Registration Dossier
Registration Dossier
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EC number: 231-146-5 | CAS number: 7440-36-0
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Documentation of the study is insufficient for assessment. Tthe amount of antimony trioxide is not known and no control animals was used.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 950
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- No guideline specified at the time of conduct.
In this briefly reported study the toxicity of a polythene composition containing antimony trioxide (polythene + 0.2% “Akroflex” C/ antimony trioxide/“Chlorowax”) was tested.
(2) doses which varied between 600 - 1000 mg/kg/day were fed to 6 guinea pigs for 5d/wk for a total of 10 treatments. - GLP compliance:
- not specified
Test material
- Reference substance name:
- Flame Resistant Polythene Composition
- IUPAC Name:
- Flame Resistant Polythene Composition
- Details on test material:
- - Name of test material (as cited in study report): Polythene composition JRP-10083-B (polythene + 0.2%"Akroflex" C / antimony trioxide /
"Chlorowax" 70 57/20/15)
- Substance type: formulation
- Composition of test material, percentage of components: polythene + 0.2% “Akroflex” C/ antimony trioxide/ “Chlorowax”
- no other details on test material stated
Constituent 1
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: feed
- Details on oral exposure:
- - not stated
- Doses:
- varied between 600 - 1000 mg/kg/day for 5 days/wk and total of 10 treatments
- No. of animals per sex per dose:
- 6 guinea pigs
- Control animals:
- no
Results and discussion
Effect levels
- Remarks on result:
- other: Study documentation is insufficient for assessment e.g. number of animals not stated.
- Mortality:
- no mortality
- Gross pathology:
- gross and micropathological examination did not show any organic damage attributable to the substrate
Applicant's summary and conclusion
- Conclusions:
- This study is regarded as invalid and will not be used for the risk assessment of diantimony trioxide, due to the fact that the extract was not analysed and the amount of diantimony trioxide not known, the number of animals included in the study was not stated and no control animals was used.
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