(10E)-oxacycloheptadec-10-en-2-one

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

1974

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Method equivalent or similar to guideline, non-GLP. Information is sufficient to conclude absence of classifiation and labelling when combined with other available information.

Cross-reference

Reason / purpose for cross-reference:

read-across: supporting information

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1974

Report date:

1974

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

no

GLP compliance:

no

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Oxacycloheptadec-7-en-2-one

EC Number:

231-929-1

EC Name:

Oxacycloheptadec-7-en-2-one

Cas Number:

7779-50-2

Molecular formula:

C16H28O2

IUPAC Name:

oxacycloheptadec-7-en-2-one

Test material form:

liquid

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Details on oral exposure:

MAXIMUM DOSE VOLUME APPLIED: 5000 mg/kg bw

Doses:

5000 mg/kg bw

No. of animals per sex per dose:

Not reported

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: No
- Other examinations performed: clinical signs

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 5 000 mg/kg bw

Based on:

test mat.

Mortality:

No mortality observed.

Clinical signs:

other: No significant effects observed.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Remarks:

EU criteria not met

Conclusions:

Under the conditions of this study, the LD50 (male/female) was determined to be > 5000 mg/kg bw

Executive summary:

The study was performed according to a method equivalent or similar to OECD TG 401 to assess the acute oral toxicity potential of the test item to the rat. Following administration by oral gavage at a dose level of 5000 mg/kg bodyweight there were no mortalities and no significant clinical signs. Under the conditions of this study, the LD50 (male/female) was determined to be > 5000 mg/kg bw.