Brief Profile

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Please be aware that the REACH registration parts of this Brief Profile are no longer maintained; they remain frozen as of 19th May 2023. All other data parts (substance identity, C&L, key regulatory lists etc. are up to date).

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
203-571-6
CAS no.:
108-31-6
Index number:
607-096-00-9
Molecular formula:
C4H2O3
SMILES:
O=C1OC(=O)C=C1
InChI:
InChI=1S/C4H2O3/c5-3-1-2-4(6)7-3/h1-2H
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
46
Of which contain:
3 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Danger! According to the harmonised classification and labelling (ATP13) approved by the European Union, this substance causes severe skin burns and eye damage, causes damage to organs through prolonged or repeated exposure, is harmful if swallowed, causes serious eye damage, may cause an allergic skin reaction and may cause allergy or asthma symptoms or breathing difficulties if inhaled.

Additionally, the classification provided by companies to ECHA in REACH registrations identifies that this substance is harmful in contact with skin.

Breakdown of all 4555 C&L notifications submitted to ECHA

Acute Tox. 4 H302 Harmonised Classification
Resp. Sens. 1 H334 Harmonised Classification
Skin Corr. 1B H314 Harmonised Classification
Skin Sens. 1 H317
Eye Dam. 1 H318 Harmonised Classification
STOT RE 1 H372 Harmonised Classification
Skin Sens. 1A H317 Harmonised Classification
STOT RE 2 H373
Skin Sens. 1B H317
STOT SE 1 H370
Acute Tox. 3 H311
Acute Tox. 1 H330
STOT SE 2 H371
Flam. Liq. 3 H226
Not Classified
https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/more.png 0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

At least one notifier has indicated that an impurity or an additive present in the substance impacts the notified classification.

Properties of concern

  • Ss
Officially recognised in the EU as Skin sensitising ( Harmonised C&L).
  • Ss
There is no overall agreement among data submitters, but a minority indicate they consider this substance as Skin sensitising (2.23% of REACH registrations).
  • Sr
Officially recognised in the EU as Respiratory sensitising ( Harmonised C&L).
  • Sr
There is no overall agreement among data submitters, but a minority indicate they consider this substance as Respiratory sensitising (2.23% of REACH registrations).

Nanomaterial form

Substance is known to be on the EEA market in nanomaterial form, as listed in the EUON Nanomaterials in the EU market list.

Regulatory context

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 155 active registrations under REACH, 2 Joint Submission(s) and 3 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Substance Evaluation:
Substance included in the Community Rolling Action Plan (CoRAP).
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Persistent Organic Pollutants Regulation (POPs)

List of substances subject to the POPs Regulation:
List of substances proposed as POPs:

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Seveso Annex I:
Notified C&L:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:
Nanomaterials in the EU Market

About this substance

This substance is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 100 000 tonnes per annum.

This substance is used by consumers, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is used in the following products: adhesives and sealants, fertilisers, lubricants and greases, washing & cleaning products and water treatment chemicals.

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use as processing aid, indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

This substance is used in the following products: adhesives and sealants, fertilisers, heat transfer fluids, hydraulic fluids, pH regulators and water treatment products, laboratory chemicals, lubricants and greases, washing & cleaning products and water treatment chemicals.

This substance is used in the following areas: health services, agriculture, forestry and fishing and scientific research and development.

This substance is used in the following activities or processes at workplace: closed processes with no likelihood of exposure, closed batch processing in synthesis or formulation, mixing in open batch processes and transfer of chemicals.

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use as processing aid, indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).

This substance is used in the following products: polymers, water treatment chemicals, coating products, textile treatment products and dyes and oil and gas exploration or production products.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed batch processing in synthesis or formulation, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure and mixing in open batch processes.

Release to the environment of this substance can occur from industrial use: formulation of mixtures.

This substance is used in the following products: laboratory chemicals and polymers. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following areas: scientific research and development. This substance is used for the manufacture of: chemicals, plastic products and rubber products.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed batch processing in synthesis or formulation, closed, continuous processes with occasional controlled exposure and laboratory work.

Release to the environment of this substance can occur from industrial use: as an intermediate step in further manufacturing of another substance (use of intermediates) and for thermoplastic manufacture.

This substance is used in the following activities or processes at workplace: closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, transfer of chemicals at dedicated facilities, laboratory work and batch processing in synthesis or formulation with opportunity for exposure.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance, as an intermediate step in further manufacturing of another substance (use of intermediates) and for thermoplastic manufacture.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: in case of inadequate ventilation wear respiratory protection; contaminated work clothing should not be allowed out of the workplace; do not breathe the dust, fume, gas, mist, vapours or spray; avoid breathing the dust, fume, gas, mist, vapours or spray; do not eat, drink or smoke when using this product; wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier.

Response statements

In case of incident: If swallowed: call a poison center or doctor/physician if you feel unwell. If on skin (or hair): take off immediately all contaminated clothing. Rinse skin with water or shower. If swallowed: rinse mouth. Do not induce vomiting. Wash contaminated clothing before reuse. If inhaled: if breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. If experiencing respiratory symptoms: call a poison center or doctor/physician. If skin irritation or a rash occurs: get medical advice/attention. If in eyes: rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing.

