Methacrylic acid

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Remarks:

As the substance was administered undiluted, it can be expected that the corrosive effects were manifested in the GI tract and the LD50 cannot be attributed solely to systemic toxicity. Very limited documentation of experimental details.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1977

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Principles of method if other than guideline:

Standard acute method: strain: Wistar; 8-10 male animals per group, 900-1750 mg/kg undiluted.

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Methacrylic acid

EC Number:

201-204-4

EC Name:

Methacrylic acid

Cas Number:

79-41-4

Molecular formula:

C4H6O2

IUPAC Name:

methacrylic acid

Test material form:

liquid

Specific details on test material used for the study:

Methacrylic acid (CAS: 79-41-4)
Purity: 99 % administered undiluted
Supplier: Merck

Test animals

Species:

rat

Strain:

Wistar

Sex:

male

Details on test animals or test system and environmental conditions:

weight: 200 - 300 g

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Doses:

0.9, 1.00, 1.25, 1.50, 1.75 g/kg

No. of animals per sex per dose:

10 males per group at 0.9, 1.00, 1.25 g/kg; 8 males per group at 1.50, 1.75 g/kg

Details on study design:

Animals were observed for 10 days following adminstration of the substance.

Results and discussion

Effect levels

Key result

Sex:

male

Dose descriptor:

LD50

Effect level:

1 320 mg/kg bw

Based on:

test mat.

Mortality:

Dose g/kg Mortality
0.9 0/10
1.00 2/10
1.25 4/10
1.50 6/8
1.75 8/8

Applicant's summary and conclusion

Interpretation of results:

Category 4 based on GHS criteria

Conclusions:

Using a valid scientific method, the oral LD50 of undiluted MAA to male rats was 1320 mg/kg bw.

Executive summary:

Using a valid scientific method, the oral LD50 of undiluted MAA to male rats was 1320 mg/kg bw. Thetest was performed with five test concentrations of 0.9, 1.00, 1.25, 1.50, 1.75 g/kg bw and 8 to 10 animals per dose group.