Registration Dossier
Registration Dossier
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EC number: 231-113-5 | CAS number: 7440-03-1
Toxicity to terrestrial plants
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to terrestrial plants: long-term
- Type of information:
- experimental study planned
- Study period:
- The test will be conducted after a decision on the requirement to carry out the proposed test has been taken according to the procedure laid down in Regulation (EC) 1907/2006 and a deadline to submit the information required has been set by the Agency.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 208 (Terrestrial Plants, Growth Test)
Reference
Description of key information
A terrestrial long-term test according to OECD Guideline 208 (Terrestrial Plant Test: Seedling Emergence and Seedling Growth Test) will be conducted after a decision on the requirement to carry out the proposed test has been taken according to the procedure laid down in Regulation (EC) 1907/2006 and a deadline to submit the information required has been set by the Agency.
Key value for chemical safety assessment
Additional information
No soil toxicity long-term test is available for niobium (CAS 7440-03-1).
Aquatic long-term tests with algae and aquatic invertebrates, as well as an acute toxicity test with aquatic microorganisms are available for niobium. Following effect values were determined: Aquatic algae revealed an EC10 (72 h) of 16.1 mg/L (nominal, OECD 201) for Raphidocelis subcapitata, aquatic invertebrates showed a NOEC (21 d) of ≥ 10 mg/L (nominal, OECD 211) for Daphnia magna, and aquatic microorganisms showed a NOEC (3 h) of ≥ 1000 mg/L (nominal, OECD 209) for activated sludge microorganisms. The observed effects on algae are considered to be caused by physical effects due to the presence of particles in the test medium and not by the intrinsic toxicity of the test item. Thus, the available acute and chronic ecotoxicity data show that, niobium (CAS 7440-03-1) is not acutely and chronically toxic to freshwater organisms.
This assumption will be reevaluated, based on the results of the ongoing long-term tests with fish (OECD 210; CCH-D-2114517391-56-01/F). Reasons for the delay are summarized in the statements attached in IUCLID section 6.1.2 (‘Status of Fish early life stage toxicity Tests (OECD 210) with Niobium metal powder’ (Sept. 2022) and Status of Aquatic Toxicity Tests (OECD 201, 210 and 211) with Niobium metal powder (May 2022).
Considering the available aquatic toxicity results, it is not expected that niobium (CAS 7440-03-1) shows long-term effects to soil organisms.
For assessing this assumption, a soil toxicity long-term test will be conducted. Since aquatic algae were the most sensitive organisms group upon the tested aquatic organisms, a terrestrial long-term test according to OECD Guideline 208 (Terrestrial Plant Test: Seedling Emergence and Seedling Growth Test) will be conducted. This test will be performed after a decision on the requirement to carry out the proposed test has been taken according to the procedure laid down in Regulation (EC) 1907/2006 and a deadline to submit the information required has been set by the Agency.
The choice of the terrestrial tests will be reevaluated, based on the results of the ongoing long-term tests with fish (OECD 210).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