Disposal statements

The substance must be disposed in accordance with local/regional/national/international regulation.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • 3M Belgium BVBA/SPRL (OR1), Hermeslaan 7 1831 Diegem Belgium
  • AAKO BV, Arnhemseweg 87 3832 GK Leusden Netherlands
  • AdvanSix Resins & Chemicals (Ireland) Limited, 13-18 City Quay D02 ED70 Dublin Ireland Ireland
  • AFCONA Additives B.V., Amperestraat 34 1704SN Heerhugowaard Netherlands
  • Afton Chemical S.R.L. (Woluwe), Alma Court Lenneke Marelaan, 8 B-1932 St-Stevens-Woluwe Belgium
  • ALBACHEM SRL, Via Timavo, 200 20099 Sesto San Giovanni Italy
  • AOC Nederland B.V., Nieuw Amsterdamseweg 31A 7764 AN Zandpol Netherlands
  • AOC Nederland B.V. OR2, Nieuw Amsterdamseweg 31 7764 AN Zandpol Netherlands
  • Archroma France, SAS, Rue du Flottage 60350 Trosly-Breuil France
  • ARCHROMA IBÉRICA, S.L., ZAL-Prat c/Cal Coracero, 46-56 08820 El Prat de Llobregat Spain
  • ARLANXEO Netherlands B.V. (OR for Brazil), Urmonderbaan 24 6167 RD Geleen Netherlands
  • Ashland Services BV (0311), Noordweg 9 3336 LH Zwijndrecht Netherlands
  • Ashland Services BV (OR2), Noordweg 9 3336 LH Zwijndrecht Netherlands
  • BASF Espanola S.L., Calle Can Ràbia, n. 3-5 8017 Barcelona Spain
  • BASF Schwarzheide GmbH, Schipkauer Str. 1 01987 Schwarzheide Brandenburg Germany
  • BASF SE, Carl-Bosch-Str. 38 67056 Ludwigshafen am Rhein Rheinland-Pfalz Germany
  • BCS Only Representative Services Ltd, Pembroke House 30 Upper Pembroke Street Dublin 2 Dublin Ireland
  • BD&I_31, rue Omer Lepreux 92 1081 bruxelles Belgium
  • Beiersdorf Customer Supply GmbH, Unnastrasse 48 20253 Hamburg Germany
  • BENS CONSULTING, kemijsko svetovanje, d.o.o., Bakovniška 7 1241 Kamnik Slovenia
  • BorsodChem Zrt. - OR, Bolyai ter 1. H-3700 Kazincbarcika Hungary
  • C.S.B. GmbH, Dujardinstr. 5 47829 Krefeld Germany
  • Cargill NV (US-OR), Bedrijvenlaan 7-9 2800 Mechelen Belgium
  • CCD (Germany) GmbH, Berliner Allee 55 40212 Düsseldorf Germany
  • CCI Manufacturing Germany GmbH, Borsigstr. 12 41541 Dormagen Germany
  • Celanese Europe BV, The New Atrium Strawinskylaan 3105 1077 ZX Amsterdam Netherlands
  • ChampionX Europe B.V., Oude Rhijnhofweg 17 NL-2342BB Oegstgeest Oegstgeest Netherlands
  • Charles River Laboratories Den Bosch B.V. OR69, Hambakenwetering 7 5231DD 's-Hertogenbosch Netherlands
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Room 002, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Room 002, Regus Harcourt Centre D02 HW77 D02 Dublin Ireland
  • Chemical Inspection & Regulation Service Limited, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED (Shandong Taihe Water Treatment Technologies Co., Ltd.), Regus Harcourt Centre D02 HW77 Dublin Ireland
  • Cheminova A/S, Thyborønvej 78 DK-7673 Harboøre Denmark
  • Chevron Oronite SA - OR - CVX Japan Ltd, Le Corosa 1, rue Eugène et Armand Peugeot CS10022 92508 Rueil-Malmaison Cedex France
  • Chevron Oronite SA - OR - CVX Oronite Cy LLC, Le Corosa 1, rue Eugène et Armand Peugeot CS10022 92508 Rueil-Malmaison Cedex France
  • Chevron Oronite SA M/I, Le Corosa 1, rue Eugène et Armand Peugeot CS10022 92508 Rueil-Malmaison Cedex France
  • Clariant Oil Services Scandinavia AS, PB 6054 5892 Bergen Norway
  • Clariant Produkte (Deutschland) GmbH, August-Laubenheimer-Straße 1 Global Product Stewardship 65929 Frankfurt am Main Germany
  • Clariant SE - GB04, August-Laubenheimer-Strasse 1 65929 Frankfurt am Main Germany
  • Connect Chemicals Italia S.r.l., Via Torri Bianche, 9 20871 Vimercate (MB) Italy
  • ConvaTec (Unomedical) Slovakia, Priemyselný park 3 071 01 Michalovce Slovakia
  • CRAY VALLEY SA OR8, 2 Place Jean Millier 92400 Courbevoie France
  • CS Regulatory Ireland Ltd. in its legal capacity as Only Representative of LANXESS Corporation, Alexandra House The Sweepstakes D04 C7H2 Dublin Ballsbridge Ireland
  • Dow Belgium B.V.B.A., Grotesteenweg 214 B-2600 Antwerpen (Berchem) Belgium
  • DOW BENELUX B.V., Postbus 48 4530 AA Terneuzen Netherlands
  • DOW BENELUX B.V. OR-10, Postbus 48 4530 AA Terneuzen Netherlands
  • DOW CHEMICAL IBERICA S.L., Ribera del Loira 4-6 Edificio Iris, 4º Planta 28042 Madrid Spain
  • DOW DEUTSCHLAND ANLAGENGESELLSCHAFT mbH, Buetzflether Sand 2 D-21683 Stade Germany
  • DOW ITALIA S.R.L., Via F. Albani 65 20148 Milano Italy
  • Eastman Chemical B.V., Watermanweg 70 3067 GG Rotterdam Netherlands
  • Elementis Minerals B.V., Kajuitweg 8 1041AR Amsterdam Netherlands
