Registration Dossier
Registration Dossier
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EC number: 701-266-7 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Limited skin and eye irritation data are available with Polyethylene polyamine, pentaethylenehexamine fraction. However, the main consitutent- linear PEHA (CAS 4067-16-7)- is harmonised classified as corrosive. Furthermore, the registration substance is described to have a pH of 12.6. Therefore, the registration substance is also classified as corrosive and no further testing is required.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irreversible damage)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
There are only limited data on skin and eye irritation/corrosion of Polyethylene polyamine, pentaethylenehexamine fraction available. The substance is described to have an pH of 12.6 therefore no further testing is required according to the standard information requirements set out in Annex VII-VIII, 8.1 and 8.2 of Regulation (EC) No 1907/2006. Furthermore, the main constituent linear PEHA (CAS 4067 -16 -7) is harmonised classified as corrosive.
Skin irritation/corrosion:
A limited skin irritation test with Polyethylene polyamine, pentaethylenehexamine fraction is available performed before OECD guidelines and GLP were in place (Olson, 1963). Skin corrosion potential for the test substance was observed.
Eye irritation
A limited skin irritation test with Polyethylene polyamine, pentaethylenehexamine fraction is available performed before OECD guidelines and GLP were in place (Olson, 1963). Eye damage potential for the test substance was observed.
Based on the results of the skin and eye irritation/corrosion studies with the registration substance itself and the information on pH and the main constituent sufficient evidence is available to conclude that the registered substance Polyethylene polyamine, pentaethylenehexamine fraction is also corrosive to skin and eye.
Justification for classification or non-classification
A harmonised classification for skin irritation for linear PEHA (CAS 4067 -16 -7) is available (Skin Corr. Category 1B, H314) which is the main constituent of the registered substance. The pH of the registered substance is 12.6. Therefore, the registered substance meets the criteria for classification according to Regulation (EC) No. 1272/2008. The test substance is therefore classified as corrosive to skin Cat. 1B (H314) and damaging to eyes Cat. 1 (H318).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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