Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

The following information is taken into account for any hazard / risk assessment:

HFO-1234ze was not a skin sensitizer when evaluated in human subjects in a repeated insult patch test. However, no signs of skin or respiratory sensitization were observed in experimental animals exposed by inhalation to up to 15,000 ppm HFO-1234ze in the atmosphere for up to 13 consecutive weeks. 

Migrated from Short description of key information:
HFO-1234ze was not a skin sentizer in human subjects evaluated in a repeated insult patch test.

Justification for classification or non-classification

HFO-1234ze was not a skin sensitizer in humans when evaluated in a repeated insult patch test. Classification is not necessary.