Registration Dossier
Registration Dossier
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EC number: 240-968-3 | CAS number: 16919-19-0
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Publication date - 07 September 1984.
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- study with volunteers
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
Test material
- Reference substance name:
- disodium;hexafluorosilicon(2-)
- Cas Number:
- 16893-85-9
- Molecular formula:
- Na2SiF6
- IUPAC Name:
- disodium;hexafluorosilicon(2-)
Constituent 1
- Specific details on test material used for the study:
- Test material: Sodium hexafluorosilicate
Method
- Type of population:
- not specified
- Route of administration:
- dermal
- Details on study design:
- The substance (2% aq.) and water were used, applied 3 times a day on the forearm. The observations were carried out after 48 and 96 hours the applications.
Results and discussion
- Results of examinations:
- The test was negative after 48 as well as 96 hours. At the 48 hour observation, slight itching and barely visible papules were seen with subjects treated with water.
Applicant's summary and conclusion
- Conclusions:
- Sodium hexafluorosilicate substance (2% aq.) was found to be negative in the scratch testing at 48 and 96 hours.
- Executive summary:
Scratch testing with the sodium hexafluorosilicate substance (2% aq.) and water was carried out, in which the applications were done 3 times a day on the forearm. The observations were carried out after 48 and 96 hours the applications. The test was negative after 48 as well as 96 hours with sodium hexafluorosilicate. At the 48 hour observation, slight itching and barely visible papules were seen with subjects treated with water.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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