Registration Dossier
Registration Dossier
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EC number: 400-600-6 | CAS number: 71868-10-5 ACETOCURE 97; GENOCURE*PMP; IGM 4817; IRGACURE 907; SPEEDCURE 97
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 1 988
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 401
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-methyl-1-(4-methylthiophenyl)-2-morpholinopropan-1-one
- EC Number:
- 400-600-6
- EC Name:
- 2-methyl-1-(4-methylthiophenyl)-2-morpholinopropan-1-one
- Cas Number:
- 71868-10-5
- Molecular formula:
- C15H21NO2S
- IUPAC Name:
- 2-methyl-1-[4-(methylsulfanyl)phenyl]-2-(morpholin-4-yl)propan-1-one
Constituent 1
Test animals
- Species:
- other: rat / Til: RAI f (SPF)
Administration / exposure
- Vehicle:
- other: 0.5% CMC and 0.1% polysorbate 80
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 984 mg/kg bw
- Mortality:
- Male: 1000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 1
Male: 4000 mg/kg bw; Number of animals: 5; Number of deaths: 4
Female: 5 mg/kg bw; Number of animals: ; Number of deaths: 2
Female: 5 mg/kg bw; Number of animals: ; Number of deaths: 3
Female: 5 mg/kg bw; Number of animals: ; Number of deaths: 5 - Clinical signs:
- other: Signs of toxicity related to dose levels: Unspecific symptoms of toxicity, reversible after 19 days in the surviving animals of the 2000 mg/kg group and after 13 days in the animals of the 1000 mg/kg group.
- Gross pathology:
- Effects on organs:
2 animals of the 4000 mg/kg group showed spotted lungs. 1 animal of the 1000 mg/kg group exhibited bilateral eye opacity, which was not reversible during the observation period. various animals showed skin erythema and alopezia.
After 3 weeks hair started to grow again in the effected area.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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