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EC number: 236-675-5
CAS number: 13463-67-7
literature and substance evaluation:
A large number of studies identified during the literature search
applied so-called titanium dioxide as test item without any or with
limited documentation on the identity of the tested substance. It is
problematic to base the hazard and risk assessment of clearly
characterised titanium dioxide on information generated with poorly
characterised test items that are without any market relevance.
Consequently, all studies conducted with self-synthesised titanium
dioxide nanomaterials were rated not relevant for hazard and risk
assessment purposes (in accordance with ECHA Guidance Chapter R.4:
Evaluation of available information, Version 1.1, December 2011).
Furthermore, all references obtained during the literature search were
evaluated according to the criteria laid down in ECHA Guidance R.4
(Version 1.1, December 2011), the OECD Guidance Document 34 (2005) and
the reference by Klimisch et al. (1997). The screening foresees an
incremental procedure evaluating the relevance, reliability and adequacy
(for further information refer to the attached statement on the
literature evaluation criteria in IUCLID section 13).
Acute and chronic aquatic toxicity data for micro- and nanosized
TiO2 are available for three trophic levels.
Toxicity endpoints do not meet the classification criteria of
short-term aquatic hazard Category 1 and Long-term aquatic hazard
Category 1, 2 and 3. Thus, classification as hazardous to the aquatic
environment is not required according to Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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