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EC number: 446-990-1
CAS number: -
2 acute oral and dermal toxicity studies were performed. No mortality was observed.LD50 oral and dermal routes > 2000 mg/kg bw/d
The product LCA 01006 was administrated to a group of 10 Sprague-Dawley
rats (5 males and 5 females) at the single dose of 2000 mg/kg body
weight according to the experimental protocol established on the basis
of the official method as defined in the OECD guideline n°401 dated
February 24th, 1987 and the test method B.1 of the Directive n°92/69/EEC
dated December 29th, 1992.
No mortality occured during the study.
No clinical signs related ti the administration of the test ptoduct were
observed. The body weight evolution of the animals remained normal
throughout the study, similar between treated and control animals.
The macrsocopical examintaion of the animals at the end of the study did
not reveal treatment related changes.
In conclusion, the LD50 of the product LCA 01006 is higher than 2000
mg/kg body weight by oral route in the rat.
According to the criteria for classification, packaging and labelling of
dangerous substances in accordance with EEC directives 67/548 and 93/21,
the product LCA 01006 must not be classified.
The study was performed to assess the acute dermal toxicity of the test
material in the Sprague-Dawley CD strain rat. The method was designed to
meet the requirements of the following: OECD Guidelines for the
Testing of Chemicals No. 402 “Acute Dermal Toxicity” (adopted 24
February 1987) Method B3 Acute Toxicity (Dermal) of Commission
A group of ten animals (five males and five females) was given a single,
24-hour, semi-occluded dermal application of the test material to intact
skin at a dose level of 2000 mg/kg bodyweight.
Clinical signs and bodyweight development were monitored during the
study. All animals were subjected to gross necropsy.
Mortality. There were no deaths. Clinical Observations. There were no
signs of systemic toxicity.
Dermal Irritation. There were no signs of dermal irritation.
Bodyweight. All animals showed expected gains in bodyweight over the
study period. Necropsy. No abnormalities were noted at necropsy.
Conclusion. The acute dermal median lethal dose (LD50) and the maximum
sub-lethal dose (LD0) of the test material in the Sprague-Dawley CD
strain rat were found to be greater than 2000 mg/kg bodyweight.
The test item is not classified for acute toxicity according to the CLP
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