Registration Dossier

Administrative data

Description of key information

HFO-1234ze did not cause skin irritation in rabbit skin following 60 sec, 3 minutes, or 4 hours of exposure.  No dedicated studies are available for the evaluation of the eye irritating potential of HFO-1234ze. However, acute exposure up to 270,000 ppm and repeated inhalation exposure up to 15,000 ppm HFO-123ze did not show signs of eye, skin or respiratory irritation.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Additional information

Justification for classification or non-classification

No skin irritation was observed in rabbit skin following 60 sec, 3 minute or 4 hour dermal exposure to HFO-1234ze.