Registration Dossier

Environmental fate & pathways

Hydrolysis

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
hydrolysis
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
key study
Study period:
24 November 2015 to 9 September 2016
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Qualifier:
according to
Guideline:
OECD Guideline 111 (Hydrolysis as a Function of pH)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Radiolabelling:
no
Analytical monitoring:
no
Transformation products:
not measured
Key result
Remarks on result:
not determinable

There were no hydrolysable groups present in any of the stated constituents of the test substance that could be used to calculate a hydrolysis value.

Validity criteria fulfilled:
not specified
Conclusions:
No hydrolysable groups were present, in any of the constituents of the test substance, for estimation of a hydrolysis value.
Executive summary:

The hydrolysis and the Effect of pH of the test material was investigated in a study which was performed under GLP conditions and in accordance with the standardised guideline OECD 111.

Consideration of the chemical structure and physical properties of the test material led to difficulties in determining a reliable half-life for the hydrolysis test. It was not technically feasible to perform the test therefore, it was decided calculate hydrolysis values using the Estimation Program Interface EPI ver. 4.1.

No hydrolysable groups were present, in any of the constituents of the test substance, for estimation of a hydrolysis value.

Description of key information

No hydrolysable groups were present, in any of the constituents of the test substance, for estimation of a hydrolysis value.

Key value for chemical safety assessment

Additional information

The hydrolysis and the Effect of pH of the test material was investigated in a study which was performed under GLP conditions and in accordance with the standardised guideline OECD 111. The study was assigned a reliability score of 1 in accordance with the criteria for assessing data quality set forth by Klimisch et al. (1997).

Consideration of the chemical structure and physical properties of the test material led to difficulties in determining a reliable half-life for the hydrolysis test. It was not technically feasible to perform the test therefore, it was decided calculate hydrolysis values using the Estimation Program Interface EPI ver. 4.1.

No hydrolysable groups were present, in any of the constituents of the test substance, for estimation of a hydrolysis value.