  • Enviresearch Portugal Unipessoal Limitada, Edifício Amoreiras Square, Rua Carlos Alberto da Mota Pinto 17, 3º A 1070 - 313 Lisboa Portugal
  • ERM_GmbH_OR13_KM, Siemenstrasse 9. 63263 Neu Isenburg Hessen Germany
  • Evonik Operations GmbH, Rellinghauser Straße 1-11 45128 Essen Germany
  • Harke Services GmbH - OR1, Xantener Str.1 45479 Mülheim an der Ruhr Germany
  • Helm AG, Nordkanalstraße 28 20097 Hamburg Germany
  • Honeywell Advanced Limited, Riverview House, Harvey's Quay Apartments, Harvey's Quay V94R3DE Limerick Co. Limerick Ireland
  • Honeywell Advanced Limited OR, Riverview House, Harvey's Quay Apartments, Harvey's Quay V94R3DE Limerick Co. Limerick Ireland
  • Huntsman (Europe) BV - OR1, Everslaan 45 B-3078 Everberg Belgium
  • Huntsman (Europe) BV - OR2, Everslaan 45 B-3078 Everberg Belgium
  • HUNTSMAN HOLLAND BV, Merseyweg 10 3197 KG Botlek-Rotterdam Netherlands
  • Huntsman Products GmbH, Roemerstr. 733 47443 Moers Germany
  • Huntsman Textile Effects (Germany) GmbH, Rehlinger Str. 1 D-86462 Langweid a.Lech Germany
  • Infineum Italia, Strada di Scorrimento 2 17047 Vado Ligure (SV) Italy
  • Infineum Italia, Strada di Scorrimento 2 17047 Vado Ligure (SV) Italy
  • Infineum Italia, Strada di Scorrimento 2 17047 Vado Ligure (SV) Italy
  • Innospec Performance Chemicals France SAS (Only Rep 3), Zone Industrielle de Han Sur Meuse BP19 55300 Saint-Mihiel France
  • Intertek Deutschland GmbH 16, Stangenstrasse 1 70771 Leinfelden-Echterdingen Germany
  • Intertek Deutschland GmbH 6, Stangenstrasse 1 70771 Leinfelden-Echterdingen Germany
  • Intertek Deutschland GmbH 60, Intertek Deutschland GmbH Stangenstrasse 1 70771 Leinfelden-Echterdingen Germany
  • Intertek Deutschland GmbH 61, Intertek Deutschland GmbH Stangenstrasse 1 70771 Leinfelden-Echterdingen Germany
  • Intertek deutschland GmbH TECH, Stangenstr. 1 70771 Leinfelden-Echterdingen Germany
  • Jowat SE, Ernst-Hilker-Str. 10 - 14 32758 Detmold NRW Germany
  • Kao Chemicals Europe, S.L. (2), Puig dels Tudons, 10 08210 Barbera del Valles Barcelona Spain
  • Kemira Oyj, Energiakatu 4 P.O.Box 330 FI-00101 HELSINKI Finland
  • King Industries International, Science Park 402 1098 XH Amsterdam Amsterdam Netherlands
  • Kraton Chemical AB OR1, Massvagen 15 P.O. Box 66 SE-820 22 Sandarne Sweden
  • KTR Europe GmbH, Mergenthalerallee 77 65760 Eschborn Germany
  • Kuraray Europe GmbH, Philipp-Reis-Str. 4 65795 Hattersheim Germany
  • Kuraray Europe GmbH (OR1), Philipp-Reis-Str. 4 65795 Hattersheim Germany
  • Labcorp Development SA 172, Parque Empresarial Las Tablas, Edificio 1 Calle Federico Mompou, 5 - 5 Planta 28050 Madrid Spain
  • Lawter Europe, Haven 1520 Ketenislaan 1 B-9130 Kallo East Flanders Belgium
  • Lubrizol Deutschland GmbH, Max-Planck-Strasse 6 27721 RITTERHUDE Germany
  • Lubrizol Europe Coordination Center BVBA 01, Chaussee De Wavre, 1945 1945 Brussels Belgium
  • Lubrizol Europe Coordination Center BVBA 02 , Chaussee De Wavre 1945 Brussels Belgium
  • Lubrizol Europe Coordination Center BVBA 05, Chaussee De Wavre 1945 Brussels Belgium
  • Lubrizol Europe Coordination Center BVBA 06, Chaussee De Wavre 1945 Brussels Belgium
  • Lubrizol Europe Coordination Center BVBA 07, Chaussee De Wavre 1945 Brussels Belgium
  • Lubrizol Europe Coordination Center BVBA 09, Chaussee De Wavre 1945 Brussels Belgium
  • Lubrizol Europe Coordination Center BVBA 12, Chaussee De Wavre 1945 Brussels Belgium
  • Lubrizol Europe Coordination Center BVBA 16, Chaussee De Wavre 1945 Brussels Belgium
  • Lubrizol Europe Coordination Center BVBA 33, Chaussee De Wavre 1945 Brussels Belgium
  • Lubrizol France SAS, 25 Quai de France 76100 ROUEN France
  • LyondellBasell Industries Holdings BV_OR1_Equistar, Delftseplein 27E 3013AA Rottterdan Netherlands
  • Manufacture Française des Pneumatiques Michelin, Place des Carmes Déchaux 63040 Clermont-Ferrand Puy de Dôme France
  • MHM Holding GmbH, Sonnenallee 1 D-85551 Kirchheim Germany
  • Michelin Polska Sp. z o.o., ul. Leonharda 9 10-454 Olsztyn Poland
  • MICHELMAN INTERNATIONAL BELGIUM SRL, Zoning Industriel B-6790 Aubange Belgium
  • Mitsui Chemicals Europe GmbH, Oststr. 34 40211 Dusseldorf Germany
  • MOEHS CANTABRA, P.I.Requejada Z-23 39313 Polanco Cantabria Spain
  • MOL Hungarian Oil and Gas Public Limited Company, Dombóvári út 28 1117 Budapest Hungary
  • Nalco Europe B.V., Oude Rhijnhofweg 17 2342 BB Oegstgeest Netherlands
