laboratory chemicals. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following areas: health services. This substance is used for the manufacture of: plastic products, rubber products and chemicals.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation and laboratory work.

Release to the environment of this substance can occur from industrial use: as an intermediate step in further manufacturing of another substance (use of intermediates), for thermoplastic manufacture and manufacturing of the substance.

This substance is used in the following activities or processes at workplace: closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, transfer of chemicals at dedicated facilities, laboratory work and batch processing in synthesis or formulation with opportunity for exposure.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance, as an intermediate step in further manufacturing of another substance (use of intermediates) and for thermoplastic manufacture.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: contaminated work clothing should not be allowed out of the workplace; do not breathe the dust, fume, gas, mist, vapours or spray; do not eat, drink or smoke when using this product; wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier; avoid breathing the dust, fume, gas, mist, vapours or spray; in case of inadequate ventilation wear respiratory protection.

Response statements

In case of incident: Wash contaminated clothing before reuse. If skin irritation or a rash occurs: get medical advice/attention. If inhaled: if breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. If on skin (or hair): take off immediately all contaminated clothing. Rinse skin with water or shower. If swallowed: rinse mouth. Do not induce vomiting. If in eyes: rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing. If experiencing respiratory symptoms: call a poison center or doctor/physician. If swallowed: call a poison center or doctor/physician if you feel unwell.

