Aluminium sulphate

Specific investigations: other studies

Description of key information

-In the study of Hermenegildo C, et al.1999,  the results indicate that chronic exposure to aluminium  in the drinking water (2.5% aluminium sulfate) reduces the basal activity of guanylate cyclase and impairs the glutamate-nitric oxide-cGMP pathway in the animal in vivo.
-In the  vivo study of Swain C, Chainy GB 1998 was demonstrates that only CN -sensitive SOD is susceptible to Al as aluminum sulphate. Further, responses of SOD and catalase to Al is tissue specific. The observed inhibition of antioxidant enzyme activities by Al is suggestive of a prooxidant state. Induction of such an oxidative condition of the tissues may be attributed to a direct effect of the metal on enzyme molecules or in their synthesis.
-In the  study of HAMED Manal A.2006, was demonstrates that the effect of different doses of aluminum sulphate within weeks, ANOVA test revealed significant variation among each group except normal control group which recorded insignificant change after 1st, 2nd, and 3nd week. In vitamin C-administrated healthy mice, only albumin concentration and bilirubin levels recorded a non significant variations within different weeks.
-In the  study of Huff WE, et al 1996 the data indicate that aluminium sulphate can be toxic to young broiler chicks, but at levels that would not be expected to be reached through litter consumption, and that aluminium sulphate did not increase intestinal strength.
-In the study of Hussein AS et al.1990 was demonstrates that after 21 days, the supplemental Al resulted in: 1) significantly poorer growth performance; 2) decreased plasma Pi, total Ca, Zn, and Mg; and 3) decreased tibia weight and breaking strength.
-In the study of Alessandra Stacchiotti, 2008, was demonstrates that prolonged Al sulphate intake accelerates features of senescence in the adult mice liver.

Additional information

-In the study of Hermenegildo C, et al.1999, the results indicate that chronic exposure to aluminium in the drinking water (2.5% aluminium sulfate) reduces the basal activity of guanylate cyclase and impairs the glutamate-nitric oxide-cGMP pathway in the animal in vivo.

 

-In the vivo study of Swain C, Chainy GB 1998 was demonstrates that only CN -sensitive SOD is susceptible to Al as aluminum sulphate. Further, responses of SOD and catalase to Al is tissue specific. The observed inhibition of antioxidant enzyme activities by Al is suggestive of a prooxidant state. Induction of such an oxidative condition of the tissues may be attributed to a direct effect of the metal on enzyme molecules or in their synthesis.

 

-In the study of HAMED Manal A.2006, was demonstrates that the effect of different doses of aluminum sulphate within weeks, ANOVA test revealed significant variation among each group except normal control group which recorded insignificant change after 1st, 2nd, and 3nd week. In vitamin C-administrated healthy mice, only albumin concentration and bilirubin levels recorded a non significant variations within different weeks.

 

-In the study of Huff WE, et al 1996 the data indicate that aluminium sulphate can be toxic to young broiler chicks, but at levels that would not be expected to be reached through litter consumption, and that aluminium sulphate did not increase intestinal strength.

 

-In the study of Hussein AS et al.1990 was demonstrates that after 21 days, the supplemental Al resulted in: 1) significantly poorer growth performance; 2) decreased plasma Pi, total Ca, Zn, and Mg; and 3) decreased tibia weight and breaking strength.

 

-In the study of Johnson GV, Jope RS. 1987, the results indicate that: the metabolism of cyclic AMP and of cyclic GMP are more sensitive to aluminum than are presynaptic cholinergic processes; the metabolism of cyclic AMP is more sensitive to the effects of aluminum than is the metabolism of cyclic GMP; and cortical cAMP metabolism is the most sensitive to the presence of aluminum. Possible consequences of elevated levels of cyclic nucleotides induced by aluminum in the brain are proposed.

 

-In the study of Alessandra Stacchiotti, 2008, was demonstrates that prolonged Al sulphate intake accelerates features of senescence in the adult mice liver.