Registration Dossier

Administrative data

Endpoint:
additional toxicological information
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Study conducted under GLP conditions using methodology that is well accepted by organization responsible for flourochemicals

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2006
Report Date:
2006

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Cardiac sensitization was considered to have occurred if the response to epinephrine was enhanced following administration of the test article.

GLP compliance:
yes
Remarks:
US laboratory, no certificate available

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Any other information on results incl. tables

All animals survived to study termination. There were no test article-related clinical observations. Body weights were unaffected by test article administration.No cardiac sensitization observed in any animals

Applicant's summary and conclusion

Conclusions:
Cardiac sensitization was to epinephrine was not observed in dogs exposed by inhalation to HFO-1234ze up to to a level of 120,000 ppm (highest dose tested)