Disposal statements

The substance must be disposed in accordance with local/regional/national/international regulation.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • 3M Belgium BVBA/SPRL, Hermeslaan 7 1831 Diegem Belgium
  • AAKO BV, Arnhemseweg 87 3832 GK Leusden Netherlands
  • Addivant UK Ltd, Tenax Road M17 1WT Manchester United Kingdom
  • AFCONA Additives B.V., Amperestraat 34 1704SN Heerhugowaard Netherlands
  • Afton Chemical S.P.R.L. (Woluwe), Alma Court Lenneke Marelaan, 8 B-1932 St-Stevens-Woluwe Belgium
  • Akzo Nobel Surface Chemistry AB, Stenunge Allé 3 - S-44485 Stenungsund - Sweden
  • ALBACHEM SRL, Via Timavo, 200 20099 Sesto San Giovanni Italy
  • ARCHROMA IBÉRICA, S.L., ZAL-Prat c/Cal Coracero, 46-56 08820 El Prat de Llobregat Spain
  • ARKEMA FRANCE, 420 rue d'Estienne d'Orves 92700 COLOMBES France
  • ARLANXEO Brasil S.A., Chempark 51369 Leverkusen NRW Germany
  • Ashland Services BV (0311), Marten Meesweg 8-10 3068 AV Rotterdam Netherlands
  • Ashland Services BV (OR2), Marten Meesweg 8-10 3068 AV Rotterdam Netherlands
  • Baker Hughes Ltd, The Ark, 201 Talgarth Road Hammersmith W6 8BJ London United Kingdom
  • BASF Performance Products France SA, 49, Avenue Georges Pompidou 92593 Levallois-Perret Cedex France
  • BASF Schwarzheide GmbH, Schipkauer Str. 1 01987 Schwarzheide Brandenburg Germany
  • BASF SE, Carl-Bosch-Str. 38 67056 Ludwigshafen am Rhein Rheinland-Pfalz Germany
  • BCS Only Representative Services Ltd, Pembroke House 30 Upper Pembroke Street Dublin 2 Dublin Ireland
  • Beiersdorf Customer Supply GmbH, Unnastrasse 48 20253 Hamburg Germany
  • BENS CONSULTING, kemijsko svetovanje, d.o.o., Bakovniška 7 SI1241 Kamnik Slovenia
  • BSM-OR-polymers-Equistar, Delftseplein 27E 3013 AA Rotterdam Netherlands
  • C.S.B. GmbH, Düsseldorfer Strasse 113 47809 Krefeld Germany
  • Cargill B.V., Evert van de Beekstraat 378 1118 CZ Amsterdam Schiphol North Holland Netherlands
  • CCD (Germany) GmbH, Graf-Adolf-Strasse 68 40210 Düsseldorf Germany
  • CCI Manufacturing Germany GmbH, Borsigstr. 12 41541 Dormagen Germany
  • Celanese Europe BV, The New Atrium Strawinskylaan 3105 1077 ZX Amsterdam Netherlands
  • Charles River Laboratories Den Bosch B.V. OR69, Hambakenwetering 7 5231DD 's-Hertogenbosch Netherlands
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Room 002, Regus Harcourt Centre D02 HW77 D02 Dublin Ireland
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Room 002, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Room 002, Regus Harcourt Centre HW77 D02 Dublin Ireland
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • Chemours Netherlands B.V., Baanhoekweg 22 3313 LA Dordrecht Netherlands
  • Chevron Oronite SA - OR - CVX Japan Ltd, Le Corosa 1, rue Eugène et Armand Peugeot CS10022 92508 Rueil-Malmaison Cedex France
  • Chevron Oronite SA - OR - CVX Oronite Cy LLC, Le Corosa 1, rue Eugène et Armand Peugeot CS10022 92508 Rueil-Malmaison Cedex France
  • Chevron Oronite SA M/I, Le Corosa 1, rue Eugène et Armand Peugeot CS10022 92508 Rueil-Malmaison Cedex France
  • Clariant Oil Services Scandinavia AS, PB 6054 5892 Bergen Norway
  • Clariant Oil Services UK Ltd, Howe Moss Place Kirkhill Industrial Estate AB21 0GS Dyce Aberdeen United Kingdom
  • COMPANÍA ESPAÑOLA DE PETRÓLEOS, S.A.U. (CEPSA), Torre Cepsa, Paseo de la Castellana 259A 28046 Madrid Spain
  • ConvaTec Ltd, GDC First Avenue Deeside Industrial Park CH5 2NU Deeside Flintshire United Kingdom
  • CRAY VALLEY SA OR8, 2 Place Jean Millier 92400 Courbevoie France
  • Dow Belgium B.V.B.A., Sneeuwbeslaan 20, bus 10 2610 Wilrijik Belgium Belgium