  • Nouryon Chemicals NV/SA, Parc Industriel de Ghlin Zone A 7011 Ghlin Mons Belgium
  • Nouryon Functional Chemicals B.V., Haaksbergweg 88 1101 BZ Amsterdam The Netherlands Netherlands
  • Nouryon Surface Chemistry AB, Box 47067 40258 Göteborg Sweden
  • NuCera Solutions France SARL, Wojo Saint-Lazare 18 Rue de Londres 75009 Paris France France
  • Penpet Petrochemical Trading GmbH, Merkurring 105 22143 Hamburg Germany
  • Polymer Solutions Ibérica, S.L.U., Valle de Tamón - Nubledo Att: Javier Francos 33469 Tamón – Carreño Asturias Spain
  • POLYNT S.p.A., via Enrico Fermi, 51 I-24020 Scanzorosciate BG Italy
  • PPG Europe B.V. - OR3, Amsterdamseweg 14 1422 AD Uithoorn Netherlands
  • PPG Industries Italia Srl Società soggetta a direzione e coordinamento da parte di PPG Industries Inc., Via Serra, 1 15028 Quattordio Italy
  • REACH24H CONSULTING GROUP, Paramount Court, Corrig Road, Sandyford Dublin18 Dublin Ireland
  • REACH24H CONSULTING GROUP, Paramount Court, Corrig Road, Sandyford Dublin 18 Dublin Ireland
  • REACH24H Consulting Group, Paramount Court, Corrig Road, Sandyford Dublin 18 Dublin Ireland
  • REACHLaw Ltd, Aleksanterinkatu 19 00100 Helsinki Finland
  • REACHLaw Ltd., Aleksanterinkatu 19 00100 Helsinki Finland
  • REACHLINKED OÜ, Ahtri tn 12 10151 Tallinn Estonia
  • Red Orchid Consulting Oy Ltd(Zibo Qixiangtengda chemical Co., Ltd), Viherkallionkuja 3 I 59 02710 Espoo Finland
  • RHODIA OPERATIONS - 17, 9 rue des Cuirassiers Immeuble Silex 2 Solvay 69003 Lyon France
  • RHODIA OPERATIONS - 2, 9 rue des Cuirassiers Immeuble Silex 2 Solvay 69003 Lyon France
  • Roehm America LLC - ORR1, Deutsche-Telekom-Allee 9 64295 Darmstadt Germany
  • Ruse Chemicals, 133, Bulgaria blvd. 7000 Rousse Bulgaria
  • Röhm GmbH, Deutsche-Telekom-Allee 9 64295 Darmstadt Germany
  • SI Group DEAB (Imp), Teplitzer Strasse 84478 Waldkraiburg Germany
  • SIGMA-ALDRICH CHEMIE GMBH, Riedstrasse 2 89555 Steinheim Germany
  • SK FUNCTIONAL POLYMER, 16 PLACE DE L'IRIS 92400 COURBEVOIE France
  • SNF SA, ZAC de Milieux 42163 Andrézieux France
  • Solenis Netherlands B.V., Pesetastraat 62 2991 XT Barendrecht Netherlands
  • SOLVAY SOLUTIONS NEDERLAND B.V., ENERGIEWEG 1 4791RN Klundert Netherlands
  • SP Automotive GmbH, Viktoriastr. 32-36 56068 Koblenz Germany
  • Stafford-Miller (Ireland) Limited, Clocherane Youghal Road _ Dungarvan Waterford Ireland
  • STEPAN EUROPE SA, Chemin JONGKIND 38340 VOREPPE France
  • Synthomer Trading Limited Dutch Branch, IJsselstraat 41 5437KG Oss Netherlands
  • TCL GLOBAL BV as ONLY REPRESENTATIVE OF OOSB, Saturnusstraat 46-62 2132 HB Hoofddorp Netherlands
  • TFL Ledertechnik GmbH, Peter-Krauseneck-Strasse 16 79618 Rheinfelden Germany
  • TramacoGmbH, Lise-Meitner-Allee 8 25411 Tornesch Germany
  • TÜV SÜD Iberia S.A.U. (003), Ronda Can Fatjó 13 08290 Cerdanyola del Vallès Barcelona Spain
  • TÜV SÜD Iberia S.A.U. (051), Ronda Can Fatjó 13 08290 Cerdanyola del Vallès Barcelona Spain
  • Veolia Water Technologies & Solutions Belgium BVBA, Toekomstlaan 54 2200 Herentals Belgium
  • Veolia WTS France, Immeuble L'Aquarène 1 place Montgolfier 94417 SAINT-MAURICE CEDEX France
  • Vertellus Specialties Austria GmbH, St.-Peter-Straße 25 4020 Linz Austria
  • Vertellus Specialties Belgium NV, Havenlaan 86-C- bus 204 1000 Brussels Belgium
  • Wacker Chemie AG, Hanns-Seidel-Platz 4 81737 Muenchen Germany
  • WEGeuro - Indústria Eléctrica, S.A., Rua Engº Frederico Ulrich, Zona industrial da Maia sector V 4470-605 Maia Porto Portugal
  • [Confidential], [Confidential]
  • Chemours Netherlands B.V., Baanhoekweg 22 3313 LA Dordrecht Netherlands
  • Colors & Effects France S.A.S., Rue de la Chapelle 28 68330 Huningue France
  • COMPANÍA ESPAÑOLA DE PETRÓLEOS, S.A (CEPSA), Torre Cepsa, Paseo de la Castellana 259A 28046 Madrid Spain
  • Grupa Azoty Zakłady Azotowe Kędzierzyn Spółka Akcyjna, skr. poczt. 163 ul. Mostowa 30A 47-220 Kędzierzyn-Kożle Poland
  • Huntsman (Europe) BV - OR4, Everslaan 45 B-3078 Everberg Belgium
  • Intertek Deutschland GmbH, Stangenstrasse 1 D-70771 Leinfelden-Echterdingen Germany
  • Lubrizol Limited 16, The Knowle,Nether Lane DE56 4AN Derby Derbyshire United Kingdom
  • Nippon Gohsei UK Ltd, Soarnol House Saltend HU12 8DS Hull East Yorkshire United Kingdom
  • Only representative (No publishable name), null
  • POLYNT S.p.A. OR1, via Enrico Fermi, 51 I-24020 Scanzorosciate BG Italy
  • Stewardship Chemicals 28, Długosza 67 43-188 Orzesze Poland
  • [Confidential], [Confidential]

