Registration Dossier

Administrative data

Description of key information

The key skin sensitisation test was performed with 2,4,6,8,10-pentamethylcyclopentasiloxane,

using a modified Buehler method (Ritz and Buehler, 1980). The study was conducted according to OECD Guidelines for Testing of Chemicals, Number 406 "Skin Sensitization” and concluded the test material to be not sensitising to skin.

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

A skin sensitisation test was performed with 2,4,6,8,10 -pentamethylcyclopentasiloxane,

using a modified Buehler method (Ritz and Buehler, 1980) The study was conducted according to OECD Guidelines for Testing of Chemicals, Number 406 "Skin Sensitization”.

After a three-week induction period with the pure substance, there was no skin reaction in the control and test group after the challenge procedure performed with a 15% solution of the test substance in acetone. The acetone, itself, did not show any local skin reactions and was, therefore, considered to be suitable for this type of study.


Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available

Justification for classification or non-classification

Based on the available data, 2,4,6,8,10- pentamethycyclopentasiloxane does not require classification for skin sensitisation according to Regulation (EC) No 1272/2008.