Registration Dossier
Registration Dossier
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EC number: 944-817-9 | CAS number: 244626-73-1
Endpoint summary
Administrative data
Description of key information
To assess the short-term toxicity of the registered substance to aquatic organisms, experimental studies of reliability 1 (Klimisch rating), based on international guidelines, are available on the three aquatic trophic levels (algae, aquatic invertebrate and fish). Among all acute data available, the fish Danio rerio is the most sensitive species with a 96h-LC50 at 1.1 mg/L based on mean measured concentrations. For the aquatic invertebrate Daphnia magna, the 48h-EC50 was determined to be 1.6 mg/L based on mean measured concentrations, and for the algae Pseudokirchneriella subcapitata, the 72h-ErC50 and ErC10 (based on growth rate) were determined to be 5.71 mg/L and 1.38 mg/L, respectively, based on initial measured concentrations.
In addition, to assess the toxicity of the registered substance to microorganisms, one experimental study of relability 2 (Klimisch rating), based on international guideline, is available on Pseudomonas putida. None of the concentrations tested between 0.05 and 10 mgL resulted in an inhibition of bacterial growth of P. putida after 16 hours of exposure. Therefore, the 16h-NOEC is equivalent to 10 mg/L. However, considering the toxicity effect observed in the biodegradation studies mentioned in the present dossier, the toxic effect observed in activated sludge micro-organisms up to 84 days at the tested concentration of 2 mg/L (AkzoNobel (2012) OECD 301D study) is considered relevant for chemical safety assessment. Therefore, the estimated NOEC for the toxicity to STP micro-organisms can be expected at 1.0 mg/L (by dividing the toxic concentration by 2).
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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