Registration Dossier
Registration Dossier
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EC number: 239-556-6 | CAS number: 15520-10-2
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- No data
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Secondary literature (evaluation and comparison of available data on alipathic amines)
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicity of aliphatic amines: structure-activity relationship
- Author:
- Greim H, Bury D, Klimisch H J, Oeben-Negele M, Ziegler-Skylakakis K
- Year:
- 1 998
- Bibliographic source:
- Chemosphere, Volume 36, Issue 2, Pages 271–295
Materials and methods
Test material
- Reference substance name:
- aliphatic amines
- IUPAC Name:
- aliphatic amines
- Details on test material:
- Various aliphatic amines (17 primary, 11 secondary and 9 tertiary amines).
Constituent 1
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- After intravenous application of primary aliphatic amines, they were detected in the lung, liver, kidney, heart, spleen and brain. Metabolism found included oxidization via monoamine oxidase to aldehydes, followed by metabolic conversion to carboxylic acids via dehydration. Furthermore beta-oxidation was observed resulting in excretion of CO2. Monoamine oxidase selective binding was reduced with increasing chain length of the amines. Moreover the excretion via CO2 was found to be dependent on the chain lenght, too. Primary amines with C6 were shown to have the highest elimination rate via CO2. The rate diminishes with alterations in chain length (increasing as well as decreasing; <
>>). Some amines are excreted mostly unmetabolised in the urine (e.g. ethylamine or diethylamin).
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