Registration Dossier
Registration Dossier
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EC number: 250-342-1 | CAS number: 30798-32-4
Endpoint summary
Administrative data
Description of key information
The LD50 for acute oral toxicity of the substance was determined to exceed 5000 mg/kg bw in a GLP-compliant OECD 423 study.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 5 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Acute toxicity: oral
Acute oral toxicity of the test substance in rat (Acute Toxic Class Method) was evaluated in a GLP compliant study which was carried out in compliance with OECD 423, EU B.1 tris, OPPTS 870.1100 and the JMAFF Guidelines. The test substance was administered by oral gavage to two consecutive groups of three female Wistar rats at 2000 mg/kg body weight. Animals were subjected to daily observations and weekly determination of body weight. Macroscopic examination was performed after terminal sacrifice (Day 15). No mortality occurred. Hunched posture and/or piloerection were noted for five out of six animals on Day 1 only. The mean body weight gain shown by the animals over the study period was considered to be similar to that expected for normal untreated animals of the same age and strain. No abnormalities were found at macroscopic post mortem examination of the animals. The oral LD50 value of the test substance in Wistar rats was established to exceed 2000 mg/kg body weight. According to the OECD 423 test guideline, the LD50 cut-off value was considered to exceed 5000 mg/kg body weight.
Justification for classification or non-classification
Based on the available information classification for acute oral toxicity is not warranted in accordance with EU Classification, Labeling and Packaging of Substances and Mixtures (CLP) Regulation No. 1272/2008.
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