Bis(2-ethoxyethyl) ether

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

weight of evidence

Study period:

1941 - 1946

Reliability:

3 (not reliable)

Rationale for reliability incl. deficiencies:

other: see 'Remark'

Remarks:

Study run to a reliable method but not to GLP and no guideline followed and limited information. However it is a peer-reviewed publication.The restriction is also due to the use of the category read accross approach. study was performed not with DEGDEE but with DEGEE, a substance which like DEGDEE is part of the diethylene glycol monoalkyl and dialkyl ethers category. These substances have been demonstrated to be similar in structure, physical/chemical properties and toxicological profile.

Data source

Reference

Reference Type:

publication

Title:

Unnamed

Year:

1947

Report date:

1946

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

GLP compliance:

no

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-(2-ethoxyethoxy)ethanol

EC Number:

203-919-7

EC Name:

2-(2-ethoxyethoxy)ethanol

Cas Number:

111-90-0

Molecular formula:

C6 H14 O3

IUPAC Name:

2-(2-ethoxyethoxy) ethanol

Details on test material:

- Name of test material (as cited in study report): diethylene glycol monoethyl ether
- Molecular formula (if other than submission substance): C6H14O3
- Molecular weight (if other than submission substance): 134
- Smiles notation (if other than submission substance): OCCOCCOCC
- InChl (if other than submission substance): 1S/C6H14O3/c1-2-8-5-6-9-4-3-7/h7H,2-6H2,1H3
- Structural formula attached as image file (if other than submission substance): see Fig.
- Substance type:
- Physical state: liquid
- Analytical purity: specially prepared pure compound

Test animals

Species:

rat

Strain:

other: white

Sex:

not specified

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source:
- Age at study initiation:
- Weight at study initiation:
- Fasting period before study:
- Housing:
- Diet (e.g. ad libitum):
- Water (e.g. ad libitum):
- Acclimation period:

ENVIRONMENTAL CONDITIONS
- Temperature (°C):
- Humidity (%):
- Air changes (per hr):
- Photoperiod (hrs dark / hrs light):

IN-LIFE DATES: From: To:

Administration / exposure

Type of coverage:

not specified

Vehicle:

not specified

Details on dermal exposure:

Subcutaneous

Duration of exposure:

48 hrs

Doses:

1, 2, 4, 6, 8 mL/kg bw

No. of animals per sex per dose:

sex not stated but animal numbers as follows:
5 rats at 1 mL/kg bw,
10 rats at 2, 4 & 6 mL/kg bw,
9 rats at 8 mL/kg bw

Control animals:

no

Results and discussion

Effect levels

Sex:

not specified

Dose descriptor:

LD50

Effect level:

6 mL/kg bw

Based on:

test mat.

Mortality:

0% at 1 mL/kg bw
10% at 2 mL/kg bw
20% at 4 mL/kg bw
50% at 6 mL/kg bw
100% at 8 mL/kg bw

Clinical signs:

other: Ataxia with an initial increase in respiration followed by a decrease. Some central nervous system depression, coma and death.

Gross pathology:

Grossly, the organs of all the animals used, and dying within forty-eight hours, appeared normal. With the highest doses hemolysis and hemoglobinuria were observed.

Applicant's summary and conclusion

Interpretation of results:

practically nontoxic

Remarks:

Migrated information Criteria used for interpretation of results: expert judgment

Conclusions:

The LD50 for subcutaneous administration of diethylene glycol diethyl ether to white rats was 6 mL per kg bw

Executive summary:

DEGDEE and DEGEE, which is in the above study tested for its acute dermal toxicity in rats, are both part of the diethylene glycol monoalkyl and dialkyl ethers category described and evaluated in the document titled "Category Approach-Read across Bis(2 -ethoxyethyl)ether" (2013).

These substances have been demonstrated to be very similar in structure, physical/chemical properties and toxicological profile . Therefore, a read-across from DEGDEE to data obtained with DEGEE is scientifically justified.