(1R,2S,5R)-2-isopropyl-N-(4-methoxyphenyl)-5-methylcyclohexanecarboxamide

Ecotoxicological Summary

Conclusion on classification

Aquatic toxicity

Acute toxicity data of the substance are available for two trophic levels (daphnia and algae) and based on a saturated solution of the test item.

The results indicate that the substance does not immobilise Daphnia magna up to a concentration of 0.37 mg/L (geometric mean measured). The 48-h EC50 value was estimated with > 0.37 mg/l whereas the 48-h NOEC amounts to ≥ 0.37 mg/L.

Further, the substance did not inhibit the growth of the freshwater green alga Pseudokirchneriella subcapitata up to a mean measured concentration of 0.32 mg/L. Thus, ErC10- and ErC50-values for the inhibition of growth rate after 72-hours were > 0.32 mg/L, respectively. The NOEC for the inhibition of growth rate after 72-hours amounts to ≥ 0.32 mg/L

Thus, acute toxicity is not observed at levels up to the water solubility.

The 72 -h ErC10 of > 0.32 mg/L for the effect of the test item on growth rate of the freshwater green alga Pseudokirchneriella subcapitata was selected as chronic effect value for classification.

Acute (short-term) aquatic hazard:

48-h EC50 > 0.37 mg/L (daphnia; geom. mean meas. concentration)

72-h ErC50 > 0.32 mg/L (algae; mean meas. concentration)

 

Since acute toxicity is not observed at levels up to the water solubility, classification as ACUTE/SHORT-TERM AQUATIC HAZARD is not required.

Chronic (long-term) aquatic hazard based on chronic, acute data and environmental fate of the product:

72-h ErC10 > 0.32 mg/L (algae - chronic data)

48-h EC50 > 0.37 mg/L (daphnia – acute data)

Not readily biodegradable

log Kow 3.95

 

The substance is not rapidly degradable but the log Kow is below 4. Further, the EC50 for immobilisation of daphnia as well as the EC10 for growth rate inhibition of algae are above the water solubility. Thus, classification as CHRONIC/LONG-TERM AQUATIC HAZARD is not required.