Registration Dossier
Registration Dossier
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EC number: 205-592-6 | CAS number: 143-22-6
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
In a guideline bacterial gene mutation study (Ames),of BASF AG, 2-(2-(2-butoxyethoxy)ethoxy)ethanol (87% pure) did not cause an increase in mutations when tested at up to 5mg/plate with and without S9 metabolic activation using both a standard plate incorporation and pre-incubation methods of application. The test substance does not cause reverse gene mutation in bacterial strains.
Read-across data from supporting substance (structural analogue or surrogate) also indicate negative genetic toxicity
Short description of key information:
There are conclusive but not suffcient data for the classification of substance 2-(2-(2-butoxyethoxy)ethoxy)ethanol with regard to mutagenicity/genetic toxicity.
It is concluded that the substance2-(2-(2-butoxyethoxy)ethoxy)ethanol does not meet the criteria to be classified for human health hazards for Mutagenicity-Genetic Toxicity
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Based on the hazard assessmentof2-(2-(2-butoxyethoxy)ethoxy)ethanolin section 2.1 and 2.2. in IUCLID 5.3., available data for the substance and following the “Guidance on Information Requirement and Chemical Safety Assessment R.8. Characterisation of dose [concentration]- response for human health” andaccording to the criteria described in Directive 67/548 and in the CLP Regulation:
Directive 67/548 |
Mutagenicity-Genetic Toxicity Muta. Cat. 1; R46 May cause heritable genetic damage. Muta. Cat. 2; R46 May cause heritable genetic damage. Muta. Cat. 3; R68 Possible risk of irreversible effects. |
CLP |
Germ cell mutagenicity Muta. 1A Muta. 1B Muta. 2 H340: May cause genetic defects <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>. H341: Suspected of causing genetic defects <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>. |
It is concluded that the substance2-(2-(2-butoxyethoxy)ethoxy)ethanol does not meet the criteria to be classified for human health hazards for Mutagenicity-Genetic Toxicity
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