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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
26 September 2015 - 21 January 2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
Qualifier:
according to
Guideline:
EPA OPPTS 830.7950 (Vapor Pressure)
Deviations:
no
GLP compliance:
yes
Type of method:
effusion method: isothermal thermogravimetry
Specific details on test material used for the study:
Batch M14KB4863
Test item storage conditions: At room temperature
Stable under storage conditions until 10 November 2017 (retest date)
Key result
Temp.:
20 °C
Vapour pressure:
<= 0 Pa
Key result
Temp.:
25 °C
Vapour pressure:
<= 0 Pa

Reference substances

Validation of the method is performed at least once every year (WIL project 512159). Each reference substance was measured in duplicate by TGA using a temperature program that was specific for the substance. Plots of log vT obtained at elevated temperatures and 1/T were inter- or extrapolated to determine the log vTvalues at 20°C (log vT,20). The log vT,20values were plotted against the logarithm of the vapour pressure at 20°C in Pascal units (log PT,20). Linear regression analysis using the least squares method yielded an equation of log PT,20= 1.14 log vT,20+ 4.55. The coefficient of correlation (r) was > 0.99. The constants c and d specific for the experimental arrangement were 1.14 and 4.55, respectively.

Results

Isothermal TGA analysis: from the plot of the log PT of the test item as a function of the reciprocal temperature the equation of the curve could be derived: log PT= -5803 x 1/T + 14.68 (r = 0.998, n = 8). The results for the vapour pressure of the test item at 20°C and 25°C is:

 Temperature (°C)  log PT  PT (Pa)  PT (mm Hg)
 20  -5.12  7.6 E-6  5.7 E-8
 25  -4.79  1.6 E-5  1.2 E-7

 

 

 

Conclusions:
The isothermal TGA effusion method was applied for the determination of the vapour pressure of JNJ-39453193-AAA (T003063).
The vapour pressure of the test item was <= 7.6 E-6 Pa (or <= 5.7 E-8 mm Hg) at 20°C (293K) and <= 1.6 E-5 Pa (or <= 1.2 E-7 mm Hg) at 25°C (298K).

Description of key information

The vapour pressure of T003063 was assessed using the isothermal TGA effusion method according to the guidelines OECD 104, EU method A.4 and EPA OPPTS 830.7950 (Klimisch 1, Brekelmans, 2016).

In this study, the vapour pressure of the test item was <= 7.6 E-6 Pa (or <= 5.7 E-8 mmHg) at 20°C (293K) and <= 1.6 E-5 Pa (or <= 1.2 E-7 mmHg) at 25°C (298K).

Key value for chemical safety assessment

Vapour pressure:
0 Pa
at the temperature of:
20 °C

Additional information