Registration Dossier
Registration Dossier
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EC number: 250-002-2 | CAS number: 30018-16-7
Toxicity to microorganisms
Administrative data
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: According to OECD guideline, no indication if GLP, not all of the required measures are distributed
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
- Deviations:
- not specified
- Principles of method if other than guideline:
- -
- GLP compliance:
- not specified
Test material
- Reference substance name:
- (2-ethoxy-1-methyl-2-oxoethyl)triphenylphosphonium bromide
- EC Number:
- 250-002-2
- EC Name:
- (2-ethoxy-1-methyl-2-oxoethyl)triphenylphosphonium bromide
- Cas Number:
- 30018-16-7
- Molecular formula:
- C23H24O2P.Br
- IUPAC Name:
- (2-ethoxy-1-methyl-2-oxoethyl)triphenylphosphonium bromide
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- activated sludge of a predominantly domestic sewage
Study design
- Test type:
- static
- Water media type:
- freshwater
- Total exposure duration:
- 3 h
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 3 h
- Dose descriptor:
- EC50
- Effect conc.:
- 430 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Duration:
- 3 h
- Dose descriptor:
- EC0
- Effect conc.:
- 22.8 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
Any other information on results incl. tables
see attachement
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The 30 minute and 3 hour EC50 for inhibition of the respiration rate of aerobic waste water bacteria for C3-Phosphoniumbromid is
> 100 mg/l (nominal concentration). - Executive summary:
A test was conducted to determine the inhibitory concentration of C3 -Phosphoniumbromide on the respiration of aerobic waste water bacteria according to OECD guideline for testing of chemicals 209. The durations of exposure tested were 30 minutes and 3 hours. The EC50 (30 min) and the EC50 (3 hr) were found to be >100 mg/l based on the nominal concentrations.
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