Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-157-7 | CAS number: 52-89-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1.8 mg/m³
- Most sensitive endpoint:
- carcinogenicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 12.5
- Dose descriptor starting point:
- NOAEL
- Value:
- 13 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 23 mg/m³
- Explanation for the modification of the dose descriptor starting point:
A fully reliable toxicity study is available for oral route of administration (carcinogenicity study, Kitahori et al. 1997). In this study groups of 50 male and 50 female rats were exposed to levels of 0, 0.25 % and 0.5 % L-Cysteine hydrochloride (0, 133 and 235 mg/kg bw. for males and 0, 148 and 180 mg /
kg bw. for females) in the drinking water for 108 weeks. Although no no-effect level was identified, the clear decline of toxic effects between the 2 dosages allows the estimation that a level of at least 13 mg/kg bw /day for both sexes should be a no-effect level. Even if an inhalative exposure may occur the most suitable way to determine the systemic toxicity of a solid test substance is normally the oral
administration. Additionally the experiences with inhalative administration of dusts of solid substances, i.e. drugs, to humans revealed that such an inhalative exposure leads to a mainly oral ingestion of
the substances. This is especially true for L-Cysteine hydrochloride as (1) the substance has a very low vapour pressure and (2) as the measurement of the particle size distribution revealed, that the mean particle size (of the marketed monohydrate form) is relatively high with no particles < 3 µm which otherwise represent the respirable fraction. In consequence an inhalative exposure will result in an oral uptake of nearly 100 % of the administered dosage. The dose descriptor starting point was derived as follows: NOAEL of 13 mg/kg bw. x 1/0.38 m3/kg/bw x 6.7 m3 / 10 m3 /person = 23 mg/m3 (according to REACH ECHA GD, Example R. 8-2 Workers (Chapter R.8: Characterisation of dose [concentration]-response for human health).- AF for dose response relationship:
- 1
- Justification:
- Derived no-effect level from a carcinogenicity study (see details above)
- AF for differences in duration of exposure:
- 1
- Justification:
- DNEL based on a fully reliable carcinogenicity study (with oral administration of the test article to rats), which is regarded as chronic study. Therefore no AF for differences in duration to be applied.
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- According to ECHA guidance no assessment factor used for inhalation route
- AF for other interspecies differences:
- 2.5
- Justification:
- Remaining differences
- AF for intraspecies differences:
- 5
- Justification:
- Standard factor according to ECHA REACH guidance
- AF for the quality of the whole database:
- 1
- Justification:
- A fully reliable study is used for the derivation of the hazard via oral route
- AF for remaining uncertainties:
- 1
- Justification:
- A fully reliable study is used for the derivation of the hazard via oral route
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 282 mg/m³
- Most sensitive endpoint:
- acute toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 12.5
- Dose descriptor starting point:
- other: LD50
- Value:
- 2 000 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 3 526 mg/m³
- Explanation for the modification of the dose descriptor starting point:
The Dose descriptor starting point was derived as follows: LD50 > 2000 mg/kg bw. x 1/0.38 m3/kg/bw x 6.7 m3 / 10 m3 /person =3526 mg/m3 (according to REACH ECHA GD, Example R. 8-2 Workers (Chapter R.8: Characterisation of dose [concentration]-response for human health).
- AF for dose response relationship:
- 1
- Justification:
- No higher factor applicable because no effects were observed up to the highest dose.
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- AF not used for inhalation route
- AF for other interspecies differences:
- 2.5
- Justification:
- Remaining differences
- AF for intraspecies differences:
- 5
- Justification:
- Standard factor for worker according to ECHA REACH guidance
- AF for the quality of the whole database:
- 1
- Justification:
- A fully reliable acute oral toxicity study is availiable
- AF for remaining uncertainties:
- 1
- Justification:
- AF based on a fully reliable acute oral toxicity study with rats.
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
- Most sensitive endpoint:
- skin irritation/corrosion
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
- Most sensitive endpoint:
- skin irritation/corrosion
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.26 mg/kg bw/day
- Most sensitive endpoint:
- carcinogenicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 50
- Dose descriptor starting point:
- NOAEL
- Value:
- 13 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 13 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
A fully reliable carcinogenicity study with rats is available for the oral route of administration (carcinogenicity study, Kitahori et al. 1997). Appropriate species and dosages were used in this study.
