Registration Dossier
Registration Dossier
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EC number: 687-349-8 | CAS number: 173194-95-1
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 21 October 2013 - 13 December 2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Performed under GLP and OECD method
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2014
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- GLP compliance:
- yes
- Remarks:
- OECD Principles on Good Laboratory Practice (revised 1997, ENV/MC/CHEM(98)17)
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- (6-hydroxynaphthalen-2-yl)boronic acid
- EC Number:
- 687-349-8
- Cas Number:
- 173194-95-1
- Molecular formula:
- C10H9BO3
- IUPAC Name:
- (6-hydroxynaphthalen-2-yl)boronic acid
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- off-white powder
Constituent 1
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficientopen allclose all
- Type:
- log Pow
- Partition coefficient:
- 2.47
- Temp.:
- 21.6 °C
- Remarks on result:
- other: ± 0.1°C
- Type:
- Pow
- Partition coefficient:
- 295
- Temp.:
- 21.6 °C
- Remarks on result:
- other: ± 0.1°C
Any other information on results incl. tables
| Sample nr | Organic/Aqueous Volume Ratio | Partition Coefficient | Log10 Pow | Mean Partition Coefficient |
| 1 | 1:1 | 285 | 2.45 | 285 |
| 2 | 285 | 2.45 | ||
| 3 | 1:2 | 285 | 2.45 | 279 |
| 4 | 274 | 2.44 | ||
| 5 | 2:1 | 336 | 2.53 | 322 |
| 6 | 307 | 2.49 |
Applicant's summary and conclusion
- Conclusions:
- The partition coefficient of the test item has been determined to be 295 at 21.6 ±1.0°C, log10 Pow 2.47.
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