Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 212-634-7 | CAS number: 834-12-8
Toxicity to terrestrial arthropods
Administrative data
Link to relevant study record(s)
Description of key information
The 48-hour contact LD50 for worker honey bees (Apis mellifera) was determined to be greater than 100 µg/bee. The no-observed-effect dosage was 100 µg/bee.
Key value for chemical safety assessment
Additional information
Toxicity to terrestrial arthropods.001 - honeybees - 1988 – key: Acute contact toxicity to worker honey bees (Apis mellifera) was assessed according to the methods defined by the US Environmental Protection Agency Office of Pesticide Programs (EPA OPP) 141-1 (Honey Bee Acute Contact Toxicity) according to GLP. The study exposed 25 bees per dose in duplicate to the test substance by application on the thorax and/or abdomen using a micro-applicator, followed by an observation period of 2 days. Temperature was maintained at 21-23ºC with a relative humidity of 65% and the bees were kept in the dark except during dosing and during daily observations. Observations were made for mortality and signs of toxicity twice on the day of initiation and once on Day 1 and Day 2 after dosing. The 48-hour contact LD50 was determined to be greater than 100 µg/bee. The no-observed-effect dosage was 100 µg/bee.
Toxicity to terrestrial arthropods.002 - honeybees – 1995: Acute contact toxicity to worker honey bees (Apis mellifera) was assessed according to the methods defined by the Instituto Brasileiro do Meio Ambiente e dos Recursos Naturais Renovaveis - IBAMA, under the Toxic Substance Control Act N 139 not according to GLP. The study exposed 20 bees per dose in duplicate to the test substance by application on the thorax using a micro-applicator, followed by an observation period of 1 day. The 24-hour contact LD50 was determined to be greater than 20 µg/bee. The no-observed-effect dosage was 20 µg/bee.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
