Registration Dossier
Registration Dossier
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EC number: 254-075-1 | CAS number: 38668-48-3
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study was performed prior to the implementation of GLP and OECD Guidelines, but meets the principles of an acute inhalation toxicity study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Deviations:
- not applicable
- Principles of method if other than guideline:
- 8h inhalation exposure to a saturated test item atmosphere
according to Smyth et al.: Am. Ind. Hyg. Ass. J., 23, 95-107 (1944) - GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 1,1'-(p-tolylimino)dipropan-2-ol
- EC Number:
- 254-075-1
- EC Name:
- 1,1'-(p-tolylimino)dipropan-2-ol
- Cas Number:
- 38668-48-3
- Molecular formula:
- C13H21NO2
- IUPAC Name:
- 1,1'-(p-tolylimino)dipropan-2-ol
- Details on test material:
- Name of the test substance used in the study report: Diisopropanol-p-toluidin
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- mean body weight at study start: 203 g
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- Two groups of 3 rats per sex were exposed sequentially to the vapors, generated by bubbling 200 l/h air through a substance column of about 5 cm above a fritted glass disc in a glass cylinder for 8 hours.
- Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 8 h
- Concentrations:
- saturated atmophere at 20°C
- No. of animals per sex per dose:
- 3 rats (total of 12 rats tested in two subsequent experiments)
- Control animals:
- no
- Details on study design:
- - Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
- observation period: 7 days
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- other: saturated atmosphere
- Based on:
- test mat.
- Exp. duration:
- 8 h
- Mortality:
- none
- Clinical signs:
- other: no abnormality detected
- Gross pathology:
- no abnormality detected
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
