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EC number: 701-029-8
CAS number: -
test substance is covered by the category approach of methylenediphenyl
diisocyanates (MDI). Hence, data of the category substances can be used
to cover this endpoint. The read-across category justification document
is attached in IUCLID section 13. It is important to note that the MDI
category approach for read-across of environmental and human hazards
between the MDI substances belonging to the MDI category is work in
progress under REACH. Therefore the read-across document should be
considered a draft.
Due to the high reactivity of the substances of the MDI category with
water, bioaccumulation tests can in principle not be performed with
these substances. However, one bioaccumulation test (OECD 305E) with
4,4'-MDI and a mesocosm study with PMDI with an indication of
bioaccumulation potential have been performed.
No data are available on terrestrial bioaccumulation on any of the MDIs
of the category approach. The reactivity of MDI with water, the low
measured BCF in fish and the evidence of the mesocosm study, suggest
that MDI has a low potential to bioaccumulate in terrestrial food-chains.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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