Registration Dossier
Registration Dossier
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EC number: 200-076-7 | CAS number: 51-03-6
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
An acute toxicity study (96 h) was conducted by Gonsior, G. (2009) according to OECD 203 (1992) guideline, with Oncorhynchus mykiss (10 fish per concentration). It was performed under semi-static conditions, with following concentrations: 0, 0.625, 1.25, 2.5, 5 and 10 mg/L. The LC0 (96 h) was 5 mg/L (nominal) and the NOEC (96 h) was at 0.625 mg/L. No lethal or sublethal effects were observed in the control. In the solvent control one fish died. At 1.25, 2.5 and 5 mg/L the fish were affected by the test item. At 10 mg/L 100% of the fish died within 48 h. The LC50 (96 hours) was 7.07 mg/L.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 7.07 mg/L
Additional information
The study of Gonsior, G. (2009) was conducted according to OECD 203 (1992) guideline and was found to be valid with LC50 of 7.07 mg of Piperonyl butoxide/L after 96 hours. The study is considered as "reliable without restriction".
The results are summarised in the following table:
| Species | Endpoint (exposure duration) | Exposure concentration | Reference |
| Oncorhynchus mykiss | LC50(48, 72, 96 h) | 7.07 mg/L | Gonsior, G. (2009) |
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