Substance names and other identifiers

2,5-Furandione
Other
Anhydrid kyseliny maleinove
Other
cis-Butenedioic anhydride
Other
Dihydro-2,5-dioxofuran
Other
Maleic acid anhydride
Other
Maleic anhydride
EC Inventory, C&L Inventory, Substance Evaluation - CoRAP, REACH pre-registration, Other, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, End-of-Life Vehicles Directive - Hazardous Substances, Active Implantable Medical Devices Directive - Hazardous Substances, Inland Transport of Dangerous Goods Directive, Annex I - ADR, Inland Transport of Dangerous Goods Directive, Annex II - RID, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Regulation - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, Medical Devices Regulation - Hazardous Substances, FCM and Articles Regulation, Annex I - Authorised Substances, General Product Safety Directive - Hazardous Substances, FCMs Recycled Plastic & Articles Regulation - Annex I - Authorised Use, Recycled Plastic FCMs - Regulation (EU) 2022/1616, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Physical, Biological and Chemical Agents & Processes and Work
MALEIC ANHYDRIDE
C&L Inventory, Substance Evaluation - CoRAP, REACH pre-registration, Other, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, End-of-Life Vehicles Directive - Hazardous Substances, Active Implantable Medical Devices Directive - Hazardous Substances, Inland Transport of Dangerous Goods Directive, Annex III - ADN, Inland Transport of Dangerous Goods Directive, Annex I - ADR, Inland Transport of Dangerous Goods Directive, Annex II - RID, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Regulation - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, Medical Devices Regulation - Hazardous Substances, FCM and Articles Regulation, Annex I - Authorised Substances, General Product Safety Directive - Hazardous Substances, FCMs Recycled Plastic & Articles Regulation - Annex I - Authorised Use, Recycled Plastic FCMs - Regulation (EU) 2022/1616, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Physical, Biological and Chemical Agents & Processes and Work
MALEIC ANHYDRIDE, MOLTEN
Inland Transport of Dangerous Goods Directive, Annex III - ADN, Inland Transport of Dangerous Goods Directive, Annex I - ADR, Inland Transport of Dangerous Goods Directive, Annex II - RID
Maleinanhydrid
Other
Toxilic anhydride
Other
anhidrid maleinske kisline (sl)
C&L Inventory
anhidrida maleica (ro)
C&L Inventory
anhydride maléique (fr)
C&L Inventory
anhídrido maleico (es)
C&L Inventory
anidride maleica (it)
C&L Inventory
anidrido maleico (pt)
C&L Inventory
bezwodnik maleinowy (pl)
C&L Inventory
Maleiinanhüdriid (et)
C&L Inventory
maleiinianhydridi (fi)
C&L Inventory
maleinanhydrid (cs)
C&L Inventory
maleinezuuranhydride (nl)
C&L Inventory
maleino rūgšties anhidridas (lt)
C&L Inventory
maleinsav-anhidrid (hu)
C&L Inventory
maleinsyraanhydrid (sv)
C&L Inventory
maleinsyreanhydrid (da)
C&L Inventory
maleinsyreanhydrid (no)
C&L Inventory
Maleinsäureanhydrid (de)
C&L Inventory
maleínanhydrid (sk)
C&L Inventory
maleīnanhidrīds (lv)
C&L Inventory
μηλεϊνικός ανυδρίτης (el)
C&L Inventory
анхидрид на малеиновата киселина (bg)
C&L Inventory
2,5-dihydrofuran-2,5-dione
C&L Inventory, Registration dossier, Other
2,5-Furandione
C&L Inventory, Registration dossier
butenedioic anhydride, toxilic anhydride, 2,5-dioxofuran
C&L Inventory
Cis-butenedioic anhydride
C&L Inventory
fruan-2,5-dione
Registration dossier
Furan - 2,5 - dione
C&L Inventory
Furan-2,5 dione
Registration dossier
furan-2,5-dion
C&L Inventory
Furan-2,5-dione
C&L Inventory, Registration dossier, Other
Furan-2.5-dione
C&L Inventory
Furane-2,5-dione
C&L Inventory
Maleic Abhydride
C&L Inventory
MALEIC ANHYDRIDE
C&L Inventory, Registration dossier
Maleic Anhydride
C&L Inventory, Registration dossier
Maleinsäureanhydrid
C&L Inventory
Maleinsäureanhydrid
Registration dossier
MAN
Registration dossier
2,5 Furandione
Registration dossier
2,5-Diossi-diidrofurano
Registration dossier
2,5-Dioxo-dihydrofuran
Registration dossier
2,5-Furandion
Registration dossier
2,5-Furandion, MSA, cis-Butensäureanhydrid
Registration dossier
2,5-FURANDIONE
Registration dossier
2,5-Furandione (9CI)
Registration dossier
2,5-Furandione (9Cl)
Registration dossier
2,5-Furandione, Maleinsäureanhydrid
Registration dossier
2,5-Furanedione
Registration dossier
2,5-FURANEDIONE. TOXILIC ANHYDRIDE.CIS-BUTENEDIOIC ANHYDRIDE
Registration dossier
2-5 Furandiona
Registration dossier
2-Butendicarbonsaeureanhydrid
Registration dossier
2.5 furandion
