Registration Dossier
Registration Dossier
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EC number: 201-202-3 | CAS number: 79-39-0
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: only short documentation
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 966
- Report date:
- 1966
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Method: no data
- GLP compliance:
- no
Test material
- Reference substance name:
- Methacrylamide
- EC Number:
- 201-202-3
- EC Name:
- Methacrylamide
- Cas Number:
- 79-39-0
- Molecular formula:
- C4H7NO
- IUPAC Name:
- methacrylamide
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Duration of exposure:
- 4 hrs
- Doses:
- 20% or 10% solutions
- No. of animals per sex per dose:
- 10
- Control animals:
- yes
- Details on study design:
- In this study, 20% or 10% solution of methacrylamide was applied for 4 hours to abdominal skin.
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD0
- Remarks:
- 4 hours application
- Effect level:
- > 1 600 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Executive summary:
In an acute dermal toxicity study 10 rats per dose group were dermally exposed to 20- and 10-% solutions of Methacrylamide in 60% ethanol, (96 %, denatured with 2 % Benzene) 20 % Propanol and 20 % water for 4 hours to 10 % of body surface area. No mortality occured. Only temporary apathie just like the control group with the vehicle was observed.
Dermal LD0 > 1600 mg/kg
Methacrylamide is of low toxicity
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