Registration Dossier
Registration Dossier
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EC number: 223-804-5 | CAS number: 4079-68-9
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
- Principles of method if other than guideline:
- according to company-internal standard
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- N,N-diethyl-2-propynylamine
- EC Number:
- 223-804-5
- EC Name:
- N,N-diethyl-2-propynylamine
- Cas Number:
- 4079-68-9
- Molecular formula:
- C7H13N
- IUPAC Name:
- diethyl(prop-2-yn-1-yl)amine
Constituent 1
- Specific details on test material used for the study:
- Name of the test substance used in the study report: Golpanol DEP = 1-Diethylaminopropin
Test animals
- Species:
- mouse
- Strain:
- NMRI
- Remarks:
- Ivanovas
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - Mean body weight: males: 27.2 g; females: 24.0 g
- The animals were offered a standardized animal laboratory diet (Altromin R 1324, Altromin GmbH, Lage, Germany)
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on exposure:
- Emulsion in 0.5% aqueous CMC preparation with 2 - 3 drops Cremophor EL.
Test concentrations used: 2.15, 3.16, 4.64, 6.81 and 10% (V/V). - Doses:
- 215, 316, 464, 681 and 1000 µL/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 200 mg/kg bw
- Remarks on result:
- other: original value: ca. 250 µL/kg
- Mortality:
- 215 µL/kg: no deaths after 14 days; 316 µL/kg: 8/10 after 14 days; 464 µL/kg: 7/10 after 14 days; 581 and 1000 µL/kg: 10/10 after 14 days
- Clinical signs:
- Dyspnea, apathy, abdominal and lateral position, staggering, trembling, twitching, partly jumping convulsions, partly clonic-tonic convulsions, poor general state.
- Body weight:
- Normal body weight growth.
- Gross pathology:
- No intra-abdominal substance residues, no adherences.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