Registration dossier
A-C® 573, A-C® 596P, 597A, 597P, 950A, 950P, 1325P
Registration dossier
Anhydride maleique; cis-butenedioic anhydride
Registration dossier
ANHYDRIDE MALÉIQUE BRIQUETTE
C&L Inventory
Anidride Cis-Butendioica
Registration dossier
Anidride dell'acido cis-etilendicarbossilico
Registration dossier
Anidride dell'acido maleico
Registration dossier
Anidride Maleica
Registration dossier
Anidride maleica solida
C&L Inventory
Anidride tossilica
Registration dossier
Aropol
Registration dossier
bezwodnik maleinowy
Registration dossier
BM 10
Registration dossier
cis- Ethendicarboxylic Anhydride
Registration dossier
cis-Butanedioic anhydride
Registration dossier
cis-butendioc anhydride
Registration dossier
CIS-BUTENEDIOIC ANHYDRIDE
Registration dossier
cis-Butenedioic anhydrides Maleic anhydride
Registration dossier
cis-Butensäureanhydrid
Registration dossier
cis-Butensäureanhydrid, MSA
Registration dossier
cis-Ethendicarbonsaeureanhydrid
Registration dossier
Crystal Man
Registration dossier
Dihydro-2,5-dioxofuran
Registration dossier
EPS
Registration dossier
Ethylendicarbonsaeureanhydrid
Registration dossier
furan-2,5-dione
Registration dossier
furandione
Registration dossier
MA
Registration dossier
MALEIC ACID ANHYDRIDE
Registration dossier
Maleic acid anhydride, cis-Butenedioic anhydride.
Registration dossier
Maleic Anhydride
Registration dossier
Maleic anhydride (8CI)
Registration dossier
maleic anhydride (8Cl)
Registration dossier
Maleic anhydride; cis-butenedioc anhydride; maleic acid anhydride
Registration dossier
Maleicanhydride
Registration dossier
Maleinsaeureanhydrid
Registration dossier
Maleinsavanhidrid
Registration dossier
Maleinsäureanhydrid
Registration dossier
MAN
Registration dossier
Maxguard
Registration dossier
MSA
Registration dossier
Nourymix MA 901
Registration dossier
Polybond 2006
Registration dossier
Polybond 2021
Registration dossier
Polybond 2021P
Registration dossier
Polybond 3001
Registration dossier
Polybond 3002
Registration dossier
Polybond 3005
Registration dossier
Polybond 3009
Registration dossier
TOXILIC ANHYDRIDE
Registration dossier
108-31-6
CAS number
EC Inventory, C&L Inventory, Substance Evaluation - CoRAP, Registration dossier, REACH pre-registration, Other, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, End-of-Life Vehicles Directive - Hazardous Substances, Active Implantable Medical Devices Directive - Hazardous Substances, Inland Transport of Dangerous Goods Directive, Annex III - ADN, Inland Transport of Dangerous Goods Directive, Annex I - ADR, Inland Transport of Dangerous Goods Directive, Annex II - RID, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Regulation - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, Medical Devices Regulation - Hazardous Substances, FCM and Articles Regulation, Annex I - Authorised Substances, General Product Safety Directive - Hazardous Substances, FCMs Recycled Plastic & Articles Regulation - Annex I - Authorised Use, Recycled Plastic FCMs - Regulation (EU) 2022/1616, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Physical, Biological and Chemical Agents & Processes and Work
1190407-73-8
CAS number
Other
1229972-04-6
CAS number
Other
1380217-40-2
CAS number
Other
184288-31-1
CAS number
Other
607-096-00-9
Index number
C&L Inventory

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 4 studies submitted
  • 4 studies processed
C Physical state at 20°C and 1013 hPa
Solid (100%) [4]
C Form
Other (67%), Solid (33%) [3]
C Odour
Other (100%) [1]
C Substance type
Organic (100%) [4]

Type of Study provided
Studies with data
Key study 2 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Physical state at 20°C and 1013 hPa
Solid (100%)
Form
Solid (100%)
Colour
white (100%)
Colour Intensity
light (100%)

Melting/freezing point

Study results
  • 7 studies submitted
  • 3 studies processed
R Melting / freezing point
51.2 - 58 °C [3]

Type of Study provided
Studies with data
Key study 3
Supporting study 2 1
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Melting / freezing point at 101 325 Pa
53 - 55 °C

Boiling point

Study results
  • 6 studies submitted
  • 3 studies processed
R Boiling point
185 - 200.1 °C @ 101 - 101.37 kPa [3]

Type of Study provided
Studies with data
Key study 3
Supporting study 2
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Boiling point at 101 325 Pa
200 - 200.1 °C

Density

Study results
  • 5 studies submitted
  • 3 studies processed
R Density
1.3 - 1.48 g/cm³ @ 20 - 60 °C [2]
R Relative density
1.48 @ 20 °C [2]

