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EC number: 206-137-4 | CAS number: 303-26-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Bioaccumulation:aquatic/sediments:
Using BCFBAF Program (v3.00) model of EPI suite (2017) the estimated bio concentration factor (BCF) for 1-[(4-chlorophenyl)(phenyl)methyl]piperazine (CAS No. 303-26-4) is 98.88 L/kg wet-wt at 25 deg. c which does not exceed the bioconcentration threshold of 2000. Therefore it is concluded that test chemical 1-[(4-chlorophenyl)(phenyl)methyl]piperazine is non bioaccumulative in food chain.
Additional information
Bioaccumulation:aquatic/sediments:
Various predicted data for the target compound1-[(4-chlorophenyl)(phenyl)methyl]piperazine (CAS No. 303-26-4)and supporting weight of evidence study for its read across chemical were reviewed for the bioaccumulation end point which are summarized as below:
First weight of evidence study was done by using BCFBAF Program (v3.00) model of Estimation Program Interface suite (2017) the estimated bio concentration factor (BCF) for 1-[(4-chlorophenyl)(phenyl)methyl]piperazine (CAS No. 303-26-4) is 98.88 L/kg wet-wt at 25 deg. c which does not exceed the bioconcentration threshold of 2000.
Next predicted data study was done by using Bio-concentration Factor (v12.1.0.50374) module of(ACD (Advanced Chemistry Development)/I-Lab predictive module, 2017) module in this study theBio-concentration Factor at pH 7 of the chemical 1-[(4-chlorophenyl)(phenyl)methyl]piperazine (CAS no.303 -26 -4) estimated to be 2.88 dimensionless.
Another predicted data study was done by using Scifinder database of(American Chemical Society (ACS), 2017) in this studythe Bioconcentration factor (BCF) of test substance 1-[(4-chlorophenyl)(phenyl)methyl]piperazine at pH 1 -7 range and temperature 25 °C was estimated to be 1 dimensionless and at pH 8, 9 and 10 BCF values was estimate to be 7.18, 49.7 and 125 dimensionless respectively.
Next weight of evidence study was done by Using Chemspider-ACD/Phychem suite prediction model of Royal Society of Chemistry (2017) in this studythe Bioconcentration factor (BCF) for test chemical1-[(4-chlorophenyl)(phenyl)methyl]piperazine (CAS No: 303-26-4) was predicted in aquatic organisms by at pH 5.5 and pH 7.4.The Bioconcentration factor (BCF) of test substance1-[(4-chlorophenyl)(phenyl)methyl]piperazine at pH 5.5 was estimated to be 1 dimensionless and pH 7.4 was estimated to be 15.06 dimensionless.
Another weight of evidence study was done from CompTox Chemistry Dashboard using OPERA (OPEn (quantitative) structure-activity Relationship Application) V1.02 model in which calculation based on PaDEL descriptors (calculate molecular descriptors and fingerprints of chemical) the bioaccumulation i.e BCF for test substance 1-[(4-chlorophenyl)(phenyl)methyl]piperazine (CAS no.303 -26 -4) was estimated to be 60.8 dimensionless. The predicted BCF result was based on the 5 OECD principles.
In a supporting weight of evidence study the Bioaccumulation study was conducted on test organism Cyprinus carpio for 6 weeks for evaluating the bioconcentration factor (BCF value) of red across Piperazine (CAS no.110-85-0) from authoritative database (J check, 2017).The study was performed according to other guideline "Bioaccumulation test of a chemical substance in fish or shellfish" provided in "the Notice on the Test Method Concerning New Chemical Substances", respectively. Cyprinus carpio was used as a test organism for the study. Read across chemical nominal conc. used for the study were 1mg/l and 0.1 mg/l, respectively. Range finding study involve the TLm (48 hr) ≥ 1000 mg/l (w/v) on Rice fish (Oryzias latipes).The bioconcentration factor (BCF value) of substance Piperazine on Cyprinus carpio was determined to be ≤ 0.3 – 0.9 L/Kg at a conc. of 1 mg/l and ≤ 3.9 L/Kg at a conc. of 0.1 mg/l, respectively, which does not exceed the bioconcentration threshold of 2000, indicating that the red across chemical Piperazine is not expected to bioaccumulate in the food chain.
Last weight of evidence study was also supporting study done from authoritative database (HSDB, 2017) in this study the BCF value of read across chemical 2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazin-1-yl]ethoxy]acetic acid (CAS no. 83881-51-0) estimated was 3 dimensionless by using log Kow of 1.70 and regression derived equation and it is far less than 2000 criteria so it is concluded that test chemical 2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazin-1-yl]ethoxy]acetic acid is non bioaccumulative.
On the basis of above results for target chemical 1-[(4-chlorophenyl)(phenyl)methyl]piperazine (CAS No. 303-26-4) (from EPI suite, ACD labs, Sci Finder database, Chemspider and CompTox Chemistry Dashboard 2017) and for its read across chemicals (From HSDB and J check) it can be concluded that the BCF value of test substance 1-[(4-chlorophenyl)(phenyl)methyl]piperazine ranges from 1-125 dimensionless which does not exceed the bioconcentration threshold of 2000, indicating that the chemical 1-[(4-chlorophenyl)(phenyl)methyl]piperazine is expected to be non-bioaccumulative in the food chain
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