Registration Dossier

Administrative data

Endpoint:
acute toxicity: inhalation
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
other:
Cross-referenceopen allclose all
Reason / purpose:
data waiving: supporting information
Reference

Vapour pressure was predicted using QSAR models of EPI Suite and US EPA T.E.S.T (US EPA, 2018).

Vapour pressure:
0 Pa
at the temperature of:
25 °C

Predicted VP from MPBPWIN v.1.44 of EPiSuite v.4.11: VP range: 3.89E-26 to 2.84E-06 Pa at 25°C; weighted average: 1.55E-06 Pa at 25°C. di-TMPTTA predictions at higher temperatures: 5.25E-04 Pa at 60°C; 1.88 E-03 Pa at 70°C

Predicted VP from US EPA T.E.S.T v.4.2.1: VP range: 2.95E-09 to 1.33E-01 Pa at 25°C; weighted average: 2.96E-03 Pa at 25°C.

Based on the individual or weighted average VP predictions from EPISuite and T.E.S.T, the test substance is overall considered to have low volatility. The individual prediction for the most volatile constituent, di-TMPTTA, which is also the major constituent of the test substance present at 20-70%, has been considered, to represent the worst case scenario. However, given that the test substance has operating conditions at higher temperatures (such as 60 and 70°C), and that the T.E.S.T QSAR model only allows prediction at 25°C, the individual VP predictions for di-TMPTTA at 25°C and higher temperatures from EPISuite, has been considered further for risk assessment.

Reason / purpose:
data waiving: supporting information
Reference
Endpoint:
appearance / physical state / colour
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Safety Data Sheet
Qualifier:
no guideline followed
GLP compliance:
no
Physical state at 20°C and 1013 hPa:
liquid
Colour:
Colorless to pale yellow
Odour:
other: ester acrylate
Substance type:
organic
Conclusions:
The substance is a colourless to pale yellow liquid with an ester acrylate odour.
Executive summary:

The substance is a colourless to pale yellow liquid with an ester acrylate odour.

Data source

Materials and methods

Results and discussion

Applicant's summary and conclusion