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EC number: 446-990-1
CAS number: -
The study was performed to assess the acute dermal toxicity of the test
material in the Sprague-Dawley CD strain rat. The method was designed to
meet the requirements of the following: OECD Guidelines for the
Testing of Chemicals No. 402 “Acute Dermal Toxicity” (adopted 24
February 1987) Method B3 Acute Toxicity (Dermal) of Commission
A group of ten animals (five males and five females) was given a single,
24-hour, semi-occluded dermal application of the test material to intact
skin at a dose level of 2000 mg/kg bodyweight.
Clinical signs and bodyweight development were monitored during the
study. All animals were subjected to gross necropsy.
Mortality. There were no deaths. Clinical Observations. There were no
signs of systemic toxicity.
Dermal Irritation. There were no signs of dermal irritation.
Bodyweight. All animals showed expected gains in bodyweight over the
study period. Necropsy. No abnormalities were noted at necropsy.
Conclusion. The acute dermal median lethal dose (LD50) and the maximum
sub-lethal dose (LD0) of the test material in the Sprague-Dawley CD
strain rat were found to be greater than 2000 mg/kg bodyweight.
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