  • DOW BENELUX B.V., Postbus 48 4530 AA Terneuzen Netherlands
  • DOW BENELUX B.V. OR-10, Postbus 48 4530 AA Terneuzen Netherlands
  • DOW DEUTSCHLAND ANLAGENGESELLSCHAFT mbH, Am Kronberger Hang 4 D-65824 Schwalbach Germany
  • DOW ITALIA S.R.L., Via F. Albani 65 20148 Milano Italy
  • Eastman Chemical B.V., Watermanweg 70 3067 GG Rotterdam Netherlands
  • Elementis UK Ltd., Caroline House 55 - 57 High Holborn WC1V 6DX London United Kingdom
  • Envigo Research Limited 189, Shardlow Business Park London Road DE72 2GD Shardlow Derbyshire United Kingdom
  • Enviresearch Portugal Unipessoal Limitada, Rua Fernando Pessoa, 319 2 C Sassoeiros 2775-515 Carcavelos Lisbon Portugal
  • ESIM Chemicals GmbH, St.-Peter-Strasse 25 4020 Linz Austria
  • Evonik Performance Materials GmbH, Rellinghauser Strasse 1-11 45128 Essen Germany
  • Evonik Performance Materials GmbH - OR R1, Kirschenallee 64293 Darmstadt Germany
  • Evonik Resource Efficiency GmbH, Rellinghauser Strasse 1-11 45128 Essen Germany
  • Harke Services GmbH - OR1, Xantener Str.1 45479 Mülheim an der Ruhr Germany
  • Helm AG, Nordkanalstraße 28 20097 Hamburg Germany
  • Honeywell Belgium N.V., Interleuvenlaan 15i Haasrode Research Park B-3001 Heverlee Belgium
  • Honeywell Belgium NV OR-1000, Gaston Geenslaan 14 - 2nd Floor Arenberg Wetenschapspark B-3001 Heverlee Belgium
  • Huntsman (Europe) BVBA - OR1, Everslaan 45 B-3078 Everberg Belgium
  • Huntsman (Europe) BVBA - OR2, Everslaan 45 B-3078 Everberg Belgium
  • Infineum Italia, Strada di Scorrimento 2 17047 Vado Ligure (SV) Italy
  • Infineum Italia, Strada di Scorrimento 2 17047 Vado Ligure (SV) Italy
  • Infineum Italia, Strada di Scorrimento 2 17047 Vado Ligure (SV) Italy
  • Innospec Limited (OR1), Innospec Manufacturing Park Oil Sites Road CH65 4EY Ellesmere Port Cheshire United Kingdom
  • Intertek Deutschland GmbH, Stangenstrasse 1 D-70771 Leinfelden-Echterdingen Germany
  • Intertek Deutschland GmbH 6, Stangenstrasse 1 70771 Leinfelden-Echterdingen Germany
  • Intertek deutschland GmbH TECH, Stangenstr. 1 70771 Leinfelden-Echterdingen Germany
  • ITS Testing Services (UK) Ltd 16, Caleb Brett House 734 London Road RM20 3NL West Thurrock, Grays Essex United Kingdom
  • Kao Chemicals Europe, S.L. (2), Puig dels Tudons, 10 08210 Barbera del Valles Barcelona Spain
  • Kemira Oyj, Energiakatu 4 P.O.Box 330 FI-00101 HELSINKI Finland
  • King Industries International, Science Park 402 1098 XH Amsterdam Amsterdam Netherlands
  • Knoell NL-OR-042, Agro Business Park 75 6708 PV Wageningen Netherlands
  • Kraton Chemical AB OR1, Massvagen 15 P.O. Box 66 SE-820 22 Sandarne Sweden
  • KTR Europe GmbH, Mergenthalerallee 77 65760 Eschborn Germany
  • Kuraray Europe GmbH (OR1), Philipp-Reis-Str. 4 65795 Hattersheim Germany
  • Lanxess Corp OR, Chempark 51369 Leverkusen NRW Germany
  • Lanxess Deutschland GmbH, Kennedyplatz 1 50569 Köln Germany
  • Lapiz Europe Limited as Only Representative for Optimistic Organic SDN.BHD, No : 204-226 Talbot House, Imperial Drive Rayners Lane, HA2 7HH Harrow Middlesex United Kingdom
  • Lawter BVBA, Haven 1520 Ketenislaan 1 B-9130 Kallo East Flanders Belgium
  • Lubrizol Deutschland GmbH, Max-Planck-Strasse 6 27721 RITTERHUDE Germany
  • Lubrizol Europe Coordination Center BVBA 02 , Chaussee De Wavre 1945 Brussels Belgium
  • Lubrizol Europe Coordination Center BVBA 05, Chaussee De Wavre 1945 Brussels Belgium
  • Lubrizol Europe Coordination Center BVBA 06, Chaussee De Wavre 1945 Brussels Belgium
  • Lubrizol Europe Coordination Center BVBA 07, Chaussee De Wavre 1945 Brussels Belgium
