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EC number: 701-029-8
CAS number: -
- All rats exposed to 0 (air) and 9.2 mg MDI/m3 tolerated the whole-body
exposure without specific signs whilst the 118 and 110 mg MDI/m3-exposed
rats experienced labored and irregular breathing patterns, bradypnea and
a serous nasal discharge. Mortality did not occur in any group. Apart
from the 'irregular breathing pattern' both the incidence and intensity
of clinical findings were almost identical in whole-body and nose-only
exposed rats. The signs observed were related to respiratory tract
- Comparisons of control and MDI-exposed rats did not reveal any
statistically significant effect on body weights, though there was a
tendency of slightly decreased body weight gains in nose-only exposed
- Statistical analysis of measurements of rectal temperatures revealed a
significant hypothermia in the nose-only exposed rats.
- in nose-only exposed rats, lung weights were increased to a greater
extent than in the in whole-body exposed rats. These findings are taken
as indirect evidence that the nose-only mode of exposure provides a more
rigorous means the expose rats to MDI. In whole-body exposed rats
measures were taken to prevent their huddling together or burying their
noses into the fur of neighboring rats in order to minimize their
exposure to irritant particulates. Nonetheless, the irritant-related,
reflexively induced hypothermia, associated with elevated lung weights ,
was only discernible in nose-only exposed rats.
- At no time point was there evidence of any effect on the frequency of
mast cells. The frequency of mast cells was low enough not to interfere
with the outcome of test. Rats treated with the positive control
substances displayed increased MN-PCE on sampling days 1 and 2, but not
on day 7. At no time point there was any evidence of an effect on the
frequency of MN-PCE in MDI-exposed animals. -No differences in outcome
existed following staining with the DANN-specific Acridine -Orange or
Wright-Giemsa. These results indicate that, under the experimental
conditions used, aerosolized MDI did not induce cytogenetic damage in
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