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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
25 Feb - 07 Mar 2014
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2014
Report date:
2014

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Version / remarks:
May 31, 2008
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Version / remarks:
July 27, 1995
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7840 (Water Solubility)
Version / remarks:
March 1998
Deviations:
no
GLP compliance:
yes
Type of method:
flask method

Test material

Constituent 1
Chemical structure
Reference substance name:
2-chloro-7-cyclopentyl-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
Cas Number:
1211443-61-6
Molecular formula:
C14 H17 Cl N4 O
IUPAC Name:
2-chloro-7-cyclopentyl-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide

Results and discussion

Water solubility
Water solubility:
0.572 g/L
Temp.:
20 °C
pH:
>= 6.4 - <= 6.9

Any other information on results incl. tables

Main study - water solubility of the test substance

Stirring time [hours]

Analysed concentration [g/L]

Mean [g/L]

MD [%]

pH

24

0.611

0.572

11

6.9

48

0.559

 

 

6.8

72

0.545

 

 

6.4

 

The maximum difference (MD) of the concentrations determined in the 24, 48 and 72 hour test samples was ≤ 15%. Based on this, the water solubility of the test substance is given as the mean value of the analysed concentrations.

A small response at the retention time was observed in the blank water mixture. The content was maximum 0.0014% to the water solubility of the test substance. It was considered that the response had no significant effect on the outcome of the test.

 

Conclusion

The water solubility of the test substance at 20 °C was 0.572 g/L.

The pH of the aqueous samples was 6.4-6.9.

Applicant's summary and conclusion

Conclusions:
The solubility in water of the test substance was measured to be 0.572 g/L at 20 °C, pH 6.4-6.9