  • Lubrizol Europe Coordination Center BVBA 09, Chaussee De Wavre 1945 Brussels Belgium
  • Lubrizol Europe Coordination Center BVBA 12, Chaussee De Wavre 1945 Brussels Belgium
  • Lubrizol France SAS, 25 Quai de France 76100 ROUEN France
  • Lubrizol Limited, The Knowle, Nether Lane Hazelwwod DE56 4AN Derby Derbyshire United Kingdom
  • Lubrizol Limited 01, The Knowle, Nether Lane Hazelwwod DE56 4AN Derby Derbyshire United Kingdom
  • Lubrizol Limited 15, The Knowle,Nether Lane DE56 4AN Derby Derbyshire United Kingdom
  • Lubrizol Limited 16, The Knowle,Nether Lane DE56 4AN Derby Derbyshire United Kingdom
  • MHM Holding GmbH, Feldkirchener Straße 15 D-85551 Kirchheim Germany
  • Michelman International Belgium SPRL OR, Zoning Industriel B-6790 Aubange Belgium
  • MOL Hungarian Oil and Gas Public Limited Company, Oktober huszonharmadika 18 1117 Budapest Hungary
  • MonoSol AF LTD, Oak Drive Hartlebury Trading Estate DY 10 4JB Hartlebury Worcestershire United Kingdom
  • Nalco Limited, P.O. Box 11, Winnington Avenue, CW8 4DX Northwich, Cheshire United Kingdom
  • NetSun EU B.V.( Shandong Taihe Water Treatment Technologies Co., Ltd.), Blaak 40, Fifth Floor 3011 TA Rotterdam Netherlands
  • Nippon Gohsei UK Ltd, Soarnol House Saltend HU12 8DS Hull East Yorkshire United Kingdom
  • Penpet Petrochemical Trading GmbH, Merkurring 105 22143 Hamburg Germany
  • Performance Materials Ibérica, S.L.U., Av. Diagonal Num. 571 08029 Barcelona Spain
  • Performance Specialty Products Ibérica, S.L.U., Valle de Tamón - Nubledo 33469 Tamón - Carreño Asturias Spain
  • POLYNT S.p.A., via Enrico Fermi, 51 I-24020 Scanzorosciate BG Italy
  • PPG Europe B.V. - OR3, Amsterdamseweg 14 1422 AD Uithoorn Netherlands
  • PPG Industries Italia Srl Società soggetta a direzione e coordinamento da parte di PPG Industries Inc., Via Serra, 1 15028 Quattordio Italy
  • REACH24H CONSULTING GROUP, Paramount Court, Corrig Road, Sandyford Dublin 18 Dublin Ireland
  • REACHLaw Ltd., Vänrikinkuja 3 JK 21 02600 Espoo Finland
  • RHODIA OPERATIONS - 17, 40 rue de la Haie Coq 93306 Aubervilliers France
  • RHODIA OPERATIONS - 2, 40 rue de la Haie Coq 93306 Aubervilliers France
  • Ruse Chemicals, 133, Bulgaria blvd. 7000 Rousse Bulgaria
  • Sasol-Huntsman GmbH & Co. KG, Roemerstr. 733 47443 Moers Germany
  • SIGMA-ALDRICH CHEMIE GMBH, Riedstrasse 2 89555 Steinheim Germany
  • SNF SA, ZAC de Milieux 42163 Andrézieux France
  • Solenis Netherlands B.V., Fascinatio Boulevard 522 2909 VA CAPELLE A/D IJSSEL Netherlands
  • SOLVAY SOLUTIONS NEDERLAND B.V., ENERGIEWEG 1 4791RN Klundert Netherlands
  • Stafford-Miller (Ireland) Limited, Clocherane Youghal Road _ Dungarvan Waterford Ireland
  • STEPAN EUROPE SA, Chemin JONGKIND 38340 VOREPPE France
  • SUEZ Water Technologies & Solutions Belgium BVBA, Toekomstlaan 54 2200 Herentals Belgium
  • SUEZ WTS France, Tour CB21 16 Place de l’Iris 92040 Paris La Défense France
  • TramacoGmbH, Lise-Meitner-Allee 8 25411 Tornesch Germany
  • TÜV SÜD Iberia S.A.U. (003), Ronda Can Fatjó 13 08290 Cerdanyola del Vallès Barcelona Spain
  • TÜV SÜD Iberia S.A.U. (051), Ronda Can Fatjó 13 08290 Cerdanyola del Vallès Barcelona Spain
  • Vertellus Specialties UK Ltd, Seal Sands Road Seal Sands TS2 1UB Middlesbrough Cleveland United Kingdom
  • [Confidential], [Confidential]
  • Grupa Azoty Zakłady Azotowe Kędzierzyn Spółka Akcyjna, skr. poczt. 163 ul. Mostowa 30A 47-220 Kędzierzyn-Kożle Poland
  • Huntsman (Europe) BVBA - OR4, Everslaan 45 B-3078 Everberg Belgium
  • Intertek Deutschland GmbH, Stangenstrasse 1 D-70771 Leinfelden-Echterdingen Germany

