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EC number: 260-742-8 | CAS number: 57453-97-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Description of key information
No toxicity data on adverse effects on sexual function and fertility with magnesium neodecanoate are available, thus the reproductive toxicity will be addressed with existing data on the individual moieties magnesium and neodecanoic acid.
Magnesium neodecanoate is not expected to impair sexual function or fertility, since the two moieties magnesium and neodecanoate have not shown respective adverse effects.
Effect on fertility: via oral route
- Endpoint conclusion:
- no adverse effect observed
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Additional information
No toxicity data on adverse effects on sexual function and fertility with magnesium neodecanoate are available, thus the reproductive toxicity will be addressed with existing data on the individual moieties magnesium and neodecanoic acid.
Magnesium
Magnesium is of great importance in human fertility and development. The scientific evidence was taken into account by the Scientific Committee on Food which concluded that magnesium lacks effects on the reproductive function in humans. Also, magnesium is necessary for DNA replication and bone development during pregnancy, demonstrating the pivotal role of magnesium in human fertility in man and women. It is therefore concluded that magnesium itself does not show any developmental toxicity effects. Additional studies in animals are not believed to contribute to the existing evidence for a lack developmental toxicity of magnesium.
Neodecanoic acid
In a modified three-generation reproductive toxicity study, male and female Sprague-Dawley rats were administered neodecanoic acid at 0, 100, 500 and 1500 ppm (approximately 0, 5, 25 and 75 mg/kg-bw/day, respectively) in the diet. No adverse effects were observed on survival, appearance, behaviour, body-weight gain and food consumption in the parental, F1 or F2 generations. The reproductive performance of the parents was not affected. No treatment-related gross or microscopic pathological findings were observed at any of the dietary levels.
Magnesium neodecanoate
As the two moieties of magnesium neodecanoate do not impair sexual function, fertility or the development of the offspring, magnesium neodecanoate in all probability does also not have reproductive toxic effects.
Information on the individual moieties magnesium and neodecanoic acid will be used for the hazard assessment and, when applicable, for the risk characterisation of magnesium neodecanoate.
Effects on developmental toxicity
Description of key information
No toxicity data on adverse effects on sexual function and fertility with magnesium neodecanoate are available, thus the reproductive toxicity will be addressed with existing data on the individual moieties magnesium and neodecanoic acid.
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no adverse effect observed
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Additional information
Magnesium:
According to the overall conclusion on the role of magnesium for human development, magnesium is considered not to impair the development of the offspring, but in contrary is recognised as essential for all aspects of an unimpeded normal reproduction.
Neodecanoate:
In a three generation reproductive toxicity study according to OECD guideline 416 with neodecanoic acid administered in the diet up to and including a dose level of 1500 ppm, the F1 and F2 offspring was free of adverse effects.
Magnesium neodecanoate:
Magnesium neodecanoate is not expected to have adverse effects to the developing embryo or fetus requiring classification, since there are no indications that the two moieties magnesium and neodecanoate have such effects.
Justification for classification or non-classification
As there are no indications that the two moieties of magnesium neodecanoate impair sexual function, fertility or the development of the offspring, magensium neodecanoate in all probability does also not have reproductive toxic effects.
According to the criteria of REGULATION (EC) No 1272/2008 and its subsequent adaptions, magnesium neodecanoate does not have to be classified and has no obligatory labelling requirement for reproductive toxicity.Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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