Boronic acid, B-(6-hydroxy-2-naphthalenyl)-

Density

Administrative data

Endpoint:

relative density

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2014

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: In accordance with OECD and EU protocol and GLP methods..

Cross-reference

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2014

Report date:

2014

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 109 (Density of Liquids and Solids)

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

EU Method A.3 (Relative Density)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

pycnometer method

Test material

Test material information

Constituent 1

Reference substance name:

(6-hydroxynaphthalen-2-yl)boronic acid

EC Number:

687-349-8

Cas Number:

173194-95-1

Molecular formula:

C10H9BO3

IUPAC Name:

(6-hydroxynaphthalen-2-yl)boronic acid

Test material form:

solid: particulate/powder

Remarks:

migrated information: powder

Details on test material:

-Chemical Name: 6-hydroxy-2-naphthaleneboronic acid
CAS Number 173194-95-1
- Substance type: off white powder-
- Expiration date of the lot/batch: 13 June 2014
- Storage condition of test material: room temperatire in the dark (08 to 14 October 2013), Approximately 4°C in the dark (onwards)

Results and discussion

Density

Type:

relative density

Density:

ca. 1.36 kg/m³

Temp.:

22.8 °C

Any other information on results incl. tables

Calibration

The pressure readings and the calculated volume for the reference and sample cells, corresponding to the calibration prior to determination 1 are shown in table 1 of attachment below 'Results'.

The pressure readings and the calculated volume for the reference and samples cells, corresponding to the calibration prior to determination 2, are shown in table 2 of attachment below 'Results'.

Sample

The pressure readings, calculated volumes and density values obtained for the test item are shown in table 3 of attachment below 'Results'

Applicant's summary and conclusion

Conclusions:

The density of the test item has been determined to be 1.36 x 1000 kg/m3 at 22.8 ± 0.5 °C.at 22.8 ± 0.5 °C. The corresponding relative density has been calculated to be 1.36.
Although testing would be preferable at 20 °C, this was not possible in the absence of methods of temperature control for the relevant apparatus. Due to the negligible influence of temperature on the density of solids, the method guideline (EC A3) requires that the determination of density of solids is to be performed "at room temperature". It is therefore considered that the effect of temperature within normal laboratory conditions will not have a significant impact on either the determined density or calculated relative density.

The density of a material varies with temperature and pressure. However, this variance is typically negligible for solids within a narrow temperature range. Typical thermal expansion coefficients of solids are in the order of 10e-5 °C(-1) and the volumetric expansion of stainless steel (used for calibration) at 20 °C is approximately 5.2 x 10e-5 °C (-1). Thus, a change in temperature of several degrees will have no significant effect on the volume and hence the density of a solid substance.

Two determinations were performed to ensure a reproducibility of less than ± 20 kg/m3 was obtained.