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Toxicological information

Genetic toxicity: in vitro

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Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Remarks:
Type of genotoxicity: gene mutation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
review article or handbook
Title:
Unnamed
Year:
1998

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 471 (Bacterial Reverse Mutation Assay)
GLP compliance:
not specified
Type of assay:
bacterial reverse mutation assay

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: crystalline

Method

Species / strain
Species / strain / cell type:
other: TA97a, TA98, TA100 and TA102
Metabolic activation:
with and without
Test concentrations with justification for top dose:
0, 50, 100, 250, 500, 750, 1000, 1250, 1500, 2000, 2500 μg/plate
Vehicle / solvent:
ethanol

Results and discussion

Test results
Species / strain:
other: TA102, TA100, TA98 and TA97a
Metabolic activation:
with and without
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
not specified

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information):
negative

In conclusion, results from the present study thus suggest that citral, citronellal, (±)-camphor, (-).-menthol and 1,8-cineole are not mutagenic in the
Ames test and that terpineol is weakly mutagenic to TA102 tester strain.