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Diss Factsheets

Physical & Chemical properties

Solubility in organic solvents / fat solubility

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2012
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Study performed similar to OECD 105, good documentation
Qualifier:
equivalent or similar to guideline
Guideline:
other: OECD 105
Principles of method if other than guideline:
Octanol was used instead of water
GLP compliance:
no
Medium:
n-octanol
Solubility:
> 500 g/L
Temp.:
20 °C
Test substance stable:
yes

In a preliminary study different amounts of test item were mixed with 5 mL octanol. The obtained solution was clear until a gel was formed. With increasing amount of test item added, the solution became more gel like. When 10.1 of the test item were mixed with 5 mL octanol, a gel with a total weight of about 14.2 g was formed (10.1 g test item and 4.1 g n-Octanol). The final density of the gel is about 710 g/L. Due to the fact that the formation of the gel is a continuous process no discrete point can be identified at which the solution switches to gelling, the octanol solubility can be reported as > 500 g/L.

Executive summary:

In the non GLP Klimisch 1 key study from Frischmann (2012), the n-octanol solubility of Sulfosuccinic (ISOFA C10)DiE, Na was determined according to OECD 105 with the exception that n-octanol instead of water was used.

The octanol solubility of Sulfosuccinic (isoFA C10)diE, Na is greater than 500 g/L.Sulfosuccinic (isoFA C10)diE, Na is miscible with octanol in any proportion. With increasing amount of test item a gel is formed.

The results of this study are considered relevant and reliable for the risk assessment.

Description of key information

Solubility in n-octanol (20°C): > 500 g/L

Key value for chemical safety assessment

Additional information

In the non GLP Klimisch 1 key study from Frischmann (2012), the n-octanol solubility of Sulfosuccinic (ISOFA C10)DiE, Na was determined according to OECD 105 with the exception that n-octanol instead of water was used.

The octanol solubility of Sulfosuccinic (isoFA C10)diE, Na is greater than 500 g/L.Sulfosuccinic (isoFA C10)diE, Na is miscible with octanol in any proportion. With increasing amount of test item a gel is formed.

The results of this study are considered relevant and reliable for the risk assessment.