Other names

  • -
  • 2,5-dihydrofuran-2,5-dione
  • 2,5-Furandione
  • 203-571-6
  • butenedioic anhydride, toxilic anhydride, 2,5-dioxofuran
  • Cis-butenedioic anhydride
  • fruan-2,5-dione
  • Furan - 2,5 - dione
  • Furan-2,5 dione
  • furan-2,5-dion
  • Furan-2,5-dione
  • Furan-2.5-dione
  • Furane-2,5-dione
  • Maleic Abhydride
  • MALEIC ANHYDRIDE
  • Maleinsäureanhydrid
  • Maleic anhydride
  • 2,5 Furandione
  • 2,5-Diossi-diidrofurano
  • 2,5-Dioxo-dihydrofuran
  • 2,5-Furandion
  • 2,5-Furandion, MSA, cis-Butensäureanhydrid
  • 2,5-FURANDIONE
  • 2,5-Furandione (9CI)
  • 2,5-Furandione (9Cl)
  • 2,5-Furandione, Maleinsäureanhydrid
  • 2,5-Furanedione
  • 2,5-FURANEDIONE. TOXILIC ANHYDRIDE.CIS-BUTENEDIOIC ANHYDRIDE
  • 2-5 Furandiona
  • 2-Butendicarbonsaeureanhydrid
  • 2.5 furandion
  • Anhydride maleique; cis-butenedioic anhydride
  • Anidride Cis-Butendioica
  • Anidride dell'acido cis-etilendicarbossilico
  • Anidride dell'acido maleico
  • Anidride Maleica
  • Anidride maleica solida
  • Anidride tossilica
  • Aropol
  • bezwodnik maleinowy
  • BM 10
  • cis- Ethendicarboxylic Anhydride
  • cis-Butanedioic anhydride
  • cis-butendioc anhydride
  • CIS-BUTENEDIOIC ANHYDRIDE
  • cis-Butenedioic anhydrides Maleic anhydride
  • cis-Butensäureanhydrid
  • cis-Butensäureanhydrid, MSA
  • cis-Ethendicarbonsaeureanhydrid
  • Crystal Man
  • Dihydro-2,5-dioxofuran
  • EPS
  • Ethylendicarbonsaeureanhydrid
  • furan-2,5-dione
  • furandione
  • MA
  • MALEIC ACID ANHYDRIDE
  • Maleic acid anhydride, cis-Butenedioic anhydride.
  • Maleic Anhydride
  • Maleic anhydride (8CI)
  • maleic anhydride (8Cl)
  • Maleic anhydride; cis-butenedioc anhydride; maleic acid anhydride
  • Maleicanhydride
  • Maleinsaeureanhydrid
  • Maleinsavanhidrid
  • Maleinsäureanhydrid
  • MAN
  • Maxguard
  • MSA
  • Nourymix MA 901
  • Optipak 200
  • Polybond 2006
  • Polybond 2021
  • Polybond 2021P
  • Polybond 3001
  • Polybond 3002
  • Polybond 3005
  • Polybond 3009
  • TOXILIC ANHYDRIDE

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 2 studies submitted
  • 2 studies processed
C Physical state at 20°C and 1013 hPa
Solid (100%) [2]
C Form
Other (100%) [2]
C Odour
Other (100%) [1]
C Substance type
Organic (100%) [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Physical state at 20°C and 1013 hPa
Solid (100%)

Melting/freezing point

Study results
  • 7 studies submitted
  • 2 studies processed
R Melting / freezing point
51.2 - 58 °C [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 4
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Melting / freezing point at 101 325 Pa
53 °C

Boiling point

Study results
  • 5 studies submitted
  • 2 studies processed
R Boiling point
185 - 200.1 °C @ 101 - 101.37 kPa [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 2
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Boiling point at 101 325 Pa
200 °C

Density

Study results
  • 5 studies submitted
  • 3 studies processed
R Density
1.3 - 1.48 g/cm³ @ 20 - 60 °C [2]
R Relative density
1.48 @ 20 °C [2]

Type of Study provided
Studies with data
Key study 1
Supporting study 1 1
Weight of evidence 2
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Relative density at 20°C
1.48 - 1 480

Vapour pressure

Study results
  • 7 studies submitted
  • 2 studies processed
R Vapour pressure
15.1 - 108 Pa @ 22 - 40 °C [6]

Type of Study provided
Studies with data
Key study 1 1
Supporting study 2 1 1
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Vapour pressure
15.1 Pa @ 22 °C

Partition coefficient

Study results
  • 5 studies submitted
  • 2 studies processed
R Log Pow
-2.78 - -2.36 @ 19.8 °C and pH 4 - 9 [4]

Type of Study provided
Studies with data
Key study 2
Supporting study 2 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Log Kow (Log Pow)
-2.61 @ 20 °C

Water solubility

Study results
  • 3 studies submitted
  • 1 study processed
R Water solubility (mass/vol.)
402 - 418 g/L @ 20 °C and pH 4 - 9 [3]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
R Summaries
  • 1 summary submitted
  • 1 summary processed
Water solubility
400 g/L @ 20 °C

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Flash point

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 2
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Auto flammability

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 2
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Flammability

Study results
  • 8 studies submitted
  • 1 study processed
C Interpretation of results
Non flammable (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 2 1
Weight of evidence 1
Other 1
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Flammability
Non flammable (100%)

Explosiveness

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
C Summaries
  • 1 summary submitted
  • 1 summary processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
C Summaries
  • 1 summary submitted
  • 1 summary processed
Oxidising
No (100%)

Oxidation reduction potential

Data not provided by the registrant

pH

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers

No summary exists for this scientific endpoint

Dissociation constant

Study results
  • 2 studies submitted
  • 1 study processed
C Dissociating properties
Yes (100%) [1]
R Dissociation constant
0 - 0.011 @ 25 °C [2]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
R Summaries
  • 1 summary submitted
  • 1 summary processed
pKa at 20 °C
0