Although no no-effect level was identified, the clear decline of toxic effects between the 2 dosages allows the estimation that a level of at least 13 mg/kg bw /day for both sexes should be a no-effect level. Additionally an acute dermal toxicity study revealed no effects up to and including dosages of 2000 mg/kg bw. It is assumed that the resorption after dermal application is similar to the resorption after oral administration.- AF for dose response relationship:
- 1
- Justification:
- Derived no-effect level from a carcinogenicity study.
- AF for differences in duration of exposure:
- 1
- Justification:
- Derived no-effect level from a carcinogenicity study.
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- According to ECHA guidance a factor of 4 is used for allometric scaling from rat to human.
- AF for other interspecies differences:
- 2.5
- Justification:
- Remaining differences
- AF for intraspecies differences:
- 5
- Justification:
- Standard factor for worker according to ECHA REACH guidance.
- AF for the quality of the whole database:
- 1
- Justification:
- A fully reliable study is available
- AF for remaining uncertainties:
- 1
- Justification:
- A fully reliable study is available
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 40 mg/kg bw/day
- Most sensitive endpoint:
- acute toxicity
- Route of original study:
- Dermal
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 50
- Dose descriptor starting point:
- other: LD50
- Value:
- 2 000 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 2 000 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
no route to route extrapolation necessary
- AF for dose response relationship:
- 1
- Justification:
- No higher factor necessary because no effects were observed up to the highest dose
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- According to ECHA guidance a factor of 4 is used for allometric scaling from rat to human
- AF for other interspecies differences:
- 2.5
- Justification:
- Remaining differences
- AF for intraspecies differences:
- 5
- Justification:
- Standard factor for worker according to ECHA REACH guidance
- AF for the quality of the whole database:
- 1
- Justification:
- A fully reliable study is available
- AF for remaining uncertainties:
- 1
- Justification:
- A fully reliable study is available
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
- Most sensitive endpoint:
- skin irritation/corrosion
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.9 mg/cm²
- Most sensitive endpoint:
- acute toxicity
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 12.5
- Dose descriptor starting point:
- other: LD50
- Value:
- 2 000
- AF for dose response relationship:
- 1
- Justification:
- No higher factor applicable because no effects were observed up to the highest dose
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- AF for allometric scaling of 1, " ... since local effects are independent of the basal metabolic rate,
allometric scaling should not be applied (allometric scaling factor of 1)" (ECHA REACH Guidance C
hapter R8) - AF for other interspecies differences:
- 2.5
- Justification:
- Remaining differences
- AF for intraspecies differences:
- 5
- Justification:
- Standard factor for worker according to ECHA REACH guidance
- AF for the quality of the whole database:
- 1
- Justification:
- AF based on a fully reliable dermal toxicity study with rats
- AF for remaining uncertainties:
- 1
- Justification:
- AF based on a fully reliable dermal toxicity study with rats
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.9 mg/m³
- Most sensitive endpoint:
- carcinogenicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 25
- Dose descriptor starting point:
- NOAEL
- Value:
- 13 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 23 mg/m³
- Explanation for the modification of the dose descriptor starting point:
A fully reliable toxicity study is available for oral route of administration (carcinogenicity study, Kitahori et al. 1997). In this study groups of 50 male and 50 female rats were exposed to levels of 0, 0.25 % and 0.5 % L-Cysteine hydrochloride (0, 133 and 235 mg/kg bw. for males and 0, 148 and 180 mg /kg bw. for females) in the drinking water for 108 weeks. Although no no-effect level was identified, the clear decline of toxic effects between the 2 dosages allows the estimation that a level of at least 13 mg/kg bw /day for both sexes should be a no-effect level. Even if an inhalative exposure may occur the most suitable way to determine the systemic toxicity of a solid test substance is normally the oral administration. Additionally the experiences with inhalative administration of dusts of solid substances, i.e. drugs, to humans revealed that such an inhalative exposure leads to a mainly oral ingestion of the substances. This is especially true for L-Cysteine hydrochloride as (1) the substance has a very low vapour pressure and (2) as the measurement of the particle size distribution revealed, that the mean particle size (of the marketed monohydrate form) is relatively high with no particles < 3 µm which otherwise represent the respirable fraction. In consequence an inhalative exposure will result in an oral uptake of nearly 100 % of the administered dosage. The dose descriptor starting point was derived as follows: NOAEL of 13 mg/kg bw. x 1/0.38 m3/kg/bw x 6.7 m3 / 10 m3 /person = 23 mg/m3 (according to REACH ECHA GD, Example R. 8-2 Workers (Chapter R.8: Characterisation of dose [concentration]-response for human health).
- AF for dose response relationship:
- 1
- Justification:
- Derived no-effect level from a carcinogenicity study
- AF for differences in duration of exposure:
- 1
- Justification:
- DNEL based on a fully reliable carcinogenicity study with oral administration of the test article to rats.
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- According to ECHA guidance no assessment factor used for inhalation route
- AF for other interspecies differences:
- 2.5
- Justification:
- Remaining differences
- AF for intraspecies differences:
- 10
- Justification:
- Standard factor for the general public according to ECHA REACH guidance
- AF for the quality of the whole database:
- 1
- Justification:
- A fully reliable study is used for the derivation of the hazard via oral route
- AF for remaining uncertainties:
- 1
- Justification:
- A fully reliable study is used for the derivation of the hazard via oral route
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 141 mg/m³
- Most sensitive endpoint:
- acute toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 25
- Dose descriptor starting point:
- other: LD50
- Value:
- 2 000 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 3 526 mg/m³
- Explanation for the modification of the dose descriptor starting point:
The Dose descriptor starting point was derived as follows: LD50 > 2000 mg/kg bw. x 1/0.38 m3/kg/bw x 6.7 m3 / 10 m3 /person =3526 mg/m3 (according to REACH ECHA GD, Example R. 8-2 Workers (Chapter R.8: Characterisation of dose [concentration]-response for human health).
- AF for dose response relationship:
- 1
- Justification:
- No higher factor applicable because no effects were observed up to the highest dose
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- According to ECHA guidance no assessment factor used for inhalation route.
- AF for other interspecies differences:
- 2.5
- Justification:
- Remaining differences
- AF for intraspecies differences:
- 10
- Justification:
- Standard factor for the general public according to ECHA REACH guidance.
- AF for the quality of the whole database:
- 1
- Justification:
- A fully reliable study is used for the derivation of the hazard.
- AF for remaining uncertainties:
- 1
- Justification:
- A fully reliable study is used for the derivation of the hazard.
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
- Most sensitive endpoint:
- skin irritation/corrosion
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
- Most sensitive endpoint:
- skin irritation/corrosion
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.13 mg/kg bw/day
- Most sensitive endpoint:
- carcinogenicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 100
- Dose descriptor starting point:
- NOAEL
- Value:
- 13 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 13 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
A fully reliable carcinogenicity study with rats is available for the oral route of administration (carcinogenicity study, Kitahori et al. 1997). Appropriate species and dosages were used in theis study.
Although no no-effect level was identified, the clear decline of toxic effects between the 2 dosages allows the estimation that a level of at least 13 mg/kg bw /day for both sexes should be a no-effect level. Additionally an acute dermal toxicity study revealed no effects up to and including dosages of 2000 mg/kg bw. It is assumed that the resorption after dermal application is similar to the resorption after oral administration.- AF for dose response relationship:
- 1
- Justification:
- Derived no-effect level from a carcinogenicity study.
- AF for differences in duration of exposure:
- 1
- Justification:
- DNEL based on a fully reliable carcinogenicity study with oral administration of the test article to rats.
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- According to ECHA guidance a factor of 4 is used for allometric scaling from rat to human.
- AF for other interspecies differences:
- 2.5
- Justification:
- Remaining differences
- AF for intraspecies differences:
- 10
- Justification:
- Standard factor for the general public according to ECHA REACH guidance
- AF for the quality of the whole database:
- 1
- Justification:
- A fully reliable study is used for the derivation of the hazard via dermal route
- AF for remaining uncertainties:
- 1
- Justification:
- A fully reliable study is used for the derivation of the hazard via dermal route
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 20 mg/kg bw/day
- Most sensitive endpoint:
- acute toxicity
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 100
- Dose descriptor starting point:
- other: LD50
- Value:
- 2 000 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 2 000 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
no route to route extrapolation necessary
- AF for dose response relationship:
- 1
- Justification:
- No higher factor necessary because no effects were observed up to the highest dose.
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- According to ECHA guidance a factor of 4 is used for allometric scaling from rat to human
- AF for other interspecies differences:
- 2.5
- Justification:
- Remaining differences
- AF for intraspecies differences:
- 10
- Justification:
- Standard factor for the general public according to ECHA REACH guidance
- AF for the quality of the whole database:
- 1
- Justification:
- A fully reliable study is used for the derivation of the hazard via dermal route
- AF for remaining uncertainties:
- 1
- Justification:
- A fully reliable study is used for the derivation of the hazard via dermal route
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
- Most sensitive endpoint:
- skin irritation/corrosion
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.45 mg/cm²
- Most sensitive endpoint:
- acute toxicity
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 25
- Dose descriptor starting point:
- other: LD50
- AF for dose response relationship:
- 1
- Justification:
- No higher factor necessary because no effects were observed up to the highest dose.
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- AF for allometric scaling of 1, " ... since local effects are independent of the basal metabolic rate,
allometric scaling should not be applied (allometric scaling factor of 1)" (ECHA REACH Guidance C
hapter R8) - AF for other interspecies differences:
- 2.5
- Justification:
- Remaining differences
- AF for intraspecies differences:
- 10
- Justification:
- Standard factor for the general public according to ECHA REACH guidance
- AF for the quality of the whole database:
- 1
- Justification:
- AF based on a fully reliable study acute dermal toxicity study with rats
- AF for remaining uncertainties:
- 1
- Justification:
- AF based on a fully reliable study acute dermal toxicity study with rats
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.13 mg/kg bw/day
- Most sensitive endpoint:
- carcinogenicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 100
- Dose descriptor starting point:
- NOAEL
- Value:
- 13 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 13 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
A toxicological study with oral administration is used for extrapolation to the hazard via oral route of the general population. A fully reliable carcinogenicity study with administration in the drinking water to rats is available (Kitahori et al. 1997). Appropriate species and dosages were used in this study. Although no no-effect level was identified, the clear decline of toxic effects between the 2 dosages allows the estimation that a level of at least 13 mg/kg bw /day for both sexes should be a no-effect level.
- AF for dose response relationship:
- 1
- Justification:
- Derived no-effect level from a carcinogenicity study.
- AF for differences in duration of exposure:
- 1
- Justification:
- Derived no-effect level from a carcinogenicity study (= chronic study)
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- According to ECHA guidance a factor of 4 is used for allometric scaling from rat to human.
- AF for other interspecies differences:
- 2.5
- Justification:
- Remaining differences
- AF for intraspecies differences:
- 10
- Justification:
- Standard factor for the general public according to ECHA REACH guidance.
- AF for the quality of the whole database:
- 1
- Justification:
- A fully reliable study is used for the derivation of the hazard via oral route
- AF for remaining uncertainties:
- 1
- Justification:
- no further AF necessary
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 20 mg/kg bw/day
- Most sensitive endpoint:
- acute toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 100
- Dose descriptor starting point:
- other: LD50
- Value:
- 2 000 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 2 000 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
no route to route extrapolation necessary.
- AF for dose response relationship:
- 1
- Justification:
- No effects were observed after oral administration of dosages of 2000 mg/kg bw. to rats
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- According to ECHA guidance a factor of 4 is used for allometric scaling from rat to human.
- AF for other interspecies differences:
- 2.5
- Justification:
- Remaining differences
- AF for intraspecies differences:
- 10
- Justification:
- Standard factor for the general public according to ECHA REACH guidance.
- AF for the quality of the whole database:
- 1
- Justification:
- A fully reliable acute oral toxicity study is used for the derivation of the hazard via oral route
- AF for remaining uncertainties:
- 1
- Justification:
- A fully reliable acute oral toxicity study is used for the derivation of the hazard via oral route
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
An in vitro study was performed to assess the corneal irritation and damage potential of L-Cysteine Hydrochloride Monohydrat. Bovine corneas were incubated for 4 hours with a 20% solution of the test item in 0.9% NaCl solution. Afterwards the change of opacity was measured and compared to negative and positive control groups. The changes in opacity of the control groups, 0.402 and 80.746, met the validity criteria.
L-Cysteine Hydrochloride Monohydrat caused a change in opacity of 9.815.
According to OECD 437 L-Cysteine Hydrochloride Monohydrat is classified as "non corrosive" and/or "no severe irritant".
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.