Type of Study provided
Studies with data
Key study 1
Supporting study 1 1
Weight of evidence 2
Other
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 3 summaries processed
Relative density at 20°C
1.48 - 1 480

Vapour pressure

Study results
  • 7 studies submitted
  • 3 studies processed
R Vapour pressure
15.1 - 108 Pa @ 22 - 40 °C [9]

Type of Study provided
Studies with data
Key study 2 1
Supporting study 2 1
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Vapour pressure
15.1 - 21.332 Pa @ 20 - 22 °C

Partition coefficient

Study results
  • 5 studies submitted
  • 3 studies processed
R Log Pow
-2.78 - -2.36 @ 19.8 °C and pH 4 - 9 [5]

Type of Study provided
Studies with data
Key study 2 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Log Kow (Log Pow)
-2.61 @ 20 °C

Water solubility

Study results
  • 4 studies submitted
  • 2 studies processed
R Water solubility (mass/vol.)
400 - 418 g/L @ 20 °C and pH 4 - 9 [4]

Type of Study provided
Studies with data
Key study 1 1
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
R Summaries
  • 1 summary submitted
  • 1 summary processed
Water solubility
407 g/L @ 20 °C

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Flash point

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 2
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other 1
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Flash point at 101 325 Pa
103.333 °C

Auto flammability

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 2
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Flammability

Study results
  • 3 studies submitted
  • 2 studies processed
C Interpretation of results
Not classified based on GHS criteria (50%), Non flammable (50%) [2]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence 1
Other 1
Data waiving
no waivers
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Flammability
Non flammable (100%)

Explosiveness

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
C Summaries
  • 1 summary submitted
  • 1 summary processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
C Summaries
  • 1 summary submitted
  • 1 summary processed
Oxidising
No (100%)

Oxidation reduction potential

Data not provided by the registrant

pH

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers

No summary exists for this scientific endpoint

Dissociation constant

Study results
  • 2 studies submitted
  • 1 study processed
C Dissociating properties
Yes (100%) [1]
R Dissociation constant
0 - 0.011 @ 25 °C [2]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
R Summaries
  • 1 summary submitted
  • 1 summary processed
pKa at 20 °C
0

Viscosity

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 5 studies submitted
  • 1 study processed
R Dissipation half life (DT50)
8.5 h [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 3 1
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Hydrolysis

Study results
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half-life for hydrolysis
18 s @ 25.1 °C

Phototransformation in water

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in soil

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in water - screening tests

Study results
  • 12 studies submitted
  • 3 studies processed
C Interpretation of results
Readily biodegradable (100%) [3]

Type of Study provided
Studies with data
Key study 3 1
Supporting study 4 1
Weight of evidence
Other 3
Data waiving
no waivers
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Biodegradation in water
Readily biodegradable (100%)
Type of water
Freshwater (100%)

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in soil

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: aquatic / sediment

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: terrestrial

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Adsorption/desorption

Study results
  • 5 studies submitted
  • 1 study processed
R Koc
42 dimensionless [1]
R log Koc
1.63 dimensionless [1]

Type of Study provided
Studies with data
Key study 1 1
Supporting study 1 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
R Summaries
  • 1 summary submitted
  • 1 summary processed
Koc at 20°C
42

Henrys law constant (H)

Study results
  • 3 studies submitted
  • 1 study processed
R H - (pressure) m³/mol
0 Pa m³/mol @ 25 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Henry's law constant
0 Pa.m³.mol-1 @ 25 °C

Distribution modelling

Study results
  • 2 studies submitted
  • 1 study processed
% Distribution in Media:
R Air 0 % [1]
R Water 100 % [1]
R Soil 0 % [1]
R Sediment 0 % [1]
R Suspended sediment 0 % [1]
R Biota 0 % [1]
R Aerosol 0 % [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers

No summary exists for this scientific endpoint

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 2 summaries submitted
  • 2 summaries processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 37.9 - 75 µg/L (2)
Intermittent releases (freshwater) 379 - 750 µg/L (2)
Marine water 3.79 - 7.5 µg/L (2)
Intermittent releases (marine water) 37.9 µg/L (1)
Sewage treatment plant (STP) 4.46 - 44.6 mg/L (2)
Sediment (freshwater) 60 - 296 µg/kg sediment dw (2)
Sediment (marine water) 6 - 29.6 µg/kg sediment dw (2)
Hazard for Air
Air No hazard identified (1)
Hazard for Terrestrial Organism
Soil 10 - 36.9 µg/kg soil dw (2)
Hazard for Predators
Secondary poisoning 6.67 mg/kg food (1)

Short–term toxicity to fish

Study results
  • 17 studies submitted
  • 2 studies processed
P/RResults
LC50 (4 days) 75 mg/L [2]
LC50 (48 h) 75 mg/L [2]
LC50 (24 h) 75 mg/L [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 1
Weight of evidence 2
Other 11 1
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to fish

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Short–term toxicity to aquatic invertebrates

Study results
  • 9 studies submitted
  • 2 studies processed
P/RResults
EC50 (48 h) 42.81 - 330 mg/L [2]
EC50 (24 h) 340 mg/L [1]
NOEC (48 h) 17.5 mg/L [1]
LOEC (48 h) 30.63 mg/L [1]

Type of Study provided
Studies with data
Key study 2 1
Supporting study 3 1
Weight of evidence
Other 2
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic algae and cyanobacteria

Study results
  • 7 studies submitted
  • 2 studies processed
P/RResults
EC50 (72 h) 74.35 - 150 mg/L [3]
NOEC (72 h) 150 mg/L [2]
EC10 (72 h) 11.8 mg/L [1]
EC20 (72 h) 22.2 mg/L [1]