Viscosity

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 5 studies submitted
  • 1 study processed
R Dissipation half life (DT50)
8.5 h [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 3 1
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Hydrolysis

Study results
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in water

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Phototransformation in soil

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Biodegradation in water - screening tests

Study results
  • 9 studies submitted
  • 2 studies processed
C Interpretation of results
Readily biodegradable (100%) [2]

Type of Study provided
Studies with data
Key study 1 1
Supporting study 3 1
Weight of evidence
Other 3
Data waiving
no waivers
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Biodegradation in water
Readily biodegradable (100%)

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in soil

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: aquatic / sediment

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: terrestrial

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Adsorption/desorption

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
R Summaries
  • 1 summary submitted
  • 1 summary processed
Koc at 20°C
42

Henrys law constant (H)

Study results
  • 2 studies submitted
  • 1 study processed
R H - (pressure) m³/mol
0 Pa m³/mol @ 25 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Henry's law constant
0 Pa.m³.mol-1 @ 25 °C

Distribution modelling

Study results
  • 2 studies submitted
  • 1 study processed
% Distribution in Media:
R Air 0 % [1]
R Water 100 % [1]
R Soil 0 % [1]
R Sediment 0 % [1]
R Suspended sediment 0 % [1]
R Biota 0 % [1]
R Aerosol 0 % [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers

No summary exists for this scientific endpoint

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 2 summaries submitted
  • 2 summaries processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 75 - 100 µg/L (2)
Intermittent releases (freshwater) 428.1 - 750 µg/L (2)
Marine water 7.5 - 10 µg/L (2)
Intermittent releases (marine water) -
Sewage treatment plant (STP) 4.46 - 44.6 mg/L (2)
Sediment (freshwater) 60 - 334 µg/kg sediment dw (2)
Sediment (marine water) 6 - 33.4 µg/kg sediment dw (2)
Hazard for Air
Air No hazard identified (1)
Hazard for Terrestrial Organism
Soil 10 - 41.5 µg/kg soil dw (2)
Hazard for Predators
Secondary poisoning 6.67 mg/kg food (1)

Short–term toxicity to fish

Study results
  • 16 studies submitted
  • 4 studies processed
P/RResults
LC50 (4 days) 75 mg/L [4]
LC50 (48 h) 75 mg/L [2]
LC50 (24 h) 75 mg/L [2]

Type of Study provided
Studies with data
Key study 4
Supporting study 5
Weight of evidence
Other 7
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
LC50 for freshwater fish
75 mg/L

Long–term toxicity to fish

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Short–term toxicity to aquatic invertebrates

Study results
  • 7 studies submitted
  • 2 studies processed
P/RResults
EC50 (48 h) 42.81 - 330 mg/L [3]
EC50 (24 h) 340 mg/L [1]
NOEC (48 h) 17.5 mg/L [1]
LOEC (48 h) 30.63 mg/L [1]

Type of Study provided
Studies with data
Key study 1 1
Supporting study 3
Weight of evidence
Other 2
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
EC50 / LC50 for freshwater invertebrates
42.81 - 330 mg/L

Long–term toxicity to aquatic invertebrates

Study results
  • 3 studies submitted
  • 1 study processed
P/RResults
NOEC (21 days) 10 mg/L [1]
EC50 (21 days) 77 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC10 / LC10 or NOEC for freshwater invertebrates
10 mg/L

Toxicity to aquatic algae and cyanobacteria

Study results
  • 6 studies submitted
  • 2 studies processed
P/RResults
EC50 (72 h) 74.35 - 150 mg/L [3]
NOEC (72 h) 150 mg/L [2]
EC10 (72 h) 11.8 mg/L [1]
EC20 (72 h) 22.2 mg/L [1]

Type of Study provided
Studies with data
Key study 1 1
Supporting study 1
Weight of evidence 2
Other 1
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
EC50 for freshwater algae
74.32 - 150 mg/L
EC10 or NOEC for freshwater algae
11.8 - 150 mg/L

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 11 studies submitted
  • 4 studies processed
P/RResults
EC50 (15 min) 12.5 mg/L [2]
EC10 (18 h) 44.6 mg/L [2]

