Registration Dossier
Registration Dossier
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EC number: 201-155-9 | CAS number: 78-90-0
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 966
- Report date:
- 1966
Materials and methods
- Principles of method if other than guideline:
- other: BASF Test
- GLP compliance:
- no
Test material
- Reference substance name:
- Propylenediamine
- EC Number:
- 201-155-9
- EC Name:
- Propylenediamine
- Cas Number:
- 78-90-0
- Molecular formula:
- C3H10N2
- IUPAC Name:
- propane-1,2-diamine
- Details on test material:
- - Name of test material (as cited in study report): 1,2-Propylendiamin
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Doses:
- 25, 50, 100, 125, 160, 200, 1600 µl/kg bw ( 21.5, 43, 80, 108, 138, 172, 1376 mg/kg bw; conversion into mg/kg is based on the density d= 0.86 g/cm3 - according to BASF internal data)
- No. of animals per sex per dose:
- 10
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: no
- Other examinations performed: clinical signs
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 140 mg/kg bw
- Remarks on result:
- other: conversion into mg/kg is based on the density d= 0.8 g/cm3 - according to BASF internal data
- Mortality:
- 1376 mg/kg bw: 10/10 within 24 h
172 mg/kg bw: 7/10 within 24 h and all 10 animals within 7 days.
138 mg/kg bw: 1/20 within 48 h and 10/20 within 7 days.
108 mg/kg bw: 1/20 within 48 h and 2/20 within 7 days.
80 mg/kg bw. 1/10 within 48 h.
21.5, 43 mg/kg bw: no mortalities. - Clinical signs:
- Staggering, prone and side positions, spring spasms, and belated death.
- Body weight:
- no data
- Gross pathology:
- Local irritations
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