Type of Study provided
Studies with data
Key study 2 1
Supporting study 1
Weight of evidence
Other 3
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
EC50 for freshwater algae
65.78 - 150 mg/L
EC10 or NOEC for freshwater algae
10.4 - 150 mg/L

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 12 studies submitted
  • 2 studies processed
P/RResults
EC50 (15 min) 12.5 mg/L [1]
EC10 (18 h) 44.6 mg/L [1]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 7 1
Other 4
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
EC10 or NOEC for microorganisms
44.6 mg/L

Sediment toxicity

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons. 1
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons. 1
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial arthropods

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons. 1
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial plants

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons. 1
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to soil microorganisms

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons. 1
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to birds

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 81 µg/m³ irritation (respiratory tract)
Acute /short term: (DNEL) 200 µg/m³ irritation (respiratory tract)
Local Effects
Long-term: (DNEL) 81 µg/m³ irritation (respiratory tract)
Acute /short term: (DNEL) 200 µg/m³ irritation (respiratory tract)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 200 µg/kg bw/day repeated dose toxicity
Acute /short term: (DNEL) 200 µg/kg bw/day repeated dose toxicity
Local Effects
Long-term: (High hazard (no threshold derived)) -
Acute /short term: (High hazard (no threshold derived)) -
EYE Exposure
High hazard (no threshold derived)
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 50 µg/m³ repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: (DNEL) 80 µg/m³ repeated dose toxicity
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 100 µg/kg bw/day repeated dose toxicity
Acute /short term: (DNEL) 100 µg/kg bw/day repeated dose toxicity
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 60 µg/kg bw/day effect on fertility
Acute /short term: (DNEL) 100 µg/kg bw/day repeated dose toxicity
EYE Exposure
No hazard identified

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 1
Supporting study 1
Weight of evidence 1
Other
Data waiving
no waivers
Study data: dermal absorption
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Bioaccumulation potential:
No bioaccumulation potential

Acute toxicity

Study results
oral
  • 12 studies submitted
  • 2 studies processed
P/RResults
LD50 1 000 - 1 090 mg/kg bw (rat) [2]
M/CInterpretations of results
Category 4 based on GHS criteria [1]

Type of Study provided
oral
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other 8
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
inhalation
  • 5 studies submitted
  • 0 studies processed

No automatically processable data submitted

inhalation
Studies with data
Key study
Supporting study 2
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
dermal
  • 7 studies submitted
  • 2 studies processed
P/RResults
LD50 1 600 - 2 620 mg/kg bw (rabbit) [2]
M/CInterpretations of results
GHS criteria not met [1]

dermal
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other 3
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Oral route:
Adverse effect observed LD50 1 090 mg/kg bw
Dermal route:
Adverse effect observed LD50 2 620 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 9 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other 4
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Study data: eye
  • 9 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other 4
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Skin
Adverse effect observed (corrosive)
Eye
Adverse effect observed (irreversible damage)
Respiratory
Adverse effect observed (irritating)

Sensitisation

Study results
Study data: skin
  • 8 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other 3
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Study data: respiratory
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Skin sensitisation
Adverse effect observed (sensitising)
Respiratory sensitisation
Adverse effect observed (sensitising)

Repeated dose toxicity

Study results
Study data: oral
  • 10 studies submitted
  • 5 studies processed
P/RResults
NOAEL (rat): 10 - 250 mg/kg bw/day [2]
NOAEL (dog): 60 mg/kg bw/day [1]
LOAEL (rat): 100 - 600 mg/kg bw/day [2]
NOEL (rat): 10 - 40 mg/kg bw/day [2]
LOEL (rat): 32 mg/kg bw/day [1]

Type of Study provided
Study data: oral
Studies with data
Key study 1
Supporting study 3 1
Weight of evidence 4
Other 1
Data waiving
no waivers
Study data: inhalation
  • 9 studies submitted
  • 8 studies processed
P/RResults
NOAEL (other:): 3.3 - 9.8 mg/m³ air [2]
NOAEC (rat): 3.3 mg/m³ air [2]
NOAEC (hamster): 9.8 mg/m³ air [2]
NOAEC (monkey): 9.8 mg/m³ air [2]
LOAEC (rat): 1.1 - 10 mg/m³ air [4]

Study data: inhalation
Studies with data
Key study 4
Supporting study 1
Weight of evidence 4
Other
Data waiving
no waivers
Study data: dermal
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Oral route - systemic effects:
No adverse effect observed NOAEL 60 mg/kg bw/day (subchronic, dog)
Inhalation route - systemic effects:
Adverse effect observed NOAEC 3.3 mg/m³ (subchronic, rat)
Inhalation route - local effects:
Adverse effect observed LOAEC 1.1 mg/m³ (subchronic, rat)

Genetic toxicity

Study results
Study data: in vitro
  • 12 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study
Supporting study 4
Weight of evidence 6 1
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: in vivo
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study
Supporting study 1
Weight of evidence 2
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Toxicity - InVitro
No adverse effect observed (negative)
Toxicity - InVivo
No adverse effect observed (negative)

Carcinogenicity

Study results
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other 1
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Oral route:
No adverse effect observed NOAEL 100 mg/kg bw/day (chronic, rat)

Toxicity to reproduction

Study results
Study data: reproduction
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: developmental
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Effect on fertility
Oral route:
No adverse effect observed NOAEL 55 mg/kg bw/day (chronic, rat)
Effect on developmental toxicity
Oral route:
No adverse effect observed NOAEL 140 mg/kg bw/day (subacute, rat)

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant