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EC number: 603-501-8 | CAS number: 13171-18-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 28 February 2019 thru 17 April 2019
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 019
- Report date:
- 2019
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Version / remarks:
- 2009
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1300 (Acute inhalation toxicity)
- Version / remarks:
- 1998
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- traditional method
- Limit test:
- yes
Test material
- Reference substance name:
- 1,1,1,3,3,3-hexafluoro-2-methoxypropane
- Cas Number:
- 13171-18-1
- Molecular formula:
- C4-H4-F6-O
- IUPAC Name:
- 1,1,1,3,3,3-hexafluoro-2-methoxypropane
- Test material form:
- liquid: volatile
Constituent 1
- Specific details on test material used for the study:
- CASNo.: 13171-18-1
Lot #: HFMOP17004
Storage: Room Temp.
Purity: >99.99%
Description: Clear Liquid
pH: Neutral molecule
Stability: Expected to be stable for the duration of testing.
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: SAGE Labs on February 20 and March 27, 2019
- Females (if applicable) nulliparous and non-pregnant: Yes
- Age at study initiation: Young adult (8 - 9 weeks)
- Weight at study initiation: males; 252 - 313 grams Females; 160 - 201 grams
- Fasting period before study: Yes
- Housing: Stainless steel cages with enrichment (e.g. toys) and litter paper under the cage changed at least once per week.
- Diet (e.g. ad libitum): Envigo Teklad Global 16% Protein Diet ad libitum except during exposure.
- Water (e.g. ad libitum): Filtered tap water ad libitum except during exposure.
- Acclimation period: 7 or 8 days.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 - 23
- Humidity (%): 37 - 69
- Air changes (per hr): 13
- Photoperiod (hrs dark / hrs light): 12
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- nose only
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: ADG Developments LTD 28 liter (Nose-Only Inhalation Chamber)
- Exposure chamber volume: 28 liter
- Method of holding animals in test chamber: polycarbonate holding tubes
- Source and rate of air: Filtered generator air delivered by an air compressor
- Method of conditioning air: Filtered
- System of generating particulates/aerosols: not applicable
- Method of particle size determination: not applicable
- Temperature and humidity in air chamber: 21 - 23 deg C; 27 - 49%
TEST ATMOSPHERE
- Brief description of analytical method used: Air samples collected on Anosorb CSC tubes (SKC Lot #2000), desorbed with toluene, and analyzed by GC-FID. See OSHA Method 106 "Desflurane".
- Samples taken from breathing zone: yes
VEHICLE
- Composition of vehicle (if applicable): air
- Concentration of test material in vehicle (if applicable): 243.12 mg/L nominal
- Justification of choice of vehicle: not applicable.
- Lot/batch no. (if required): not applicable.
- Purity: not applicable.
TEST ATMOSPHERE (if not tabulated)
- Particle size distribution: not applicable.
- MMAD (Mass median aerodynamic diameter) / GSD (Geometric st. dev.): not applicable.
CLASS METHOD (if applicable)
- Rationale for the selection of the starting concentration: A nominal starting concentration of 7500 ppm was chosen based on an LC50 for the substance for which the reliability could not be determined. Since there were no deaths at that concentration, the study was performed at the nominal limit dose of 20000 ppm. - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- 7322 ppm (measured) and 24685 ppm (measured)
- No. of animals per sex per dose:
- 5 males, 5 females at each dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Upon removal from the chamber and at least once daily
- Necropsy of survivors performed: yes. Gross necropsies were performed on all animals. Tissues and organs of the thoracic and abdominal cavities were examined.
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: Observations included gross evaluation of skin and fur, eyes and mucous membranes, respiratory, circulatory, autonomic and central nervous systems, somatomotor activity and behavior pattern. Particular attention was directed to observation of tremors, convulsions, salivation, diarrhea, and coma. - Statistics:
- Statistical analysis was limited to the calculation of the mean and standard deviation
Results and discussion
- Preliminary study:
- No deaths reported at 7322 ppm.
Effect levelsopen allclose all
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 24 685 ppm
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: (analytical)
- Remarks:
- molecular weight=182.07
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 183.82 mg/L air (analytical)
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- 24 685 ppm
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- None
- Clinical signs:
- other: Following exposure, all rats exhibited irregular respiration. However, all animals recovered by Day 1 and appeared active and healthy for the remainder of the 14-day observation period.
- Body weight:
- Normal
- Gross pathology:
- No gross abnormalities were noted for any of the animals when necropsied at the conclusion of the 14-day observation period.
- Other findings:
- None.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Remarks:
- Substance is a highly volatile liquid. GHS-criteria for gases was applied.
- Conclusions:
- The substance (vapor only) was found to be non-toxic to rats at the limit concentration of 24685 ppm (183.82 mg/L) for four hours. Therefore, the 4-hour LC50 in rats is >24685 ppm.
- Executive summary:
In a GLP guideline study conducted according to OECD Method 403 (2009) to assess the acute inhalation toxicity with 5 male and 5 female Sprague-Dawley young adult rats, no mortalities were observed at either 7322 ppm or 24685 ppm for 4 -hours. All animals exhibited irregular respiration immediately following exposrue but recovered by day 1 and were healthy and active throughout the remainder of the 14 -day observation period. There were no gross abnormalities observed at necropsy. Therefore, the 4 -hour LC50 is >24685 ppm (183.82 mg/L).
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