Type of Study provided
Studies with data
Key study 1
Supporting study 1 1
Weight of evidence 4
Other 4
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
EC10 or NOEC for microorganisms
44.6 mg/L

Sediment toxicity

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons. 1
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons. 1
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial arthropods

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons. 1
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial plants

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons. 1
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to soil microorganisms

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons. 1
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to birds

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 190 µg/m³ repeated dose toxicity
Acute /short term: (DNEL) 800 µg/m³ irritation (respiratory tract)
Local Effects
Long-term: (DNEL) 320 µg/m³ repeated dose toxicity
Acute /short term: - -
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 200 µg/kg bw/day repeated dose toxicity
Acute /short term: (DNEL) 200 µg/kg bw/day repeated dose toxicity
Local Effects
Long-term: High hazard (no threshold derived)
Acute /short term: High hazard (no threshold derived)
EYE Exposure
High hazard (no threshold derived)
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 50 µg/m³ repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: (DNEL) 80 µg/m³ repeated dose toxicity
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 100 µg/kg bw/day repeated dose toxicity
Acute /short term: (DNEL) 100 µg/kg bw/day repeated dose toxicity
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 60 µg/kg bw/day effect on fertility
Acute /short term: (DNEL) 100 µg/kg bw/day repeated dose toxicity
EYE Exposure
No hazard identified

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 1
Supporting study 1
Weight of evidence 1
Other
Data waiving
no waivers
Study data: dermal absorption
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Bioaccumulation potential:
No bioaccumulation potential

Acute toxicity

Study results
oral
  • 12 studies submitted
  • 1 study processed
P/RResults
LD50 1 090 mg/kg bw (rat) [1]

Type of Study provided
oral
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 8 1
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
inhalation
  • 3 studies submitted
  • 1 study processed
P/RResults
LC50 (60 min) 4.35 mg/L air (rat) [1]
M/CInterpretations of results
Relatively harmless [1]

inhalation
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
dermal
  • 6 studies submitted
  • 1 study processed
P/RResults
LD50 2 620 mg/kg bw (rabbit) [1]
M/CInterpretations of results
Relatively harmless [1]

dermal
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 3
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Oral route:
Adverse effect observed LD50 1 090 mg/kg bw
Inhalation route:
Adverse effect observed LC50 4.35 mg/m³
Dermal route:
Adverse effect observed LD50 2 620 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 8 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 4
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Study data: eye
  • 9 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other 4
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Skin
Adverse effect observed (corrosive)
Eye
Adverse effect observed (irritating)
Respiratory
Adverse effect observed (irritating)

Sensitisation

Study results
Study data: skin
  • 8 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study 2
Weight of evidence 1
Other 3
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Study data: respiratory
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Skin sensitisation
Adverse effect observed (sensitising)
Respiratory sensitisation
Adverse effect observed (sensitising)

Repeated dose toxicity

Study results
Study data: oral
  • 9 studies submitted
  • 3 studies processed
P/RResults
NOAEL (rat): 10 mg/kg bw/day [1]
NOAEL (dog): 60 mg/kg bw/day [1]
LOAEL (rat): 100 - 250 mg/kg bw/day [2]
NOEL (rat): 40 - 100 mg/kg bw/day [2]

Type of Study provided
Study data: oral
Studies with data
Key study 4
Supporting study 3 1
Weight of evidence
Other 1
Data waiving
no waivers
Study data: inhalation
  • 8 studies submitted
  • 7 studies processed
P/RResults
NOAEC (rat): 3.3 mg/m³ air [2]
NOAEC (hamster): 9.8 mg/m³ air [2]
NOAEC (monkey): 9.8 mg/m³ air [3]
LOAEC (rat): 1.1 - 10 mg/m³ air [4]
LOAEC (hamster): 3.3 mg/m³ air [1]

Study data: inhalation
Studies with data
Key study 7
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Inhalation route - local effects:
Adverse effect observed LOAEC 10 mg/m³ (subacute, rat)

Genetic toxicity

Study results
Study data: in vitro
  • 10 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 1 1
Supporting study 4
Weight of evidence 4
Other
Data waiving
no waivers
Study data: in vivo
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 1
Supporting study 1
Weight of evidence 1
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Carcinogenicity

Study results
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other 1
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Oral route:
No adverse effect observed NOAEL 100 mg/kg bw/day (chronic, rat)

Toxicity to reproduction

Study results
Study data: reproduction
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: developmental
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant