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Vapour pressure

Link to relevant study record(s)

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

from 11 OCT 2007 to 5 DEC 2007

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Deviations:

no

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

gas saturation method

Temp.:

25 °C

Vapour pressure:

11 Pa

Remarks on result:

other: measured

Key result

Temp.:

25 °C

Vapour pressure:

10 Pa

Remarks on result:

other: calculated

Temp.:

20 °C

Vapour pressure:

6.3 Pa

Remarks on result:

other: calculated

Temp.:

15 °C

Vapour pressure:

4.1 Pa

Remarks on result:

other: measured

Temp.:

5 °C

Vapour pressure:

1.3 Pa

Remarks on result:

other: measured

The experiments were performed at 25 °C, 15 °C and 5 °C. To ensure saturation control, three different flow rates were used at each temperature.

The experimental results lead to the conclusion that the vapor pressure of the test item DIMETHYL 2-METHYL GLUTARATE is:

11 Pa at 25 °C

4.1 Pa at 15 °C

1.3 Pa at 5 °C

The trapping efficiency of the test item DIMETHYL 2-METHYL GLUTARATE in the first cooling trap was very good. Between 96% and 100% of the test item was trapped in the first cooling trap.

Table 1: Results of the vapor pressure determination of DIMETHYL 2-METHYL GLUTARATE / Trapping efficiency of DIMETHYL 2-METHYL GLUTARATE

 

Column N°.	Temp. (°C)	Volume* V2 (mL)	Amount of the test item in trap 1 (µg)	Amount of test item in trap 2 (µg)	Total amount of test item (µg)	Vapor pressure (Pa)	Average vapor pressure (Pa)	Trapping effeciency 1^sttrap (%)
1 2 3	25.6	2820 3381 3781	2137.248 2569.199 2895.697	5.052 9.278 12.330	2142.300 2578.476 2908.027	11 11 11	11	99.76 99.64 99.58
1 2 3	15.45	2801 3408 3870	818.706 1011.861 1125.855	9.328 7.482 11.199	828.034 1019.342 1137.054	4.1 4.1 4.0	4.1	98.87 99.27 99.02
1 2 3	5.1	4307 5154 5857	427.225 458.720 583.651	16.497 7.638 10.408	443.722 466.358 594.058	1.4 1.2 1.3	1.3	96.28 98.36 98.25

 

* corrected volume at test temperature as calculated under “volume correction”

The vapor pressure of DIMETHYL 2-METHYL GLUTARATE at 25 °C and 20 °C were calculated by interpolation from the vapor pressure curve and were calculated to be 10 Pa at 25 °C and 6.3 at 20 °C.

Table 2: Data of the vapor pressure curve for DIMETHYL 2-METHYL GLUTARATE

 

T (°C)	1/T (Kelvin)	Ln Pvp
25.6	0.00335 0.00335 0.00335	2.38 2.39 2.40
15.45	0.00347 0.00347 0.00347	1.40 1.42 1.40
5.1	0.00359 0.00359 0.00359	0.31 0.18 0.30

The tabulated results represent rounded-off values obtained by calculations based on the exact

raw data.

Y = b * x + a with Y = ln (Pvp mean in Pa)

x = 1/T (Kelvin)

b = -8612.104 (slope)

a = 31.23 (y-axis intercept)

r2 = 0.9982

Conclusions:

The vapor pressure of DIMETHYL 2-METHYL GLUTARATE was measured at test temperatures of 25 °C, 15 °C and 5 °C and was determined to be 11 Pa at 25 °C, 4.1 Pa at 15 °C, 1.3 Pa at 5 °C.
The vapor pressure of DIMETHYL 2-METHYL GLUTARATE at 25 °C and 20 °C were interpolated from the vapor pressure curve and were calculated to be 10 Pa at 25 °C and 6.3 Pa at 20 °C.

Executive summary:

The vapor pressure of DIMETHYL 2-METHYL GLUTARATE was determined according to the EEC Directive 92/69, A.4 ”Vapour Pressure” (1992) and the OECD guideline No. 104, ”Vapour Pressure” (1995) using the gas saturation method.

The vapor pressure of DIMETHYL 2-METHYL GLUTARATE was measured at test temperatures of 25 °C, 15 °C and 5 °C and was determined to be 11 Pa at 25 °C, 4.1 Pa at 15 °C, 1.3 Pa at 5 °C.

The vapor pressure of DIMETHYL 2-METHYL GLUTARATE at 25 °C and 20 °C were interpolated from the vapor pressure curve and were calculated to be 10 Pa at 25 °C and 6.3 Pa at 20 °C.

Description of key information

The vapor pressure of DIMETHYL 2-METHYL GLUTARATE was measured at test temperatures of 25 °C, 15 °C and 5 °C and was determined to be 11 Pa at 25 °C, 4.1 Pa at 15 °C, 1.3 Pa at 5 °C.

The vapor pressure of DIMETHYL 2-METHYL GLUTARATE at 25 °C and 20 °C were interpolated from the vapor pressure curve and were calculated to be 10 Pa at 25 °C and 6.3 Pa at 20 °C.

Key value for chemical safety assessment

Vapour pressure:

10 Pa

at the temperature of:

25 °C

Additional information

One experimental study, scored as Klimisch 1, is available (Badt-Tognucci A., 2007) and selected as a key study.