Registration Dossier
Registration Dossier
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EC number: 210-088-4 | CAS number: 605-50-5
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 27 May - 02 September 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Conducted according to OECD guidelines and GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- column elution method
Test material
- Reference substance name:
- Diisoamyl phthalate
- IUPAC Name:
- Diisoamyl phthalate
- Details on test material:
- - Name of test material (as cited in study report): Diisoamyl phthalate
- Substance type: organic
- Physical state: liquid
- Analytical purity: 100%
- Lot/batch No.: 7920-1-1
- Expiration date of the lot/batch:12 August 2012
- Storage condition of test material: room temperature in the dark
Constituent 1
Results and discussion
Water solubility
- Water solubility:
- 1.1 mg/L
- Temp.:
- 20 °C
- pH:
- >= 6.6 - <= 7.1
- Details on results:
- The detector calibration was found to be linear over the range 0 to 0.8 mg/l of standard solutions in acetonitrile:water (1:1 v/v) with a regression coefficient of 0.9999.
A mean recovery of approximately 80% of Diisoamyl phthalate from fortified control samples prepared at the determined solubility level was achieved and deemed to be acceptable, whilst no significant interfering peaks were evident in blank control solutions.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results: slightly soluble (0.1-100 mg/L)
Diisoamyl phthalate was found to have a water solubility of 1.1 mg/l at 20°C.
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