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EC number: 446-990-1
CAS number: -
Breeding for F1 Litters
Number of females paired
Number of females mated
Number of pregnant females (A)
Number of females which reared their pups until day 4 post partum
Nos. 60 and 69 were not pregnant.
The purpose of this study was to generate
preliminary information concerning the effects of LCE08125 on male and
female reproductive performance such as gonadal function, mating
behavior, conception and parturition.
Four groups of 10 males and 10 females were treated
by gavage with LCE08125 once daily. Males were treated over a 14-day
pre-pairing period and during the pairing period up to one day before
necropsy. Females were treated throughout the pre-pairing, pairing,
gestation and lactation period up to day 3 post partum.
The following dose levels were used:
Group 1: 0 mg/kg body weight/day
Group 2 100 mg/kg body weight/day
Group 3: 300 mg/kg body weight/day
Group 4 1000 mg/kg body weight/day
A standard dose volume of 10 mL/kg body weight with
a daily adjustment to the actual body weight was used. Control animals
were dosed with the vehicle alone (highly purified water).
All animals survived until the scheduled necropsy
and no clinical signs were observed during the entire study.
Food Consumption and Body Weights
In males and females, mean food consumption, mean
body weight and mean body weight gains were not adversely affected by
the treatment with the test item for the whole duration of the treatment.
Relevant reproduction data (mean number of corpora
lutea, mean number of implantations per dam, and the post-implantation
losses) were not affected by treatment with the test item. The mean
duration of gestation was similar in all groups.
Mean weight of testes and epididymides were not
affected by treatment with the test item.
No test item-related effects were noted in
reproductive organs in high-dose animals.
Mean litter size at first litter check and on day 4
post partum was not affected by treatment with the test item. Mean pup
weights and weight gains were also not affected.
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