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EC number: -
CAS number: -
The effects of the FeNa-EDDHMA on survival
and reproductive Performance in Daphnia magna during 21 days of exposure
were investigated in an OECD guideline No. 211 "Daphnia magna
The nominal concentrations tested were 10,
32, 100, 320 and 1000 mg/L. Duration of the study was 21 days and the
test solutions were renewed three times a week. 10 neonate daphnia for
the test concentrations and 20 neonate daphnia for the control group
were investigated. At the start of the test and every workday, the
condition of the parental daphnia was recorded and during the
reproduction phase the number of living offspring, immobile young and
the presence of unhatched eggs were recorded. During the study duplicate
samples of 10 ml were taken from freshly prepared solutions on days 0,
7, 14 and 19, from 72-hour old solutions on day 3 and from 48-hour old
solutions on day 21. Samples were stored in a deep-freeze until possible
Analysis of the samples showed that the
method of preparation of test media provided repeatable recoveries of
test substance concentration. Measured concentrations were all in
agreement with nominal, except for those measured in the samples taken
at 1000 mg/L (85% - 89%) during the 2 -day period after the last
renewal. Further, the measured concentrations were stable during the
periods between renewals of the test solutions.
No mortality or other visible effects were
recorded for the parental organisms at any of the test item
concentrations tested.During the total exposure period of 21 days, no
significant (greater than 10%) immobilisation (including mortality) of
newborn young was observed at any of the test concentrations.
In conclusion the FeNa-EDDHMA had no effect
on the survival of Daphnia magna at concentrations up to and including
1000 mg/L in this reproduction study. The test item affected the
reproductive capacity of Daphnia magna at concentrations of 320 and 1000
mg/L. A biologically relevant effect on reproductive capacity of Daphnia
magna was noted at 1000 mg/L.
Based on the structural similarity, the
similar physico-chemical properties and the similar toxicity to aquatic
invertebrates and algae between FeNa-EDDHMA and MEAHA-Fe, identical
conclusions are drawn for the read-across target MEAHA-Fe.
Read across to structural analogue FeNa-EDDHMA.
In this long-term study FeNa-EDDHMA had no effect on the survival of
Daphnia magna at concentrations up to and including 1000 mg/L. A NOEC of
320 mg/L was derived based on reproduction and greater than or equal to
1000 mg/L based on parental mortality.
Read across to structural analogue
FeEDDHMANa. For justification of read across see IUCLID section 13.
The acute toxicity to Daphnia magna
was performed according to OECD guideline 211. An EC50 of 628
mg/L based on reproduction and an EC50 of greater than 1000 mg/L based
on parental mortality was detected. The animals were exposed to
FeNa-EDDHMA for 21 days in a static test system (Akzo Nobel Chemicals
B.V., 1996). A NOEC of 320 mg/L was derived based on reproduction and
greater than or equal to 1000 mg/L based on parental mortality.
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